Vidyalakshmi K.,Meenakshi Ammal Dental College |
Kamalakannan P.,Meenakshi Medical College |
Viswanathan S.,Meenakshi Medical College |
Ramaswamy S.,Sri Lakshminarayana Institute of Medical science
Pharmacology Biochemistry and Behavior | Year: 2010
Objective: This study was designed to evaluate the antinociceptive action of four dihydroxy flavone derivatives; 3,3'-dihydroxy flavone, 5,6-dihydroxy flavone, 3,7-dihydroxy flavone and 6,3'-dihydroxy flavone and to investigate the mechanisms involved. Materials and methods: The antinociceptive effect of dihydroxy flavones was investigated in mice employing acetic acid induced abdominal constrictions, formalin-induced nociception, and hot plate assay procedures. The effects following pretreatment with naloxone, yohimbine, ondansetron, haloperidol, bicuculline and glibenclamide were also studied by acetic acid assay to reveal the involvement of opioid, adrenergic, tryptaminergic, dopaminergic, GABAergic or potassium channels respectively in the antinociceptive action of these compounds. Results: Dihydroxy flavone derivatives significantly reduced the number of abdominal constrictions in acetic acid assay. The paw licking response time during both the early and late phases of formalin-induced nociception was reduced in a dose dependent manner by dihydroxy flavones treatment. A significant increase in reaction time was also evident in hot plate assay after dihydroxy flavones treatment.The antinociceptive effect of dihydroxy flavones in the acetic acid assay was significantly attenuated by pretreatment with either naloxone or bicuculline. However, pretreatment of animals with yohimbine, ondansetron, haloperidol, or glibenclamide did not alter the response. Conclusion: All the four investigated dihydroxy flavones produced dose related antinociception through mechanisms that involve an interaction with opioid and GABAergic pathways. © 2010 Elsevier Inc.
Sathish B.C.,Meenakshi Medical College |
Nagendra Gowda M.R.,Basaveshwara Medical College and Hospital |
Sambaji Rao M.,Basaveshwara Medical College and Hospital
Indian Journal of Public Health Research and Development | Year: 2015
Objective: To find out the place, time, methods used and month of attempting suicide. Type of Study: Cross Sectional Study. Setting: Bapuji and C.G Hospitals attached to JJM Medical College, Davanagere. Participants: 540 suicidal attempters admitted to emergency wards. Methodology: A pre tested questionnaire was used to interview the subjects relating the factors responsible for the attempt. The data thus obtained was compiled and analyzed. Statistical analysis: Proportions, Chi square test. Results: Evening and night times were preferred timings for the suicidal attempt. Home (73.3%) was the commonest place of the Suicidal Attempt in both the sexes. 22.6% of them committed the act on Wednesday compared to any other days of the week. Highest numbers of attempts were recorded in January, May and August. Conclusions: A national strategy for prevention of suicide is the need of the hour. So policy makers and programme managers have to give a serious thought in this regard. © 2015, Indian Journal of Public Health Research and Development. All Rights Reserved.
Pandian S.,Meenakshi Medical College |
Jayaraman T.,Meenakshi Medical College |
Rajendiran C.,Meenakshi Medical College
Journal of Orthopaedic Surgery | Year: 2016
We present a 22-year-old man with osteochondromatosis and osteochondroma involving bilateral patella and patellar tendon with restriction of joint movement and severe arthritis. © 2016, Hong Kong University Press. All rights reserved.
Govindaraj J.,Alapakkam Main Road |
Emmadi P.,Meenakshi Ammal Dental College |
Deepalakshmi,Meenakshi Ammal Dental College |
Rajaram V.,Meenakshi Ammal Dental College |
And 2 more authors.
