Yokohama-shi, Japan
Yokohama-shi, Japan

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Patent
Meiji Seika Pharma Co. | Date: 2015-03-04

A method for producing a compound represented by formula (I) comprises the steps of:


Patent
Meiji Seika Pharma Co. | Date: 2017-01-18

A method for producing a compound represented by formula (I) comprises the steps of:acylating an amino group at position 2 of a compound represented by formula (A) by use of trifluoroacetic acid as an acylating agent to thereby produce a compound represented by formula (B); andfurther alkylating a nitrogen atom at position 1 of the compound represented by formula (B), as follows


Patent
Mitsui Chemicals Inc. and Meiji Seika Pharma Co. | Date: 2017-01-03

What is aimed at is provision of an inexpensive and efficient saccharification method for lignocellulose using a thermostable xylanase and provision of a mutant xylanase that has a substitute amino acid residue, and that exhibits stable activity even under severe conditions in which enzymes easily inactivate, and that provides an initial rate of reaction not significantly reduced as compared to a wild-type xylanase corresponding to the mutant xylanase. Provided is a method of producing a saccharified product of lignocellulose, including contacting a lignocellulosic raw material with a thermostable xylanase, and a mutant xylanase that provides an initial rate of reaction that is at least 70% of that provided by a wild-type xylanase corresponding thereto, that has a xylanase activity after heat treatment at 50 C. for 24 hours that is at least 50% of its xylanase activity before the heat treatment, and that has a substitute amino acid residue.


Patent
Meiji Seika Pharma Co. | Date: 2016-05-18

Provided is a compound represented by formula (1a) or a pharmacologically acceptable salt thereof However, R^(1) to R^(6) in the formula each independently represent an alkyl group or the like.


Patent
Meiji Seika Pharma Co. | Date: 2016-03-25

A compound of formula (Ie): wherein Ar, R_(1), R_(4c )and Y are as defined herein and a method of controlling pests using the compound.


The present invention provides a process for producing a diazabicyclooctane derivative represented by Formula (IV) and intermediates thereof:^(1) is 2,5-dioxopyrrolidin-1-yl, 1,3-dioxo-3a,4,7,7a-tetrahydro-1H-isoindol-2(3H)-yl, 1,3-dioxohexahydro-1H-isoindol-2(3H)-yl, or 3,5-dioxo-4-azatricyclo[5.2.1.0^(2.6)]dec-8-en-4-yl; R^(2) is hydrogen, ClCO- or Cl_(3)COCO-; R^(3) is C_(1-6) alkyl or heterocyclyl, or forms a 3- to 7-membered heterocyclic ring together with the -O-NH- to which it is attached; and OBn is benzyloxy).


The present invention provides crystalline forms of a diazabicyclooctane derivative represented by the following Formula (VII), particularly Formula (VII-1), and processes for producing the same.


Patent
Meiji Seika Pharma Co. | Date: 2016-02-17

Specific amine derivatives have been found to possess excellent activities as pest control agents.


Patent
Meiji Seika Pharma Co. | Date: 2016-04-13

It has been found that adding carbon dioxide or the like to a solution containing arbekacin free base makes it possible to produce arbekacin derivatives including arbekacin carbonate and carbamic acid of arbekacin. Moreover, it has been found that the arbekacin derivatives have a high stability, and that the use thereof enables efficient productions of highly-pure arbekacin free base and pharmaceutically acceptable salt thereof.


An optically active (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid compound defined by the following formula (F): wherein R^(1 )represents CO_(2)R, CO_(2)M, or CONH_(2), wherein R represents an allyl group or a benzyl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R^(2 )represents a benzyl group or an allyl group.

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