Mei Ho Institute of Technology

Pingtung, Taiwan

Mei Ho Institute of Technology

Pingtung, Taiwan
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Niu S.F.,Taipei Medical University | Chung M.-H.,Taipei Medical University | Chen C.-H.,Mei Ho Institute of Technology | Hegney D.,National University of Singapore | And 2 more authors.
Journal of Nursing Research | Year: 2011

Background: Disrupted circadian rhythm, especially working night duty together with irregular sleep patterns, sleep deprivation, and fatigue, creates an occupational health risk associated with diminished vigilance and work performance. Purpose: This study reviewed the effect of shift rotations on employee cortisol profile, sleep quality, fatigue, and attention level. Methods: Researchers conducted a systematic review of relevant articles published between 1996 and 2008 that were listed on the following databases: SCOPUS, OVID, Blackwell Science, EBSCO Host, PsycINFO, Cochrane Controlled Trials Register, and CEPS. A total of 28 articles were included in the review. Results: Previous research into the effects of shift work on cortisol profiles, sleep quality, fatigue, and attention used data assessed at evidence Levels II to IV. Our systematic review confirmed a conflict between sleepYwake cycle and lightYdark cycle in night work. Consequences of circadian rhythm disturbance include disruption of sleep, decreased vigilance, general feeling of malaise, and decreased mental efficiency. Shift workers who sleep during the day (day sleepers) experience cortisol secretion increases, which diminish the healing power of sleep and enjoy 1 to 4 hours less sleep on average than night sleepers. Sleep debt accumulation results in chronic fatigue. Prolonged fatigue and inadequate recovery result in decreased work performance and more incidents. Rotation from day shift to night shift and its effect on shiftworkers was a special focus of the articles retained for review. Conclusions: Disturbed circadian rhythm in humans has been associated with a variety of mental and physical disorders andmay negatively impact on work safety, performance, and productivity. Copyright © 2011 Taiwan Nurses Association.


Lin Y.,Taipei Medical University | Chu H.,Institute of Aerospace Medicine | Chu H.,Tri Service General Hospital | Yang C.-Y.,Taipei Medical University | And 7 more authors.
International Journal of Geriatric Psychiatry | Year: 2011

Objectives This study explored the effectiveness of group music intervention against agitated behavior in elderly persons with dementia. Methods This was an experimental study using repeated measurements. Subjects were elderly persons who suffered from dementia and resided in nursing facilities. In total, 104 participants were recruited by permuted block randomization and of the 100 subjects who completed this study, 49 were in the experimental group and 51 were in the control group. The experimental group received a total of twelve 30-min group music intervention sessions, conducted twice a week for six consecutive weeks, while the control group participated in normal daily activities. In order to measure the effectiveness of the therapeutic sessions, assessments were conducted before the intervention, at the 6th and 12th group sessions, and at 1 month after cessation of the intervention. Longitudinal effects were analyzed by means of generalized estimating equations (GEEs). Results After the group music therapy intervention, the experimental group showed better performance at the 6th and 12th sessions, and at 1 month after cessation of the intervention based on reductions in agitated behavior in general, physically non-aggressive behavior, verbally non-aggressive behavior, and physically aggressive behavior, while a reduction in verbally aggressive behavior was shown only at the 6th session. Conclusions Group music intervention alleviated agitated behavior in elderly persons with dementia. We suggest that nursing facilities for demented elderly persons incorporate group music intervention in routine activities in order to enhance emotional relaxation, create inter-personal interactions, and reduce future agitated behaviors. Copyright © 2010 John Wiley & Sons, Ltd.


Tsai C.-W.,National Central University | Liu C.-I.,Mei Ho Institute of Technology | Chan Y.-C.,National Central University | Tsai H.-H.G.,Mei Ho Institute of Technology | And 2 more authors.
Journal of Physical Chemistry B | Year: 2010

Chromatographic behavior of a small peptide in RP-HPLC can generally be correlated with the summation of the hydrophobic contribution from its composed amino acid residues. But this approach fails to predict the retention deviation between two sequence shuffled peptides. One set of 11-residue peptides was designed to study the conformation effect. The two sequence shuffled peptides had different conformations and showed different retention behaviors in a C18 column. The retention factors of the relatively helical peptide GELELKLKLEG (GELE) were consistently lower than those of the peptide GELKLELKLEG (GELK) at all conditions under investigation. All atom molecular dynamics (MD) simulation was performed to study the origin of the deviation in column retention. Circular dichroism spectra and MD simulation confirmed that the structure of GELE is more helical and the energy of GELE in solution is lower than that of GELK. The deformation energies calculated from MD described well the concentration effect on δCP obtained from column retention data. After analyzing the desolvation, deformation, and interaction energies after the adsorption of these two sequence shuffled peptides on C18 self assembly monolayer (SAM), it was found that the longer retention of GELK in the column was not due to its higher accessibility toward the hydrophobic stationary phase. The structurally rigid peptide, i.e., the low potential energy one, owned a lower retention time because its ability to minimize the overall adsorption energy was limited. This result suggested that the overall potential energy of peptide in solution calculated from MD simulation may be used to quantify the conformation effect. © 2010 American Chemical Society.


