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Bano T.,Meerut Institute of Engineering and Technology | Yadav G.,Meerut Institute of Engineering and Technology | Dudhe R.,Galgotias University
Global Journal of Pharmacology | Year: 2013

A simple and rapid UV-spectrophotometer estimation method for the evaluation of Oseltamivir Phosphate is used in the treatment and prophylaxis of both influenza A and influenza B viruses has been developed and assessed. The proposed methods were successfully applied for the estimation of Oseltamivir Phosphate in commercial pharmaceutical preparation with UV detection at 217 nm. A Shimadzu 1700 UV-visible spectrophotometer with 1cm matched quartz cells and distilled water solvent were employed in this method. Developed methods obeyed Beer's law in the concentration range of 10 to 70ìg/ml having correlation coefficient of 0.999. Method was validated statistically. Percentage recovery of the drug for the proposed method ranged from (99.85%) indicating no interference of the excipients. The developed method was validated with respect to linearity, precision, accuracy (recovery), limit of detection (LOD) and limit of quantitation (LOQ). © IDOSI Publications, 2013.

Srivastava D.,Meerut Institute of Engineering and Technology
Asia-Pacific Journal of Chemical Engineering | Year: 2015

In sugar industries, a decrease in the exit liquor concentration is observed because of fouling in multiple-effect evaporator (MEE) systems, which finally decreases the yield of the MEE system. In the present work, a time-dependent exhaust steam temperature profile has been developed to compensate the ill effect of fouling. In the suggested temperature profile, the temperature of exhaust steam has been raised daily throughout the cycle of operation to achieve a constant exit liquor concentration. Further, the main drawback with this strategy is the increase in fouling resistance. For this purpose, an increase in foulant thickness has been determined, and it is found that only 0.4-mm foulant thickness has been increased with the suggested strategy, and it will not cost any extra effort in cleaning, and with this strategy, constant exit liquor concentration can be achieved. Copyright © 2014 Curtin University of Technology and John Wiley & Sons, Ltd. © 2014 Curtin University of Technology and John Wiley & Sons, Ltd.

Chauhan A.,Meerut Institute of Engineering and Technology | Sharma P.K.,Meerut Institute of Engineering and Technology | Kaushik N.,Meerut Institute of Engineering and Technology
International Journal of ChemTech Research | Year: 2011

The aim of this review is to provide an overview of diverse pharmacological activities of pyrazole moiety. This review highlighted recent reports of antimicrobial, anticancer, ACE inhibitory, antiviral as well as anti-inflammatory activities of pyrazole. The purpose of this review was to collate literature work reported by researchers on pyrazole for their varoius pharmacological activities and also reported recent efforts made on this moiety.

Shalini K.,Meerut Institute of Engineering and Technology | Kumar N.,Meerut Institute of Engineering and Technology | Drabu S.,M.S.I.P. | Sharma P.K.,Meerut Institute of Engineering and Technology
Beilstein Journal of Organic Chemistry | Year: 2011

Several five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacological activity of the triazole moiety which exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcal meningitis, aspergillosis etc. However, mortality due to these infections even with antifungal therapy is still unacceptably high. Therefore, the development of new antifungal agents targeting specific fungal structures or functions is being actively pursued. Rapid developments in molecular mycology have led to a concentrated search for more target antifungals. Although we are entering a new era of antifungal therapy in which we will continue to be challenged by systemic fungal diseases, the options for treatment will have greatly expanded. © 2011 Shalini et al; licensee Beilstein-Institut.

Gaddam S.V.K.,Meerut Institute of Engineering and Technology
International Journal of Network Security | Year: 2010

This paper puts forth a fresh methodology for the secure storage of fingerprint template by generating Secured Feature Matrix and keys for cryptographic techniques applied for data Encryption or Decryption with the aid of cancellable biometric features. Conventional techniques depend on biometric features like face, fingerprint, hand geometry, iris, signature, keystroke, voice and the like for the extraction of key information. If a Biometric Key is missing or stolen, it is lost perpetually and possibly for every application where the biometric is utilized, since a biometric is permanently linked with a user and cannot be altered. In this paper we propose a technique to produce cancellable key from fingerprint so as to surmount these problems. The flexibility and dependability of cryptography is enhanced with the utilization of cancellable biometric features. There are several biometric systems in existence that deal with cryptography, but the proposed cancellable biometric system introduces a novel method to generate Cryptographic Key. We have as well discussed about the Security analysis of the projected Cancellable Biometric System.

Do T.V.,Budapest University of Technology and Economics | Chakka R.,Meerut Institute of Engineering and Technology
Computer Communications | Year: 2010

Optical packet and burst switching have been proposed for networks because of the increased demand for capacity to transport traffic generated by various applications at present and in future. In optical packet switching networks the payload and the header of a packet are conveyed in the same channel, while burst switching networks allow the separate transportation of the payload and the header of bursts. In this paper we propose a queueing model for an optical node with a number of wavelengths and a buffer made from Fiber Delay Loops (FDL). We also apply negative customers in the queueing model in order to account for the loss of bursts due to the limitation related to the FDL (i.e. bursts can stay in a FDL buffer only for a limited period of time). Numerical results based on the analytical model are compared to the results obtained by simulation of optical burst switching nodes with the FDL buffer and input traffic using packet traces from the Internet Traffic Archive, which shows the accuracy of the proposed model. © 2010 Elsevier B.V. All rights reserved.

