Meenakshi University

Chennai, India

Meenakshi University

Chennai, India
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Brindha E.,Anna University | Rajasekaran R.,Anna University | Aruna P.,Anna University | Koteeswaran D.,Meenakshi University | Ganesan S.,Anna University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2017

Urine has emerged as one of the diagnostically potential bio fluids, as it has many metabolites. As the concentration and the physiochemical properties of the urinary metabolites may vary under pathological transformation, Raman spectroscopic characterization of urine has been exploited as a significant tool in identifying several diseased conditions, including cancers. In the present study, an attempt was made to study the high wavenumber (HWVN) Raman spectroscopic characterization of urine samples of normal subjects, oral premalignant and malignant patients. It is concluded that the urinary metabolites flavoproteins, tryptophan and phenylalanine are responsible for the observed spectral variations between the normal and abnormal groups. Principal component analysis-based linear discriminant analysis was carried out to verify the diagnostic potentiality of the present technique. The discriminant analysis performed across normal and oral premalignant subjects classifies 95.6% of the original and 94.9% of the cross-validated grouped cases correctly. In the second analysis performed across normal and oral malignant groups, the accuracy of the original and cross-validated grouped cases was 96.4% and 92.1% respectively. Similarly, the third analysis performed across three groups, normal, oral premalignant and malignant groups, classifies 93.3% and 91.2% of the original and cross-validated grouped cases correctly. © 2016


Subash K.R.,Meenakshi University | Ramesh K.S.,Meenakshi University | Charian B.V.,Meenakshi University | Britto F.,Meenakshi University | And 2 more authors.
International Journal of Pharmacology | Year: 2011

The study was conducted to evaluate the hepatoprotective activity of Solanum nigrum and Cichorium intybus. Hepatotoxicity was induced in albino rats with 1:1 (v/v) mixture of CCL 4 in olive oil, administered at the dose of 1.5 mg kg -1 i.p on 7th day. The extract of Solanum nigrum and Cichorium intybus were administered to the experimental rats. The hepatoprotective effect of these extracts was evaluated by the assay of serum protein, Serum bilirubin and serum enzymes like Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Markers for oxidative stress like Glutathione (GSH), Superoxide Dismutase (SOD), Lipid Peroxidase (LPO) and histopathological studies of liver. In the groups where hepatic injury induced by CCL 4 and extract were given simultaneously, the toxic effect of CCL 4 was controlled significantly (<0.05) by maintenance of structural integrity of hepatocyte cell membrane and normalisation of functional status of liver. Histology of liver sections from Solanum nigrum and Cichorium intybus + CCL 4 treated rats revealed moderate centrilobular hepatocytes degeneration, few areas of congestion with mild fatty changes. The extract of Solanum nigrum and Cichorium intybus possess significant hepatoprotective activity in comparison to standard drug Silymarin. © 2011 Asian Network for Scientific Information.


Jagan Rao N.,Meenakshi University | Subash K.R.,Meenakshi University | Sandeep Kumar K.,Meenakshi University
International Journal of Pharmacology | Year: 2012

There is a long and venerable history of the use of plants to improve dental health and promote oral hygiene. Plants contain phytochemicals such as alkaloids, tannins, essential oils and flavonoids which have pronounced antimicrobial activity. Plants have also been incorporated into dentifrices and have been used to provide natural chewing gums for oral hygiene, to treat toothache, gingivitis and periodontal disease. There is a potentially valuable role for Phytotherapy in assisting with the management of gingival and periodontal diseases. The evidence and research which supports such a role for a few plants and plant products has been reviewed in this study. © 2012 Asian Network for Scientific Information.


Vishali N.,University of Madras | Kamakshi K.,Meenakshi University | Suresh S.,University of Madras | Prakash S.,University of Madras
Phytotherapy Research | Year: 2011

Depletion of estrogens occurs in women during menopause, while in experimental animals, oophorectomy is a common method to deplete the animals of their gonadal hormones. Recently, phytoestrogens derived from plants have been tried as estrogen substitutes during menopause. In the present study an isoflavones methanol extract from red clover Trifolium pratense (Linn.) was administered orally (500 mg/kg of body weight) to ovariectomized (OVX) and normal (controls) rats for 90 and 180 days. Their pain threshold was monitored using tail flicking and formalin test methods. Observations showed that the OVX rat pain threshold was reduced due to estrogen deprivation, whereas the pain threshold levels in OVX rats treated with isoflavones extract was similar to the control animals. The present study demonstrated the influence of phytoestrogen on long-term OVX rats in pain perception in the absence of ovarian estrogen and without toxic side effects. However, the actions of gonadal hormones on nociceptive axis are myriad and complex, so further studies on the exact physiological mechanism of the phytoestrogen action on nociceptive axis is warranted. © 2010 John Wiley & Sons, Ltd.


Endodontic management of teeth with aberrant root canal morphology can be challenging. This article presents a case in which multiple angulated radiographs and a dental operating microscope clearly revealed the presence of 3 root canals in a right mandibular central incisor with 2 different canal patterns. This case report emphasizes the importance of utilizing a dental operating microscope to understand unusual root canal morphology.