Wang G.-H.,Chia Nan University of Pharmacy and Science | Huang H.-C.,Cheng Shiu University | Su J.-H.,Mei Ho Institute of Technology | Wu Y.-C.,Kaohsiung Medical University | Sheu J.-H.,National Sun Yat - sen University
Chemical and Pharmaceutical Bulletin | Year: 2010

Six new sesquiterpenoids, paralemnolins J-O (1-6), along with one novel norsesquiterpenoid, paralemnolin P (7), have been isolated from the soft coral Paralemnalia thyrsoides. The structures of metabolites 1-7 were established on the basis of extensive NMR study and chemical methods. The structure of 5 was further confirmed by a single-crystal X-ray analysis. Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is described. © 2010 Pharmaceutical Society of Japan.


Chiang K.-J.,Tri Service General Hospital | Chiang K.-J.,Taipei Medical University | Chu H.,Institute of Aerospace Medicine | Chang H.-J.,Taipei Medical University | And 5 more authors.
International Journal of Geriatric Psychiatry | Year: 2010

Objectives: To examine the effects of reminiscence therapy on psychological well-being, depression, and loneliness among institutionalized elderly people. Methods: In an experimental study design, 92 institutionalized elderly people aged 65 years and over were recruited and randomly assigned to two groups. Those participants in the experimental group received reminiscence therapy eight times during 2 months to examine the effects of this therapy on their psychological well-being. Results: After providing the reminiscence therapy to the elderly in the experimental group, a significant positive short-term effect (3 months follow-up) on depression, psychological well-being, and loneliness, as compared to those in the comparison group was found. Conclusions: Reminiscence therapy in this study sample improved socialization, induced feelings of accomplishment in participants, and assisted to ameliorate depression. Copyright © 2009 John Wiley & Sons, Ltd.


Chung L.-Y.,Kaohsiung Medical University | Wang L.-C.,Chang Gung University | Chen C.-H.,Mei Ho Institute of Technology | Lin H.-Y.,Kaohsiung Medical University | Yen C.-M.,Kaohsiung Medical University
Redox Report | Year: 2010

The cerebrospinal fluid (CSF) of C57BL/6 mice infected with Angiostrongylus cantonensis was examined for kinetic changes in oxidative stress parameters, including reactive oxygen species (ROS), superoxide dismutase (SOD), catalase, malondialdehyde (MDA), 8-isoprostane, and 8-hydroxy-2′-deoxyguanosine (8-OHdG). The ROS increased gradually in the early stage of infection. During days 12-30 post-infection, the infected mice revealed ROS levels significantly higher than that in uninfected controls (P < 0.001). The ROS levels peaked at day 24 and then returned to that observed in uninfected controls at day 45 post-infection. The kinetics of MDA, 8-isoprostane, and 8-OHdG concentration changes observed in the CSF of the infected mice corresponded with kinetic changes in ROS levels. Thus, the excess ROS caused lipid peroxidation and DNA damage to cells in the central nervous system (CNS) of mice infected with A. cantonensis despite the increased antioxidant SOD and catalase enzyme activities during post-infection days 12-30. The oxidative stress in the CNS of C57BL/6 mice was apparently increased by diseases associated with A. cantonensis infection. © 2010 Maney Publishing.


Chen B.-W.,National Sun Yat - sen University | Chao C.-H.,National Sun Yat - sen University | Su J.-H.,Mei Ho Institute of Technology | Wen Z.-H.,National Sun Yat - sen University | And 2 more authors.
Organic and Biomolecular Chemistry | Year: 2010

Three novel eunicellin-based diterpenoids, namely klysimplexin sulfoxides A-C (1-3), were isolated from the cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly 1D and 2D-NMR experiments. Compounds 1-3 significantly inhibited the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells. Compound 3 also showed marked activity in inhibiting the expression of COX-2 protein in the same cells. © 2010 The Royal Society of Chemistry.


