Metropolitan Government of Nashville-Davidson (balance), TN, United States
Metropolitan Government of Nashville-Davidson (balance), TN, United States

Meharry Medical College, located in Nashville, Tennessee, United States, is a graduate and professional institution affiliated with the United Methodist Church whose mission is to educate healthcare professionals and scientists. Founded in 1876 as the Medical Department of Central Tennessee College, it was the first medical school in the South for African Americans, though not the first medical school for African-Americans in the nation; the Howard University College of Medicine was chartered in 1868, for example.Meharry Medical College was chartered separately in 1915. It is currently the largest private historically black institution in the United States solely dedicated to educating healthcare professionals and scientists.Meharry Medical College includes a medical school, dental school, graduate school, and an allied health school. The degrees that Meharry offers include Doctor of Medicine , Doctor of Dental Surgery , Master of Science in Public Health , Master of Science , and Doctor of Philosophy degrees. Meharry is the second largest educator of African-American medical doctors and dentists in the United States. Also, it is the largest producer of African Americans with Masters in Public Health and Ph.D.s in biomedical science.Journal of Health Care for the Poor and Underserved is a public health journal owned by and edited at Meharry Medical College. Wikipedia.

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Whitty J.E.,Meharry Medical College
Clinical Obstetrics and Gynecology | Year: 2010

Women with cystic fibrosis (CF) are living to childbearing age and many have successful pregnancies. Preconception care with optimization of pulmonary function, eradication of pulmonary infection, improved nutritional status, and diabetes care improve fertility and pregnancy outcome. Women with CF, poor pulmonary function and nutrition, and less than ideal body weight are more likely to suffer adverse outcomes. Women with CF and pulmonary hypertension risk mortality. Individuals with CF and end stage lung disease have improved survival after lung transplant. Women with lung transplants can have successful pregnancy, but the risk of organ rejection and death are high. © 2010, Lippincott Williams & Wilkins.

Xie H.,Meharry Medical College
Future Microbiology | Year: 2015

Porphyromonas gingivalis is one of the keystone pathogens associated with chronic periodontitis. All P. gingivalis strains examined thus far produce outer membrane vesicles. Recent studies have found that vesicles possess some well-known virulence factors of P. gingivalis such as adhesins, toxins and proteolytic enzymes. Carrying most of the characteristic features of their parent P. gingivalis cells, vesicles communicate with host cells and other members of microbial biofilms, resulting in the transmission of virulence factors into these host cells and the formation of pathogenic bacteria-dominated microbial communities. An in-depth understanding of both the nature and role of vesicles in the pathogenicity of P. gingivalis is both important and timely, particularly when speaking of periodontitis and its related systemic effects. © 2015 Future Medicine Ltd.

Nowicki B.,Meharry Medical College
Advances in experimental medicine and biology | Year: 2013

In this chapter, we present a concise historic prospective and a summary of accumulated knowledge on steroid hormones, DAF expression, and therapeutic implication of steroid hormone treatment on multiple pathologies, including infection and the host-pathogen interactions. DAF/CD55 plays multiple physiologic functions including tissue protection from the cytotoxic complement injury, an anti-inflammatory function due to its anti-adherence properties which enhance transmigration of monocytes and macrophages and reduce tissue injury. DAF physiologic functions are essential in many organ systems including pregnancy for protection of the semiallogeneic fetus or for preventing uncontrolled infiltration by white cells in their pro- and/or anti-inflammatory functions. DAF expression appears to have multiple regulatory tissue-specific and/or menstrual cycle-specific mechanisms, which involve complex signaling mechanisms. Regulation of DAF expression may involve a direct or an indirect effect of at least the estrogen, progesterone, and corticosteroid regulatory pathways. DAF is exploited in multiple pathologic conditions by pathogens and viruses in chronic tissue infection processes. The binding of Escherichia coli bearing Dr adhesins to the DAF/CD55 receptor is DAF density dependent and triggers internalization of E. coli via an endocytic pathway involving CD55, lipid rafts, and microtubules. Dr+ E. coli or Dr antigen may persist in vivo in the interstitium for several months. Further understanding of such processes should be instrumental in designing therapeutic strategies for multiple conditions involving DAF's protective or pathologic functions and tailoring host expression of DAF.

Juarez P.,Meharry Medical College
Journal of Health Care for the Poor and Underserved | Year: 2013

The exposome paradigm provides a new approach for conceptualizing and analyzing the impact of single exposures on health outcomes. This article describes the methods used to sequence the public health exposome and implications for the dynamic, multi-dimensional data information system developed by investigators at Meharry Medical College. © Meharry Medical College.