Spoorthy E.,Meenakshi University | Velmurugan N.,Meenakshi University | Ballal S.,Meenakshi University | Nandini S.,Meenakshi University
International Endodontic Journal | Year: 2013

Aim: To evaluate the effect of an apical negative pressure system, a passive ultrasonic irrigation system and a combination of both apical negative pressure and passive ultrasonic irrigation on the penetration of the irrigating contrast solution (ICS) up to working length and into simulated lateral canals. Methodology: The root canals of 64 single-rooted teeth were instrumented using the ProTaper rotary system. In each sample, three simulated lateral canals were created at 2, 4 and 6 mm levels from the root apex using a 06-size C+ file (Dentsply Maillefer, Ballaigues, Switzerland). Samples were randomly assigned into 4 experimental groups (n = 16): group I - conventional needle irrigation, group II - passive ultrasonic irrigation, group III - apical negative irrigation system and group IV - combination of passive ultrasonic irrigation and apical negative pressure irrigation system. To examine irrigating solution penetration, Indian ink was mixed with 5.25% NaOCl and delivered into the root canals. Samples were then assessed by direct observation of the images taken using Canon EOS rebel T3. The depth of penetration of ICS up to the working length and into the simulated lateral canals was analysed using chi-squared tests. Results: The combination (ANP and PUI) and ANP group had significantly deeper ICS penetration up to the working length (P < 0.001). The combination (ANP and PUI) and the PUI group exhibited significantly greater ICS penetration into lateral canals at the 6 mm level (P < 0.001). At the 4 and 2 mm levels, the combination of ANP and PUI had significantly greater ICS penetration into the lateral canals than the other groups (P < 0.001). Conclusions: The combination of ANP and PUI was the only group able to achieve irrigating contrast solution penetration both up to the working length and into lateral canals. © 2013 International Endodontic Journal.


Rajendiran T.V.,Pachaiyappas College | Rajendiran T.V.,Meenakshi University | Anbuselvan C.,Pachaiyappas College
Asian Journal of Chemistry | Year: 2010

Three new azoaromatic polyimides were synthesized by condensing 3,3′,4,4′-azobenzene tetra carboxylic dianhydride and 4,4′-diaminodiphenyl/ 4,4′-diaminoazobenzene/2,2-bis(4-p- aminophenoxy) phenyl]- propane. These polyimides were drawn into fibres with different experimental conditions. Their physical, mechanical and morphological properties were studied. The structure of polyimides were also confirmed by pyrolysis-GC-mass spectra.


Ranjith D.,Meenakshi University | Ramya J.,Auxilium College Autonomous
International Journal of Applied Engineering Research | Year: 2014

Cloud computing is a scattered computing prototype which permits a third party to offer accomplished computer possessions in an on-bidding manner for people to track their own services. The supplier manages this by dynamic huge data centers of service computers, obligatory the economies of calibration to accusation its users for each unit usage time. So, in an approach, it is computer dealings. In Cloud Computing now a day's having more cloud applications. In the standard environment, the service vitality, elasticity, choices and flexibility suggest by this scalable technology are too attractive that makes the cloud computing to increasingly becoming a necessary part of the enterprise computing environment. Cloud computing facilities allow users to lease computing possessions from huge scale data centers operated by cloud service suppliers. Applying the cloud services, users can use a varied variety of applications enthusiastically and on-demand. In this paper explains about the features and survey of Dropbox and Google Drive in the real world. © Research India Publications.


Ashwinkumar V.,Meenakshi University | Krithikadatta J.,Meenakshi University | Surendran S.,Meenakshi University | Velmurugan N.,Meenakshi University
International Endodontic Journal | Year: 2014

Aim: To compare dentinal microcrack formation whilst using Ni-Ti hand K-files, ProTaper hand and rotary files and the WaveOne reciprocating file. Methodology: One hundred and fifty mandibular first molars were selected. Thirty teeth were left unprepared and served as controls, and the remaining 120 teeth were divided into four groups. Ni-Ti hand K-files, ProTaper hand files, ProTaper rotary files and WaveOne Primary reciprocating files were used to prepare the mesial canals. Roots were then sectioned 3, 6 and 9 mm from the apex, and the cut surface was observed under scanning electron microscope (SEM) and checked for the presence of dentinal microcracks. Results: The control and Ni-Ti hand K-files groups were not associated with microcracks. In roots prepared with ProTaper hand files, ProTaper rotary files and WaveOne Primary reciprocating files, dentinal microcracks were present. There was a significant difference between control/Ni-Ti hand K-files group and ProTaper hand files/ProTaper rotary files/WaveOne Primary reciprocating file group (P < 0.001) with ProTaper rotary files producing the most microcracks. No significant difference was observed between teeth prepared with ProTaper hand files and WaveOne Primary reciprocating files. Conclusion: ProTaper rotary files were associated with significantly more microcracks than ProTaper hand files and WaveOne Primary reciprocating files. Ni-Ti hand K-files did not produce microcracks at any levels inside the root canals. © 2013 International Endodontic Journal.


PubMed | Meenakshi University and SBV University
Type: Journal Article | Journal: Progress in orthodontics | Year: 2016

In this finite element (FE) study, the stress distribution and displacement pattern was evaluated in the mid-palatal area and around circum-maxillary sutures exerted by bone-borne palatal expander (BBPE) in comparison with conventional HYRAX rapid palatal expander in unilateral cleft lip and palate.Computed tomography scan images of a patient with unilateral cleft palate was used to create a FE model of the maxillary bone along with circum-maxillary sutures. A three-dimensional model of the conventional HYRAX (Hygienic Rapid Expander) expander and custom-made BBPE was created by laser scanning and programmed into the FE model.With the BBPE, the maximum stress was observed at the implant insertion site, whereas with the conventional HYRAX expander, it was at the dentition level. Among the circum-maxillary sutures, the zygomaticomaxillary suture experienced maximum stress followed by the zygomaticotemporal and nasomaxillary sutures. Displacement in the X-axis (transverse) was highest on the cleft side, and in the Y-axis (antero-posterior), it was highest in the posterior region in the BBPE.The total displacement was observed maximum in the mid-palatal cleft area in the BBPE, and it produced true skeletal expansion at the alveolar level without any dental tipping when compared with the conventional HYRAX expander.

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