Yeh J.J.,Pingtung Christian Hospital | Yeh J.J.,Mei Ho Institute of Technology | Yeh J.J.,China Medical University at Taichung | Chen S.C.-C.,Pingtung Christian Hospital | And 6 more authors.
European Radiology | Year: 2010

Objective: This study aimed to determine whether characteristics detected by multi-detector computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary tuberculosis (PTB). Methods: Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2) smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images were analysed retrospectively for morphology, number, and segmental (lobe) distribution of lesions. Results: By multivariate analysis, consolidation over any segment of the upper, middle, or lingual lobes, cavitations, and clusters of nodules were associated with group 1, while centrilobular nodules were predictive of group 2. Using five independent variables associated with risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC curve analysis showed an area under the curve of 0.951±0.021 for this prediction model. With the ideal cutoff point score of 1, the sensitivity, specificity, and positive predictive values were 84.5%, 97.5%, and 98.0%, respectively. Conclusions: A model to predict smear-positive active PTB on the basis of findings from MDCT may be a useful tool for clinical decisions about isolating patients pending sputum smear results. © European Society of Radiology 2010.


Wang Y.-C.,National Cheng Kung University | Kuo Q.-Y.,National Cheng Kung University | Chen C.,National Cheng Kung University | Chen C.,Mei ho Institute of Technology
AIP Conference Proceedings | Year: 2010

Mechanically buckled components may exhibit negative stiffness, namely negative slopes of load-displacement curves. Negative-stiffness components are unstable under load control, but may be stabilized when embedded with positive-stiffness matrix in a form of composite. Negative-stiffness composites have been shown to exhibit stiffness greater than diamond, and their viscoelastic damping can be largely increased due to the negative-stiffness inclusions. Combining the negative-stiffness effects and nano-scale systems, we studied the mechanical system of a buckled carbon nanotube being compressed laterally with a carbon fullerene with molecular-dynamics (MD) simulations to explore its high effective stiffness. The buckled nanotube was laterally compressed with a C20 fullerene. The fullerenes are attached to the buckled nanotube via the carbon-carbon bonding with the Tersoff-Brenner interatomic potential. The force exerting on the fullerene and the corresponding displacement are monitored and recorded at each time step of 1 femtosecond. The constant particle number, volume and temperature (NVT) ensemble is chosen for the MD calculations. It is found the overall spring constant of the composite system under the loading condition is about 10 N/m in the initial loading state. Further loading on the system shows the overall stiffness is negative, indicating the interaction between the positive- and negative-stiffness was dominated by the nanotube. The calculated total load reveals that it is a low energy cost process to revert a buckled nanotube to an unbuckled state after creating a local buckling. © 2010 American Institute of Physics.


Yeh J.J.,Pingtung Christian Hospital | Yeh J.J.,Mei Ho Institute of Technology | Yeh J.J.,China Medical University at Taichung | Yu J.K.-L.,Pingtung Christian Hospital | And 5 more authors.
European Journal of Radiology | Year: 2012

Purpose: This study evaluates the use of high-resolution computed tomography (HRCT) to differentiate smear-positive, active pulmonary tuberculosis (PTB) from other pulmonary infections in the emergency room (ER) setting. Methods: One hundred and eighty-three patients diagnosed with pulmonary infections in an ER were divided into an acid fast bacillus (AFB) smear-positive, active PTB group (G1 = 84) and a non-AFB smear-positive, pulmonary infection group (G2 = 99). HRCT images from a 64-Multidetector CT were analyzed, retrospectively, for the morphology, number, and segmental distribution of pulmonary lesions. Results: Utilizing multivariate analysis, five variables were found to be independent risk factors predictive of G1: (1) consolidation involving the apex segment of right upper lobe, posterior segment of the right upper lobe, or apico-posterior segment of the left upper lobe; (2) consolidation involving the superior segment of the right or left lower lobe; (3) presence of a cavitary lesion; (4) presence of clusters of nodules; (5) absence of centrilobular nodules. A G1 prediction score was generated based on these 5 criteria to help differentiate G1 from G2. The area under the receiver operating characteristic (ROC) curve was 0.96 ± 0.012 in our prediction model. With an ideal cut-off point score of 3, the specificity, sensitivity, positive predictive value (PPV), and negative predictive value (NPV) are 90.9%, 96.4%, 90.0% and 96.8%, respectively. Conclusion: The use of this AFB smear-positive, active PTB prediction model based on 5 key HRCT findings may help ER physicians determine whether or not isolation is required while awaiting serial sputum smear results in high risk patients. © 2010 Elsevier Ireland Ltd. All rights reserved.

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