Membranous nephropathy (MN), a major cause of nephrotic syndrome, is a non-inflammatory immune kidney disease mediated by IgG antibodies that form glomerular subepithelial immune complexes. In primary MN, autoantibodies target proteins expressed on the podocyte surface, often phospholipase A2 receptor (PLA2R1). Pathology is driven by complement activation, leading to podocyte injury and proteinuria. This article overviews the mechanisms of complement activation and regulation in MN, addressing the paradox that anti-PLA2R1 and other antibodies causing primary MN are predominantly (but not exclusively) IgG4, an IgG subclass that does not fix complement. Besides immune complexes, alterations of the glomerular basement membrane (GBM) in MN may lead to impaired regulation of the alternative pathway (AP). The AP amplifies complement activation on surfaces insufficiently protected by complement regulatory proteins. Whereas podocytes are protected by cell-bound regulators, the GBM must recruit plasma factor H, which inhibits the AP on host surfaces carrying certain polyanions, such as heparan sulfate (HS) chains. Because HS chains present in the normal GBM are lost in MN, we posit that the local complement regulation by factor H may be impaired as a result. Thus, the loss of GBM HS in MN creates a micro-environment that promotes local amplification of complement activation, which in turn may be initiated via the classical or lectin pathways by subsets of IgG in immune complexes. A detailed understanding of the mechanisms of complement activation and dysregulation in MN is important for designing more effective therapies. © 2016 Borza.

Though sex differences in pain and analgesia are known, underlying mechanisms remain elusive. This study addresses the selective contribution of membrane estrogen receptors (mERs) and mER-initiated non-genomic signaling mechanisms in our previously reported estrogen-induced attenuation of α2-adrenoceptor-mediated antinociception. By selectively targeting spinal mERs in ovariectomized female rats using β-estradiol 6-(O-carboxy-methyl)oxime bovine serum albumin (E2BSA) (membrane impermeant estradiol analog), and ERα selective agonist 4,4',4″-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT), ERβ selective agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN), G-protein-coupled estrogen receptor 30 (GPR30) agonist G1 and Gq-coupled mER (Gq-mER) agonist STX, we provide strong evidence that Gq-mER activation may solely contribute to suppressing clonidine (an α2-adrenoceptor agonist)-induced antinociception, using the nociceptive tail-flick test. Increased tail-flick latencies (TFLs) by intrathecal (i.t.) clonidine were not significantly altered by i.t. PPT, DPN, or G1. In contrast, E2BSA or STX rapidly and dose-dependently attenuated clonidine-induced increase in TFL. ICI 182,780, the ER antagonist, blocked this effect. Consistent with findings with the lack of effect of ERα and ERβ agonists that modulate receptor-regulated transcription, inhibition of de novo protein synthesis using anisomycin also failed to alter the effect of E2BSA or STX, arguing against a contribution of genomic mechanisms. Immunoblotting of spinal tissue revealed that mER activation increased levels of phosphorylated extracellular signal-regulated kinase (ERK) but not of protein kinase A (PKA) or C (PKC). In vivo inhibition of ERK with U0126 blocked the effect of STX and restored clonidine antinociception. Although estrogen-induced delayed genomic mechanisms may still exist, data presented here indicate that Gq-mER may solely mediate estradiol-induced attenuation of clonidine antinociception via a rapid, reversible, and ERK-dependent, non-genomic mechanism, suggesting that Gq-mER blockade might provide improved analgesia in females. © 2014 IBRO.

Matthews-Juarez P.,Meharry Medical College
Journal of Health Care for the Poor and Underserved | Year: 2013

In the NIMHD-funded Health Disparities Research Center of Excellence at Meharry, faculty and scholars are trained to better address environmental health issues by integrating longitudinal, multi-systemic, spatially, and temporally referenced analytical methods. These methods include computational, multilevel, and spatial analyses through a transdisciplinary team model. © Meharry Medical College.

Sheng L.,Meharry Medical College
Toxicological sciences : an official journal of the Society of Toxicology | Year: 2010

Gene by environment interactions (G × E) are thought to underlie neurodevelopmental disorder, etiology, neurodegenerative disorders, including the multiple forms of autism spectrum disorder. However, there is limited biological information, indicating an interaction between specific genes and environmental components. The present study focuses on a major component of airborne pollutants, polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene [B(a)P], which negatively impacts cognitive development in children who have been exposed in utero. In our study, prenatal exposure of Cpr(lox/lox) timed-pregnant dams to B(a)P (0, 150, 300, and 600 μg/kg body weight via oral gavage) on embryonic day (E14-E17) consistent with our susceptibility-exposure paradigm was combined with the analysis of a replicated autism risk gene, the receptor tyrosine kinase, Met. The results demonstrate a dose-dependent increase in B(a)P metabolite generation in B(a)P-exposed Cpr(lox/lox) offspring. Additionally, a sustained persistence of hydroxy metabolites during the onset of synapse formation was noted, corresponding to the peak of Met expression. Prenatal B(a)P exposure also downregulated Met RNA and protein levels and dysregulated normal temporal patterns of expression during synaptogenesis. Consistent with these data, transcriptional cell-based assays demonstrated that B(a)P exposure directly reduces human MET promoter activity. Furthermore, a functional readout of in utero B(a)P exposure showed a robust reduction in novel object discrimination in B(a)P-exposed Cpr(lox/lox) offspring. These results confirm the notion that common pollutants, such as the PAH B(a)P, can have a direct negative impact on the regulated developmental expression of an autism risk gene with associated negative behavioral learning and memory outcomes.

