Idiculla J.J.,Meenakshi Ammal Dental College
International Journal of Oral and Maxillofacial Surgery | Year: 2012
Sinonasal papillomas are relatively rare, benign epithelial tumours of the nasal cavity. These lesions generate considerable interest because they are locally aggressive, have a tendency to recur and are associated with malignancy. The authors present a unique case of malignant sinonasal papilloma with neck metastasis. In the English literature only one case of such a presentation has been reported. © 2011 International Association of Oral and Maxillofacial Surgeons.
Vidyalakshmi K.,Meenakshi Ammal Dental College |
Kamalakannan P.,Meenakshi Medical College |
Viswanathan S.,Meenakshi Medical College |
Ramaswamy S.,Sri Lakshminarayana Institute of Medical science
Pharmacology Biochemistry and Behavior | Year: 2010
Objective: This study was designed to evaluate the antinociceptive action of four dihydroxy flavone derivatives; 3,3'-dihydroxy flavone, 5,6-dihydroxy flavone, 3,7-dihydroxy flavone and 6,3'-dihydroxy flavone and to investigate the mechanisms involved. Materials and methods: The antinociceptive effect of dihydroxy flavones was investigated in mice employing acetic acid induced abdominal constrictions, formalin-induced nociception, and hot plate assay procedures. The effects following pretreatment with naloxone, yohimbine, ondansetron, haloperidol, bicuculline and glibenclamide were also studied by acetic acid assay to reveal the involvement of opioid, adrenergic, tryptaminergic, dopaminergic, GABAergic or potassium channels respectively in the antinociceptive action of these compounds. Results: Dihydroxy flavone derivatives significantly reduced the number of abdominal constrictions in acetic acid assay. The paw licking response time during both the early and late phases of formalin-induced nociception was reduced in a dose dependent manner by dihydroxy flavones treatment. A significant increase in reaction time was also evident in hot plate assay after dihydroxy flavones treatment.The antinociceptive effect of dihydroxy flavones in the acetic acid assay was significantly attenuated by pretreatment with either naloxone or bicuculline. However, pretreatment of animals with yohimbine, ondansetron, haloperidol, or glibenclamide did not alter the response. Conclusion: All the four investigated dihydroxy flavones produced dose related antinociception through mechanisms that involve an interaction with opioid and GABAergic pathways. © 2010 Elsevier Inc.
Saraswathy Gopal K.,Meenakshi Ammal Dental College
Journal of Clinical and Diagnostic Research | Year: 2013
Background: The formation of dental tissues is a highly delicate and complex phenomenon. Any alteration in this process leads to various dental anomalies which affect the tooth number, size, shape and structure. Supernumerary teeth are one such anomaly which affects the tooth number. Supernumerary teeth can give rise to various complications and pathologies or they may have a familial/syndromic association. They may occur along with other dental anomalies. Thus, such teeth have a definite clinical significance. Aims and Objectives: The aim of the following study was to know the prevalence of the supernumerary teeth and the distribution of the cases according to the age, sex, jaw, region, eruption status, and the position. Materials and Methods: A total of 5000 patients were examined for a period of 1 year's duration and they were divided into different groups. Group I consisted of individuals who were aged between 5-20 years, Group II consisted of individuals who were aged between 21-40 years, and Group III consisted of individuals who were aged 41 years and above. The dental examination was conducted by using a mouth mirror and a probe, to determine the presence of supernumerary teeth. All the cases with supernumerary teeth were further observed and the details were recorded in a prepared porforma. These cases were also subjected to general physical examinations (to rule out any syndromes) and radiographic examinations. Photographs were also made. Conclusion: Although supernumerary teeth is an unusual anomaly, it is not as rare as was previously reported. The identification of this anomaly could provide a hint towards the possibility of complications, pathologies, other dental anomalies, syndromes and a familial association.
Seethalakshmi Ashokan C.,Chettinad Dental College |
Sreenivasan A.,Saveetha Dental College |
Saraswathy G.K.,Meenakshi Ammal Dental College
Journal of Clinical and Diagnostic Research | Year: 2014
Goldenhar's syndrome is a rare condition which was described initially in the early 1950s. It is characterized by a combination of anomalies: dermal epibulbar cysts, auricular appendices and malformations of the ears. In 1963, Gorlin suggested the name, oculo-auriculo-vertebral (OAV) dysplasia for this condition and he also included vertebral anomalies as signs of this syndrome. The aetiology of this rare disease has not been fully understood, as it has shown itself to be variable genetically and to be caused due to unclear reasons. Here, we are reporting two cases of Goldenhar's syndrome, where almost all the classical signs of this rare condition were present.
