Yokohama-shi, Japan
Yokohama-shi, Japan

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Patent
Meiji Seika Pharma Co. | Date: 2015-03-04

A method for producing a compound represented by formula (I) comprises the steps of:


Patent
Meiji Seika Pharma Co. | Date: 2017-01-18

A method for producing a compound represented by formula (I) comprises the steps of:acylating an amino group at position 2 of a compound represented by formula (A) by use of trifluoroacetic acid as an acylating agent to thereby produce a compound represented by formula (B); andfurther alkylating a nitrogen atom at position 1 of the compound represented by formula (B), as follows


Patent
Meiji Seika Pharma Co. | Date: 2016-05-18

Provided is a compound represented by formula (1a) or a pharmacologically acceptable salt thereof However, R^(1) to R^(6) in the formula each independently represent an alkyl group or the like.


Patent
Meiji Seika Pharma Co. | Date: 2016-03-25

A compound of formula (Ie): wherein Ar, R_(1), R_(4c )and Y are as defined herein and a method of controlling pests using the compound.


The present invention provides a process for producing a diazabicyclooctane derivative represented by Formula (IV) and intermediates thereof:^(1) is 2,5-dioxopyrrolidin-1-yl, 1,3-dioxo-3a,4,7,7a-tetrahydro-1H-isoindol-2(3H)-yl, 1,3-dioxohexahydro-1H-isoindol-2(3H)-yl, or 3,5-dioxo-4-azatricyclo[5.2.1.0^(2.6)]dec-8-en-4-yl; R^(2) is hydrogen, ClCO- or Cl_(3)COCO-; R^(3) is C_(1-6) alkyl or heterocyclyl, or forms a 3- to 7-membered heterocyclic ring together with the -O-NH- to which it is attached; and OBn is benzyloxy).


The present invention provides crystalline forms of a diazabicyclooctane derivative represented by the following Formula (VII), particularly Formula (VII-1), and processes for producing the same.


Patent
Meiji Seika Pharma Co. | Date: 2016-02-17

Specific amine derivatives have been found to possess excellent activities as pest control agents.


Patent
Meiji Seika Pharma Co. | Date: 2016-04-29

To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): [where Ar represents a phenyl group or a 5- to 6-membered heterocycle, R_(1 )represents a C_(1-6 )alkyl group, and Y represents a hydrogen atom; a halogen atom; a hydroxyl group; a C_(1-6 )alkyl group which may be substituted with a halogen atom; a C_(1-6 )alkyloxy group which may be substituted with a halogen atom; a cyano group; a formyl group; or a nitro group].


Patent
Meiji Seika Pharma Co. | Date: 2016-04-13

It has been found that adding carbon dioxide or the like to a solution containing arbekacin free base makes it possible to produce arbekacin derivatives including arbekacin carbonate and carbamic acid of arbekacin. Moreover, it has been found that the arbekacin derivatives have a high stability, and that the use thereof enables efficient productions of highly-pure arbekacin free base and pharmaceutically acceptable salt thereof.


An optically active (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid compound defined by the following formula (F): wherein R^(1 )represents CO_(2)R, CO_(2)M, or CONH_(2), wherein R represents an allyl group or a benzyl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R^(2 )represents a benzyl group or an allyl group.

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