News Article | February 27, 2017

Bishop Joseph W. Walker, III, senior pastor of Mount Zion Baptist Church, will bring his inspirational message of hope to millions; the program will launch Sunday, March 5 at 6:30 a.m. EST/5:30 a.m. CST NASHVILLE, TN--(Marketwired - Feb 27, 2017) - Bishop Joseph W. Walker, III, Nashville-based Senior Pastor of Mount Zion Baptist Church and Presiding Bishop of Full Gospel Baptist Fellowship International, will become the new featured minister on Black Entertainment Television (BET), called "The Relevant Word." He will be bringing his message of hope in Jesus Christ to homes across the country beginning Sunday, March 5. Bishop Walker follows in the footsteps of other influential black ministers who have regularly hosted programs on BET. Bishop Walker's theme, explored weekly, will be "hope" and his messages will encourage listeners to believe in a better life and a better world regardless of circumstances -- whether economic hardship, political turmoil, mental anxiety, or physical illness. Bishop Walker will help listeners gain a greater understanding of the biblical definition of hope as a "confident expectation" that, even though aspects of life are unknown and unclear, we are born to fulfill a true destiny. "I am so honored to be the featured minister for 'The Relevant Word,' and I'm extremely grateful to BET for giving me this national platform to make a difference in people's lives," said Bishop Walker. "Most importantly, I am eager to encourage listeners across the country to live in hope. Through Jesus Christ, we can come to view the uncertainties of life in a more positive light, believing that God has a greater purpose for us." A native of Shreveport, Louisiana, Walker received a Bachelor's degree from Southern University in Baton Rouge; a Master of Divinity degree from Vanderbilt University and a Doctor of Ministry degree from Princeton Theological University. He also holds two honorary Doctorates from Meharry Medical College and Southern University. At the age of 24, Bishop Walker began his pastorate at Mount Zion with just 175 members. Today, the ministry stands at more than 30,000 souls with three locations in the Nashville area. Bishop Walker's stirring oratory and pastoral approach draw people of every age and from every walk of life to the Word of God. The Relevant Word set to premiere on March 5, 2017 and will air every Sunday at 6:30 a.m. EST/5:30 a.m. CST. For more information on Bishop Walker and Mount Zion Baptist Church, please visit, About Mt. Zion Baptist Church Mount Zion Baptist Church is a Word-centered ministry designed to evangelize the lost at any cost, equip and empower the people of God and provide holistic ministry to our community as well as the world. Seeking to minister to the total person, we are a multi-ethnic, multi-cultural ministry impacting the world in which we live with the uncompromising message of Jesus Christ. Committed to the spirit of excellence, we are striving to become an oasis of hope within the Nashville community by promoting and providing education and awareness, as well as financial independence. Mount Zion Baptist Church is one church located in the three locations and accessible virtually anywhere via to millions around the world.

The International Association of HealthCare Professionals is pleased to welcome Dana Aubert Truesdale, DDS, Dentist to their prestigious organization with her upcoming publication in The Leading Physicians of the World. Dr. Dana Aubert Truesdale is a highly trained and qualified dentist with an extensive expertise in all facets of her work, especially general, family, and cosmetic dentistry. Dr. Truesdale has been in practice for 13 years and is currently serving patients within her own private practice, Innovation Dental Center, located in Baltimore, Maryland. Dr. Truesdale attended Meharry Medical College School of Dentistry in Nashville, Tennessee, graduating with her Doctor of Dental Surgery Degree in 2004. Following her graduation, Dr. Truesdale subsequently completed her residency at the University of Mississippi Medical Center in Jackson, Mississippi. In addition to her clinical practice, Dr. Truesdale serves as Captain in the United States Army National Guard, and received a Diploma of Ministerial Studies from the Spirit of Faith Bible Institute. She is a Certified Provider in Clear Correct and 6 Month Smiles, and attributes her success to her parents, her upbringing, and her life experiences. Dr. Truesdale is a member of the Dream Makers Network Foundation, which encourages personal self-development, and is also a Community Service Advocate. She is very passionate about serving others and helping them achieve healthy, beautiful smiles, and was recognized as one of Baltimore’s Top 3 Dentists. In her free time, Dr. Truesdale enjoys traveling. Learn more about Dr. Truesdale here: and be sure to read her upcoming publication in The Leading Physicians of the World. is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review. features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit

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