Banerjee P.S.,Birla Institute of Technology | Sharma P.K.,Meerut Institute of Engineering and Technology
Medicinal Chemistry Research | Year: 2012

Epilepsy is a common neurological condition, affecting 0.5 to 1% of the population worldwide. The chemical diversity and various mechanisms of action of anticonvulsants make it difficult to find a common way of identifying new drugs. Novel anticonvulsant agents are discovered through conventional screening and/or structure modification. Rational drug design process of a new anticonvulsant could be achieved in several ways. The first strategy is the identification of new targets through better understanding of molecular mechanisms of epilepsy. Another way is to modify already existing drugs and formulations. The new AEDs and anticonvulsant agents representing various structures have been reviewed in the present review. The newer agents include sulfonamides, amino acids, amides (analogs of g-vinyl GABA, N-benzylamides, 2,6-dimethylanilides, carboxyamides, hydroxyamides, alkanoamides); heterocyclic agents ((arylalkyl) imidazoles, tricyclic indoles, indazoles, arylpiperazine and piperazines, pyrrolidin-2,5-diones, pyridazinone, lactams, semi- thiosemicarbazones, thiadiazoles, quinazolin-4(3H)-ones, 2,5-disubstituted 1,2,4-thiadiazoles, xanthones, derivatives of isatin), enaminones, imidooxy compounds, and valproic acid derivatives. These new structural classes of compounds can prove useful for the design of future targets and development of new drugs. © Springer Science+Business Media, LLC 2011.

Yadav R.K.,Meerut Institute of Engineering and Technology | Gupta S.P.,Meerut Institute of Engineering and Technology | Sharma P.K.,Meerut Institute of Engineering and Technology | Patil V.M.,Bharat Institute of Technology
Current Medicinal Chemistry | Year: 2011

Matrix metalloproteinases (MMPs) are a large family of calcium-dependent zinc- containing endopeptidases, which are responsible for the tissue remodeling and degradation of the extracellular matrix (ECM), including collagens, elastins, gelatin, matrix glycoproteins, and proteoglycan. The inappropriate expression of these MMPs constitutes part of the pathogenic mechanism in several diseases, therefore they are subject to inhibition. They can be inhibited by endogenous proteinase inhibitors such as 2-macroglobulin or by the family of tissue inhibitors of metalloproteinases (TIMPs), which are glycoproteins of molecular weight 21-30 kDa, consisting of 184- 194 amino acid residues. Recently, many different classes of synthetic inhibitors have been developed in which the hydroxamic acidbased class of compounds (hydroxamates) have been most widely studied, as their hydroxamic acid group (CONHOH) enables them to act as a bidentate ligand with the zinc ion present in MMPs, leading to much stronger interaction with the receptor as compared to any other class of inhibitors. The present review describes in detail the recent development on this class of MMP inihibitors. Compounds like 12,17e, f, g and h, 45j, 45k, 50f, 62a, 63a, and 63b have been reported to be highly promising for further development. © 2011 Bentham Science Publishers Ltd.

Gupta S.P.,Meerut Institute of Engineering and Technology
EXS | Year: 2012

Matrix metalloproteinases (MMPs) regulate a wide range of biological functions; hence, they have invited great attention for the studies on their structures and functions, and since their overactivation leads to several diseases, the design and discovery of their potent inhibitors have become the need of the day. Since there have been so far discovered 28 different types of human MMPs, the specificity of binding of inhibitors with each different MMP needs special attention. The chapter presents the X-ray crystallographic and NMR studies on three-dimensional structures of a number of MMPs to reveal their catalytic site, subsites, specificity of binding with substrate and inhibitors, and catalytic mechanism. In addition to catalytic site, MMPs possess some subsites designated by unprimed and primed S, e.g., S1, S2, S3 and S1', S2', S3'. Among these, the S1' pocket varies the most among the different MMPs varying in both the amino acid makeup and depth of the pocket (shallow, intermediate, and deep pocket MMPs). This, along with the flexibility in the structures of MMPs, could be of great help in the design and the development of selective MMP inhibitors (MMPIs). The determination of affinity of inhibitors and the cleavage position of peptide substrates is mainly based on P1'-S1' interaction (P1', the group in inhibitor or substrate binding to S1' pocket of the enzyme), and it is the main determinant for the affinity of inhibitors and the cleavage position of peptide substrates.

Gupta S.P.,Meerut Institute of Engineering and Technology
Chemical Reviews | Year: 2012

A study was conducted to perform quantitative structure-activity relationship (QSAR) studies on Na +, K +-ATPase inhibitors. Investigations revealed that Na +,K +-ATPase led to an increase in intracellular accumulation of Na + ions and depletion of K + ions, resulting in an enhancement in the amount of Ca 2+ ions an increase in the force of contraction. The increase in the force of myocardial contraction led to increased cardiac output, decreased heart size, venous pressure, and blood volume, diuresis and relief of edema in patients with heart failure. QSAR studies provided significant information about the mechanism of drug-receptor interaction and rationalize structural modifications to find potent drugs. These studies explained the observed variations in biological activities of a group of congeners in terms of molecular variations caused by a change in the substituents.

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