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Wang G.-H.,Chia Nan University of Pharmacy and Science | Huang H.-C.,Cheng Shiu University | Su J.-H.,Mei Ho Institute of Technology | Wu Y.-C.,Kaohsiung Medical University | Sheu J.-H.,National Sun Yat - sen University
Chemical and Pharmaceutical Bulletin | Year: 2010

Six new sesquiterpenoids, paralemnolins J-O (1-6), along with one novel norsesquiterpenoid, paralemnolin P (7), have been isolated from the soft coral Paralemnalia thyrsoides. The structures of metabolites 1-7 were established on the basis of extensive NMR study and chemical methods. The structure of 5 was further confirmed by a single-crystal X-ray analysis. Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is described. © 2010 Pharmaceutical Society of Japan. Source

Niu S.F.,Taipei Medical University | Chung M.-H.,Taipei Medical University | Chen C.-H.,Mei Ho Institute of Technology | Hegney D.,National University of Singapore | And 2 more authors.
Journal of Nursing Research | Year: 2011

Background: Disrupted circadian rhythm, especially working night duty together with irregular sleep patterns, sleep deprivation, and fatigue, creates an occupational health risk associated with diminished vigilance and work performance. Purpose: This study reviewed the effect of shift rotations on employee cortisol profile, sleep quality, fatigue, and attention level. Methods: Researchers conducted a systematic review of relevant articles published between 1996 and 2008 that were listed on the following databases: SCOPUS, OVID, Blackwell Science, EBSCO Host, PsycINFO, Cochrane Controlled Trials Register, and CEPS. A total of 28 articles were included in the review. Results: Previous research into the effects of shift work on cortisol profiles, sleep quality, fatigue, and attention used data assessed at evidence Levels II to IV. Our systematic review confirmed a conflict between sleepYwake cycle and lightYdark cycle in night work. Consequences of circadian rhythm disturbance include disruption of sleep, decreased vigilance, general feeling of malaise, and decreased mental efficiency. Shift workers who sleep during the day (day sleepers) experience cortisol secretion increases, which diminish the healing power of sleep and enjoy 1 to 4 hours less sleep on average than night sleepers. Sleep debt accumulation results in chronic fatigue. Prolonged fatigue and inadequate recovery result in decreased work performance and more incidents. Rotation from day shift to night shift and its effect on shiftworkers was a special focus of the articles retained for review. Conclusions: Disturbed circadian rhythm in humans has been associated with a variety of mental and physical disorders andmay negatively impact on work safety, performance, and productivity. Copyright © 2011 Taiwan Nurses Association. Source

Yeh J.J.,Pingtung Christian Hospital | Yeh J.J.,Mei Ho Institute of Technology | Yeh J.J.,China Medical University at Taichung | Chen S.C.-C.,Pingtung Christian Hospital | And 6 more authors.
European Radiology | Year: 2010

Objective: This study aimed to determine whether characteristics detected by multi-detector computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary tuberculosis (PTB). Methods: Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2) smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images were analysed retrospectively for morphology, number, and segmental (lobe) distribution of lesions. Results: By multivariate analysis, consolidation over any segment of the upper, middle, or lingual lobes, cavitations, and clusters of nodules were associated with group 1, while centrilobular nodules were predictive of group 2. Using five independent variables associated with risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC curve analysis showed an area under the curve of 0.951±0.021 for this prediction model. With the ideal cutoff point score of 1, the sensitivity, specificity, and positive predictive values were 84.5%, 97.5%, and 98.0%, respectively. Conclusions: A model to predict smear-positive active PTB on the basis of findings from MDCT may be a useful tool for clinical decisions about isolating patients pending sputum smear results. © European Society of Radiology 2010. Source

Chen B.-W.,National Sun Yat - sen University | Chao C.-H.,National Sun Yat - sen University | Su J.-H.,Mei Ho Institute of Technology | Wen Z.-H.,National Sun Yat - sen University | And 2 more authors.
Organic and Biomolecular Chemistry | Year: 2010

Three novel eunicellin-based diterpenoids, namely klysimplexin sulfoxides A-C (1-3), were isolated from the cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly 1D and 2D-NMR experiments. Compounds 1-3 significantly inhibited the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells. Compound 3 also showed marked activity in inhibiting the expression of COX-2 protein in the same cells. © 2010 The Royal Society of Chemistry. Source

Wang Y.-C.,National Cheng Kung University | Kuo Q.-Y.,National Cheng Kung University | Chen C.,National Cheng Kung University | Chen C.,Mei Ho Institute of Technology
AIP Conference Proceedings | Year: 2010

Mechanically buckled components may exhibit negative stiffness, namely negative slopes of load-displacement curves. Negative-stiffness components are unstable under load control, but may be stabilized when embedded with positive-stiffness matrix in a form of composite. Negative-stiffness composites have been shown to exhibit stiffness greater than diamond, and their viscoelastic damping can be largely increased due to the negative-stiffness inclusions. Combining the negative-stiffness effects and nano-scale systems, we studied the mechanical system of a buckled carbon nanotube being compressed laterally with a carbon fullerene with molecular-dynamics (MD) simulations to explore its high effective stiffness. The buckled nanotube was laterally compressed with a C20 fullerene. The fullerenes are attached to the buckled nanotube via the carbon-carbon bonding with the Tersoff-Brenner interatomic potential. The force exerting on the fullerene and the corresponding displacement are monitored and recorded at each time step of 1 femtosecond. The constant particle number, volume and temperature (NVT) ensemble is chosen for the MD calculations. It is found the overall spring constant of the composite system under the loading condition is about 10 N/m in the initial loading state. Further loading on the system shows the overall stiffness is negative, indicating the interaction between the positive- and negative-stiffness was dominated by the nanotube. The calculated total load reveals that it is a low energy cost process to revert a buckled nanotube to an unbuckled state after creating a local buckling. © 2010 American Institute of Physics. Source

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