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Ravish D.K.,Anna University | Shenbaga Devi S.,Anna University | Krishnamoorthy S.G.,Meenakshi Medical College Hospital and Research Institute
Biomedical Research (India) | Year: 2015

This paper deals with the wavelet analysis method for seizure detection in EEG time series and coherence estimation. The main part of the paper presents the basic principles of signal decomposition in connection with the EEG frequency bands. Wavelet analysis method has been used for detection of seizure onset. The wavelet filtered signal is used for the computation of spectral power ratio. The results show that our method can identify pre seizure, seizure, post seizure and non seizure phases. When dealing with seizure detection and prediction problems it is important to identify seizure precursor dynamics and necessary to identify information about onset and spread of seizures. Therefore in the second part the coherence and phase synchrony during pre seizure, seizure, post seizure and non seizure are computed. We expect this method to provide more insight into dynamic aspects of the seizure generating process. © 2015, Scientific Publishers of India. All rights reserved.

D'cruz S.M.,Sri Muthukumaran Medical College Hospital and Research Institute | Rajaratnam N.,Meenakshi Medical College Hospital and Research Institute
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2013

Background: Aging affects many functions including cognition. Changes in Memory, which is a cognitive function, occur in healthy aging. Aims & Objective: To determine the effect of aging on memory in normal non-demented subjects in South India using the Wechsler Memory Scale (WMS) and a test of Delayed Recall. Materials and Methods: The Wechsler Memory Scale and a test of Delayed Recall were administered to 50 controls aged 20-50 years (Group I), 50 subjects aged 60-75 years (Group II) and 50 subjects aged above 75 years (Group III). Results: There was a significant difference in the Wechsler Memory Scale raw scores of the controls (Group I) vs. subjects aged 60-75 years (Group II),with a p- value of 0.001; as well as between controls (Group I) vs. subjects aged above 75 years (Group III),with a p- value of 0.000. Comparison of the subset scores between controls and subjects (Group II + Group III) revealed a significant decline (p = 0.000) in all subsets except Orientation and Digit Span. Conclusion: Our study revealed that there were memory changes with aging with many aspects of memory declining with age and others showing no significant difference.

Sivalingam J.,Meenakshi Medical College Hospital and Research Institute | Kumar A.,Vidya Health Imaging
Journal of Clinical and Diagnostic Research | Year: 2015

Background: Tuberculous spondylitis is one of the commonest forms of skeletal tuberculosis in developing countries like India causing significant morbidity due to compression of spinal cord and adjacent nerve roots. Diagnosis and intervention at early stage can prevent permanent damage such as spinal deformity and neurological deficits. Aim: The purpose of this study was to demonstrate atypical MRI features in cases of tubercular spondylitis resembling neoplastic lesions and to stress that tuberculous spondylitis should be one of the differential diagnoses in any spinal pathology especially in developing countries. Materials and Methods: This was a prospective study done in the patients diagnosed as tuberculous spondylitis on 0.2 T Siemens MRI between June 2011 and December 2014 in a tertiary care hospital in India. Total 529 cases of tubercular spinal lesions were diagnosed. Out of which only 59 patients showed atypical features on MR imaging which resembled neoplastic lesions were included in the study. The diagnosis was confirmed by cytology, histopathology, serology and corroborative findings. Results: Lumbo-sacral region involvement (30.5%) is the commonest in our study followed by dorsal and cervical region. Multiple level lesions are seen in 14 cases (23.7%). All the 59 (100%) cases show no involvement of intervetebral disc. Posterior appendage involvement seen in 32 cases (54.2%). Soft tissue component seen in Intraspinal (37.2%) and paraspinal (45.7%) compartments. Cord compression seen in 19 cases (32.2%), out which only 7 cases (11.8%) shows cord oedema. Conclusion: On MRI, tubercular spondylitis may have variable pictures on imaging. For any spinal and paraspinal lesions, we should also consider the possibility of tubercular aetiology along with other. Since early diagnosis avoids unnecessary delay in the treatment thereby reducing morbidity and possible complications. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

Talikoti P.,Meenakshi Medical College Hospital and Research Institute | Bobby Z.,JIPMER | Hamide A.,JIPMER
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Pre-hypertension refers to blood pressure in the range of 120 to 139 mm of Hg/80 to 89 mm of Hg and its prevalence is increasing in India. Previous studies have documented the increase in homocysteine, C-reactive protein and insulin resistance and their role in the development of hypertension. In recent years much attention has been focused on subjects with prehypertension, as the risk for development of cardiovascular disease is higher in these subjects compared to those with normal blood pressure.Objectives: To evaluate the serum homocysteine, hs-CRP level and insulin resistance in subjects with prehypertension. Materials and Methods: Sixty prehypertensives and 32 normotensives were recruited according to Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of blood pressure (JNC 7) guidelines. Serum homocysteine, vitamin B12, folate, insulin, hs-CRP and lipid profile were analysed. Independent t-test was carried out to compare two groups and pearson correlation analyses were carried out between various parameters with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results: Cardiovascular risk factors like serum homocysteine, insulin resistance and inflammatory marker hs-CRP were significantly increased in prehypertensives. Total cholesterol, TG, LDL-C and VLDL-C were significantly increased when compared to normotensives. Serum homocysteine correlated positively and vitamin B12 and folate negatively with Systolic Blood Pressure. Conclusion: The present study concludes that the established cardiovascular risk factors, homocysteine, insulin resistance, and hs-CRP which have roles in the etiopathogenesis of hypertension, were elevated in subjects with prehypertension. Thus, early detection and life style modification may reduce the risk or delay the onset of hypertension and other cardiovascular complications.

Parkhad Suchitra B.,Meenakshi Medical College Hospital and Research Institute | Palve Sachin B.,Meenakshi Medical College Hospital and Research Institute | Dayoub M.A.L.,Consultant Neurologists
Biomedicine (India) | Year: 2014

Introduction: Obstructive sleep apnoea (OSA) is suggested to be associated with peripheralnerve damage. Aim: In this study, it was examined whether treatment for OSA has a possible beneficial effect on peripheral nerve function. Material and Methods: Participants were 50 patients with OSA and 50 controls matched for age and body mass index (BMI), all without any known cause of peripheral nerve damage. The sensory nerve action potential (SNAP) amplitudes of both peroneal nerves were determined. After 6 months of treatment for OSA, treatment compliance was evaluated and nerve conduction studies were repeated. Results: Patients with OSA had significantly lower mean (standard deviation) peroneal SNAP amplitudes than controls (6.3 (3.5) v 11.2 (5.0), p<0.001). Multivariate regression analysis including the variables age, BMI and Apnoea-Hypopnea Index (AHI) showed that both age (p<0.01) and AHI (p<0.05) were inversely related to the SNAP amplitude. On follow-up, the peroneal SNAP showed an increase of 2.6 mV on average (p<0.001). Multivariate regression analysis including the variables age, BMI, AHI, pretreatment SNAP and treatment compliance identified only treatment compliance as being significantly related to the SNAP increase (p≤0.005). Conclusion: OSA is an independent risk factor for axonal dysfunction of peripheral sensory nerves. Impaired neural function is at least partly reversible with treatment for sleep apnoea.

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