Indian Journal of Experimental Biology | Year: 2010
The pathogenesis of periodontitis involves anaerobic oral bacteria as well as the host response to infection and several drugs have been developed which can curtail these deleterious effects. Proanthocyanidin, a novel flavanoid extracted from grape seeds, has been shown to provide a significant therapeutic effect on endotoxin (Escherichia coli) induced experimental periodontitis in rats. In this study, protective action of different doses of proanthocyanidins was investigated in blood by assaying the reactive oxygen species such as hydrogen peroxide, superoxide anion, myeloperoxidase and lipid peroxides, lysosomal enzyme activities such as cathepsin B, cathepsin D, (3-glucuronidase and acid phosphatase, nonenzymatic antioxidants such as ascorbic acid, a-tocopherol, ceruloplasmin, reduced glutathione and antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase and glutathione-s-transferase. Experimental periodontitis rats showed a reduction in body weight and body weight gain could be noticed when they were administered proanthocyanidins. The levels of reactive oxygen species and lysosomal enzymes were found to increase whereas antioxidant levels were decreased significantly in experimental periodontitis. Proanthocyanidins at an effective dose of 30mg/kg body weight, sc, for 30 days effected a decrease in serum reactive oxygen species, lipid peroxides, lysosomal enzymes, acute phase proteins and an increase in antioxidant levels. Histopathological evidence of experimental periodontitis showed cellular infiltration of inflammatory cells while proanthocyanidin treated groups demonstrated only scattered inflammatory cells and blood vessels. Thus, the results showed that dietary supplementation of proanthocyanidin enhanced the host resistance as well as the inhibition of the biological and mechanical irritants involved in the onset of gingivitis and the progression of periodontal disease.
Das S.,Meenakshi Medical College |
Kumar V.,Meenakshi Medical College
Journal of Forensic and Legal Medicine | Year: 2011
Injury to the male external genitalia and rupture of the diaphragm, are two very uncommon autopsy findings. To the best of our knowledge such a combination of injuries has not been reported in one particular case of autopsy in an English scientific literature. Degloving of the male external genitalia & rupture of the diaphragm may result from motor vehicle accidents, industrial accidents, gunshot & stab injuries. A rare case of traumatic degloving injury of the male external genitalia associated with rupture of the diaphragm & intermingling of thoracic & abdominal viscera is presented here. © 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
Sastry A.S.,Meenakshi Medical College |
Sandhya Bhat K.,Meenakshi Medical College |
Kumudavathi,Meenakshi Medical College
Journal of Clinical and Diagnostic Research | Year: 2013
Objective: The early laboratory diagnosis of Tuberculous Meningitis (TBM) is crucial, to start the antitubercular chemotherapy and to prevent its complications. However, the conventional methods are either less sensitive or time consuming. Hence, the diagnostic potentials of BacT/ALERT and Polymerase Chain Reaction (PCR) was evaluated in this study. Material and Method: The study group comprised of 62 cases and 33 controls. The cases were divided according to Ahuja's criteria into the confirmed (two cases), highly probable (19 cases), probable (26 cases) and the possible (15 cases) subgroups. Ziehl Neelsen's (ZN) and Auramine Phenol (AP) staining, Lowenstein Jensen (LJ) medium culture, BacT/ALERT and nested Polymerase Chain Reaction (PCR) which targeted IS6110 were carried out on all the patients. Observation and Results: The sensitivity of the LJ culture was 3.22%. BacT/ALERT showed a sensitivity and a specificity of 25.80% and 100% and those of nested PCR were found to be 40.32% and 96.97% respectively. The mean detection time of growth of the LJ culture was 31.28 days, whereas that of BacT/ALERT was 20.68 days. The contamination rate in the LJ culture and BacT/ALERT were 7.2% and 5.8% respectively. Conclusion: Nested PCR was found to be more sensitive, followed by BacT/ALERT as compared to the LJ culture and smear microscopy. As both false negative and false positive results have been reported for nested PCR, so it should not be used alone as a criterion for initiating or terminating the therapy, but it should be supported by clinical, radiological, cytological and other microbiological findings.
