Sathish B.C.,Meenakshi Medical College |
Nagendra Gowda M.R.,Basaveshwara Medical College and Hospital |
Sambaji Rao M.,Basaveshwara Medical College and Hospital
Indian Journal of Public Health Research and Development | Year: 2015
Objective: To find out the place, time, methods used and month of attempting suicide. Type of Study: Cross Sectional Study. Setting: Bapuji and C.G Hospitals attached to JJM Medical College, Davanagere. Participants: 540 suicidal attempters admitted to emergency wards. Methodology: A pre tested questionnaire was used to interview the subjects relating the factors responsible for the attempt. The data thus obtained was compiled and analyzed. Statistical analysis: Proportions, Chi square test. Results: Evening and night times were preferred timings for the suicidal attempt. Home (73.3%) was the commonest place of the Suicidal Attempt in both the sexes. 22.6% of them committed the act on Wednesday compared to any other days of the week. Highest numbers of attempts were recorded in January, May and August. Conclusions: A national strategy for prevention of suicide is the need of the hour. So policy makers and programme managers have to give a serious thought in this regard. © 2015, Indian Journal of Public Health Research and Development. All Rights Reserved.
Seethalakshmi C.,Chettinad Dental College and Research Institute |
Koteeswaran D.,Meenakshi Ammal Dental College |
Chiranjeevi V.,Meenakshi Medical College
Journal of Clinical and Diagnostic Research | Year: 2014
Aim: The aim of this study is to compare the salivary urea, creatine, sodium, potassium and phosphate in pre dialysis and post dialysis state in end stage renal disease patients and compare with the serum counterpart.Materials and Method: The study group was selected from patients undergoing hemodialysis due renal failure of any cause, who are undergoing dialysis for at least one year duration in a private hospital in Chennai. The total number of subjects was thirty. The venous blood was collected from the study group just prior to the dialysis and after the dialysis from the venous catheter which is placed for the purpose of hemodialysis. The collected samples were immediately (within 15 min) submitted to the laboratory for the biochemical examination of urea, creatinine, sodium, potassium and phosphate by an automated biochemical analyser. Unstimulated whole saliva was collected by spitting method from study group both before and after dialysis. The collected samples were immediately submitted to the laboratory for the biochemical examination of urea, creatinine, sodium, potassium and phosphate by an automated biochemical analyser.Result: The paired t-test analysis was done in pre and post blood urea, creatinine, potassium and phosphate which was significant with a p-value of < 0.0001 and the same analysis was done in salivary urea in pre and post-dialysis state which also gave a significant reduction in the parameters with a p-value of < 0.0001. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved.
Govindaraj J.,Alapakkam Main Road |
Emmadi P.,Meenakshi Ammal Dental College |
Deepalakshmi,Meenakshi Ammal Dental College |
Rajaram V.,Meenakshi Ammal Dental College |
And 2 more authors.
Indian Journal of Experimental Biology | Year: 2010
The pathogenesis of periodontitis involves anaerobic oral bacteria as well as the host response to infection and several drugs have been developed which can curtail these deleterious effects. Proanthocyanidin, a novel flavanoid extracted from grape seeds, has been shown to provide a significant therapeutic effect on endotoxin (Escherichia coli) induced experimental periodontitis in rats. In this study, protective action of different doses of proanthocyanidins was investigated in blood by assaying the reactive oxygen species such as hydrogen peroxide, superoxide anion, myeloperoxidase and lipid peroxides, lysosomal enzyme activities such as cathepsin B, cathepsin D, (3-glucuronidase and acid phosphatase, nonenzymatic antioxidants such as ascorbic acid, a-tocopherol, ceruloplasmin, reduced glutathione and antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase and glutathione-s-transferase. Experimental periodontitis rats showed a reduction in body weight and body weight gain could be noticed when they were administered proanthocyanidins. The levels of reactive oxygen species and lysosomal enzymes were found to increase whereas antioxidant levels were decreased significantly in experimental periodontitis. Proanthocyanidins at an effective dose of 30mg/kg body weight, sc, for 30 days effected a decrease in serum reactive oxygen species, lipid peroxides, lysosomal enzymes, acute phase proteins and an increase in antioxidant levels. Histopathological evidence of experimental periodontitis showed cellular infiltration of inflammatory cells while proanthocyanidin treated groups demonstrated only scattered inflammatory cells and blood vessels. Thus, the results showed that dietary supplementation of proanthocyanidin enhanced the host resistance as well as the inhibition of the biological and mechanical irritants involved in the onset of gingivitis and the progression of periodontal disease.
Pramanik P.,Meenakshi Medical College |
Das U.,Pondicherry Institute of Medical science
Journal of Forensic Medicine and Toxicology | Year: 2011
A 22 year old man died on the spot in a road accident due to laceration injury over his neck. He was brushed by a passing car from behind while traveling on a bicycle. The deceased lost the control his bicycle and fell over the exposed metallic right end of the rotating handlebar of bicycle. He sustained a horizontally placed laceration injury over the front and both sides of the middle third of neck. Though the pediatric blunt abdominal trauma secondary to bicycle handlebar is widely reported but a fatal neck injury in an adult of this nature is certainly extraordinary and deserves mentioning in the forensic literature.
Vidyalakshmi K.,Meenakshi Ammal Dental College |
Kamalakannan P.,Meenakshi Medical College |
Viswanathan S.,Meenakshi Medical College |
Ramaswamy S.,Sri Lakshminarayana Institute of Medical science
Pharmacology Biochemistry and Behavior | Year: 2010
Objective: This study was designed to evaluate the antinociceptive action of four dihydroxy flavone derivatives; 3,3'-dihydroxy flavone, 5,6-dihydroxy flavone, 3,7-dihydroxy flavone and 6,3'-dihydroxy flavone and to investigate the mechanisms involved. Materials and methods: The antinociceptive effect of dihydroxy flavones was investigated in mice employing acetic acid induced abdominal constrictions, formalin-induced nociception, and hot plate assay procedures. The effects following pretreatment with naloxone, yohimbine, ondansetron, haloperidol, bicuculline and glibenclamide were also studied by acetic acid assay to reveal the involvement of opioid, adrenergic, tryptaminergic, dopaminergic, GABAergic or potassium channels respectively in the antinociceptive action of these compounds. Results: Dihydroxy flavone derivatives significantly reduced the number of abdominal constrictions in acetic acid assay. The paw licking response time during both the early and late phases of formalin-induced nociception was reduced in a dose dependent manner by dihydroxy flavones treatment. A significant increase in reaction time was also evident in hot plate assay after dihydroxy flavones treatment.The antinociceptive effect of dihydroxy flavones in the acetic acid assay was significantly attenuated by pretreatment with either naloxone or bicuculline. However, pretreatment of animals with yohimbine, ondansetron, haloperidol, or glibenclamide did not alter the response. Conclusion: All the four investigated dihydroxy flavones produced dose related antinociception through mechanisms that involve an interaction with opioid and GABAergic pathways. © 2010 Elsevier Inc.