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Patil V.M.,Bharat Institute of Technology | Gupta S.P.,Meerut Institute of Engineering and Technology | Samanta S.,Birla Institute of Technology | Masand N.,L L R M Medical College
Current Medicinal Chemistry | Year: 2011

Hepatitis C virus (HCV) infection has emerged as one of the most significant disease to affect humans. Despite its large medical and economical impact, there are no vaccines or efficient therapies without major side effects. The HCV non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase responsible for the complete copy of the RNA viral genome and is a target of choice for the development of anti-HCV drugs. Although many small molecules have been identified as allosteric inhibitors of NS5B, very few are active in clinical applications. Developments in the field have prompted us to review the research work on HCV NS5B polymerase inhibitors, especially their structure activity relationships and molecular modeling studies. This review will focus on the journey of drug discovery of HCV NS5B inhibitors covering both nucleoside and non-nucleosides. © 2011 Bentham Science Publishers. Source

Banerjee P.S.,Birla Institute of Technology | Sharma P.K.,Meerut Institute of Engineering and Technology
Medicinal Chemistry Research | Year: 2012

Epilepsy is a common neurological condition, affecting 0.5 to 1% of the population worldwide. The chemical diversity and various mechanisms of action of anticonvulsants make it difficult to find a common way of identifying new drugs. Novel anticonvulsant agents are discovered through conventional screening and/or structure modification. Rational drug design process of a new anticonvulsant could be achieved in several ways. The first strategy is the identification of new targets through better understanding of molecular mechanisms of epilepsy. Another way is to modify already existing drugs and formulations. The new AEDs and anticonvulsant agents representing various structures have been reviewed in the present review. The newer agents include sulfonamides, amino acids, amides (analogs of g-vinyl GABA, N-benzylamides, 2,6-dimethylanilides, carboxyamides, hydroxyamides, alkanoamides); heterocyclic agents ((arylalkyl) imidazoles, tricyclic indoles, indazoles, arylpiperazine and piperazines, pyrrolidin-2,5-diones, pyridazinone, lactams, semi- thiosemicarbazones, thiadiazoles, quinazolin-4(3H)-ones, 2,5-disubstituted 1,2,4-thiadiazoles, xanthones, derivatives of isatin), enaminones, imidooxy compounds, and valproic acid derivatives. These new structural classes of compounds can prove useful for the design of future targets and development of new drugs. © Springer Science+Business Media, LLC 2011. Source

Gaddam S.V.K.,Meerut Institute of Engineering and Technology | Lal M.,The New School
International Journal of Network Security | Year: 2010

This paper puts forth a fresh methodology for the secure storage of fingerprint template by generating Secured Feature Matrix and keys for cryptographic techniques applied for data Encryption or Decryption with the aid of cancellable biometric features. Conventional techniques depend on biometric features like face, fingerprint, hand geometry, iris, signature, keystroke, voice and the like for the extraction of key information. If a Biometric Key is missing or stolen, it is lost perpetually and possibly for every application where the biometric is utilized, since a biometric is permanently linked with a user and cannot be altered. In this paper we propose a technique to produce cancellable key from fingerprint so as to surmount these problems. The flexibility and dependability of cryptography is enhanced with the utilization of cancellable biometric features. There are several biometric systems in existence that deal with cryptography, but the proposed cancellable biometric system introduces a novel method to generate Cryptographic Key. We have as well discussed about the Security analysis of the projected Cancellable Biometric System. Source

Do T.V.,Budapest University of Technology and Economics | Chakka R.,Meerut Institute of Engineering and Technology
Computer Communications | Year: 2010

Optical packet and burst switching have been proposed for networks because of the increased demand for capacity to transport traffic generated by various applications at present and in future. In optical packet switching networks the payload and the header of a packet are conveyed in the same channel, while burst switching networks allow the separate transportation of the payload and the header of bursts. In this paper we propose a queueing model for an optical node with a number of wavelengths and a buffer made from Fiber Delay Loops (FDL). We also apply negative customers in the queueing model in order to account for the loss of bursts due to the limitation related to the FDL (i.e. bursts can stay in a FDL buffer only for a limited period of time). Numerical results based on the analytical model are compared to the results obtained by simulation of optical burst switching nodes with the FDL buffer and input traffic using packet traces from the Internet Traffic Archive, which shows the accuracy of the proposed model. © 2010 Elsevier B.V. All rights reserved. Source

Gupta S.P.,Meerut Institute of Engineering and Technology
Chemical Reviews | Year: 2012

A study was conducted to perform quantitative structure-activity relationship (QSAR) studies on Na +, K +-ATPase inhibitors. Investigations revealed that Na +,K +-ATPase led to an increase in intracellular accumulation of Na + ions and depletion of K + ions, resulting in an enhancement in the amount of Ca 2+ ions an increase in the force of contraction. The increase in the force of myocardial contraction led to increased cardiac output, decreased heart size, venous pressure, and blood volume, diuresis and relief of edema in patients with heart failure. QSAR studies provided significant information about the mechanism of drug-receptor interaction and rationalize structural modifications to find potent drugs. These studies explained the observed variations in biological activities of a group of congeners in terms of molecular variations caused by a change in the substituents. Source

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