Srinivas E.R.,Meenakshi Medical College |
Balasubramaian C.,Meenakshi Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016
We have taken as our standard the definition of a human bite proposed by Tomasetti et al. (1972) namely "...One inflicted on a person by another person". Of all bites that of the human animal is the worst". (Mason quoted in 1941). This belief, once widely held, is no longer true. In this article we have analyzed 19 patients who presented to our casualty with facial human bites (of the 30 patients who presented with Human bite injury) with reference to their Age, Sex, Site of injury on their face was done. The intervention was done within 24hrs of the injury under antibiotic coverage and the outcome of the surgery-Infection rate, hospital stay, Morbidity was analysed. The infection rate in this series was only 2.5%.
PubMed | Meenakshi Medical College
Type: Journal Article | Journal: Journal of orthopaedic surgery (Hong Kong) | Year: 2016
We present a 22-year-old man with osteochondromatosis and osteochondroma involving bilateral patella and patellar tendon with restriction of joint movement and severe arthritis.
PubMed | Meenakshi Medical College and Sri Ramachandra University
Type: | Journal: Journal of clinical imaging science | Year: 2015
To determine the accuracy of High Resolution Computer Tomography (HRCT) temporal bone measurements in predicting the actual visualization of round window niche as viewed through posterior tympanotomy (i.e. facial recess).This is a prospective study of 37 cochlear implant candidates, aged between 1and 6 years, who were referred for HRCT temporal bone during the period December 2013 to July 2014. Cochlear implantation was done in 37 children (25 in the right ear and 12 in the left ear). The distance between the short process of incus and the round window niche and the distance between the oval window and the round window niche were measured preoperatively on sub-millimeter (0.7 mm) HRCT images. We classified the visibility of round window niche based on the surgical view (i.e. through posterior tympanotomy) during surgery into three types: 1) Type 1- fully visible, 2) Type 2- partially visible, and 3) Type 3- difficult to visualize. The preoperative HRCT measurements were used to predict the type of visualization of round window niche before surgery and correlated with the findings during surgery.The mean and standard deviation for the distance between the short process of incus and the round window niche and for the distance between the oval window and the round window niche for Types 1, 2, and 3 were 8.5 0.2 mm and 3.2 0.2 mm, 8.0 0.4 mm and 3.8 0.2 mm, 7.5 0.2 mm and 4.4 0.2 mm respectively, and showed statistically significant difference (P < 0.01) between them. The preoperative HRCT measurements had a sensitivity and specificity of 92.3% and 96.2%, respectively, in determining the actual visualization of round window niche.This study shows preoperative HRCT temporal bone measurements are useful in predicting the actual visualization of round window niche as viewed through posterior tympanotomy.
PubMed | Meenakshi Medical College and Chettinad Dental College and Research Institute
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015
The aim of this study is to compare the salivary urea, creatine, sodium, potassium and phosphate in pre dialysis and post dialysis state in end stage renal disease patients and compare with the serum counterpart.The study group was selected from patients undergoing hemodialysis due renal failure of any cause, who are undergoing dialysis for at least one year duration in a private hospital in Chennai. The total number of subjects was 30. The venous blood was collected from the study group just prior to the dialysis and after the dialysis from the venous catheter which is placed for the purpose of hemodialysis. The collected samples were immediately (within 15 min) submitted to the laboratory for the biochemical examination of urea, creatinine, sodium, potassium and phosphate by an automated biochemical analyser. Unstimulated whole saliva was collected by spitting method from study group both before and after dialysis. The collected samples were immediately submitted to the laboratory for the biochemical examination of urea, creatinine, sodium, potassium and phosphate by an automated biochemical analyser.The paired t-test analysis was done in pre and post blood urea, creatinine, potassium and phosphate which was significant with a p-value of < 0.0001 and the same analysis was done in salivary urea in pre and post-dialysis state which also gave a significant reduction in the parameters with a p-value of < 0.0001.