Sabarinath B.,Meenakshi Ammal Dental College |
Sivapathasundharam B.,Meenakshi Ammal Dental College |
Sathyakumar M.,SRM University
Journal of Histotechnology | Year: 2014
Fixation is an initial and important step in tissue processing for microscopical examination. The primary aim of fixation is to preserve the tissues in a life-like state, prevent bacterial putrefaction, prevent autolysis, and increase the refractive index of the tissue. The present study used a natural fixative instead of chemicals in order to prevent the deleterious effects of the chemical fixatives. The aim of this study was to determine the effectiveness of honey as a fixative, which is a natural product. A double-blind pilot study was conducted in the Department of Oral and Maxillofacial Pathology with the consent of patients who were visiting the hospital for other dental problems. A total of 30 specimens were taken, fixed using formalin and honey for 24 hours and then subjected to routine processing. The tissues were then stained with hematoxylin and eosin and were subjected to evaluation. Student's t-test was performed and analysis was done using Statistical Package for Social Science version 17 software. The numerical scores were graded from 1 to 4 and the mean standard deviation was calculated. The results showed statistically significant differences between honey and formalin samples for both nuclear details and cytoplasmic staining. Honey, as a tissue fixative, is easily available with no known toxicity and can be used as an alternative to formalin. However, studies should be done further to find methods to eliminate the disadvantages, such as homogenization, seen with the connective tissue. Furthermore, studies with large sample sizes are required to obtain more conclusive results. © National Society for Histotechnology 2014.
Anilkumar K.,Meenakshi Ammal Dental College
Oral health & preventive dentistry | Year: 2012
Probiotics are defined as live microorganisms which, when administered in appropriate amounts, confer a health benefit to the host. Although these organisms are naturally present in food and water, they can also be deliberately added to some foods because of their beneficial effects for human health. The potential application of probiotics for oral health has recently attracted the attention of several teams of researchers. However, only a few clinical studies have been conducted so far, and the results to date suggest that probiotics could be useful in preventing and treating oral infections, including dental caries, periodontal disease and halitosis. This article summarises the currently available data on the potential benefits of probiotics for oral health.
Saraswathi Gopal K.,Meenakshi Ammal Dental College |
Lankupalli A.M.,Meenakshi Ammal Dental College
Journal of Clinical and Diagnostic Research | Year: 2012
While the regeneration of a lost tissue is known to mankind for several years, it is only in the recent past that research on regenerative medicine/dentistry has gained momentum and eluded the dramatic yet scientific advancements in the field of molecular biology. The growing understanding of biological concepts in the regeneration of oral/dental tissues coupled with experiments on stem cells is likely to result in a paradigm shift in the therapeutic armamentarium of dental and oral diseases culminating in an intense search for biological solutions to biological problems. Stem cells have been successfully isolated from variety of human tissues including orofacial tissues. Initial evidence from pioneering studies has documented the likely breakthrough that stem cells offer for various life-threatening diseases that have so far defeated modern medical care. The evidence gathered so far has propelled many elegant studies exploring the role of stem cells and their manifold dental applications. This review takes you on a sojourn of the origin of stem cells, their properties, characteristics, current research, and their potential applications. It also focuses on the various challenges and barriers that we have to surmount before translating laboratory results to successful clinical applications heralding the dawn of moderan dentistry.
Krithikadatta J.,Meenakshi Ammal Dental College
Oral health & preventive dentistry | Year: 2013
To evaluate the efficacy of 10% casein phosphopeptide amorphous calcium phosphate complex (CPP-AC P) used alone or with fluoride as compared to fluoride mouthrinse for the remineralisation of occlusal white spot lesions in an in vivo pilot study. Forty-five subjects with occlusal white spot lesions (WSL) determined by visual examination and confirmed with Diagnodent were randomly divided into 3 groups: group 1: 10% CPP-AC P + 0.2% NaF; group 2: 10% CPPAC P; group 3: 0.5% NaF mouthrinse for 30 days. The pre-treatment and post-intervention Diagnodent values were tabulated and subjected to statistical analysis. Among the groups, the remineralising potential of 10% CPP-AC P + 0.2% NaF (group 1) and 10% CPP-AC P (group 2) were similar, however, both groups were superior to 0.5% NaF mouthrinse (group 3). The CCP-AC P technique is highly beneficial for the remineralisation of non-cavitated occlusal white spot lesions when compared to 0.5% NaF mouthrinse.
Chakravarthy R.,Meenakshi ammal dental college
Journal of Clinical and Diagnostic Research | Year: 2010
An intraoral sectional prosthesis was fabricated to restore more normal contour to a patient's ower lip that was compromised following a marginal mandibulectomy which was performed to eradicate a malignant neoplasm. The surgical resection compromised the lower lip on the affected side, because the marginal mandibular branch of the facial nerve was damaged during the surgical resection. The prosthesis successfully restored the lost lip support, reduced the incidence of lip biting and improved the patient's oral competency. This clinical report describes the procedure for making an intraoral magnet retained lip plumper prosthesis to improve patient aesthetics and oral function.
Sharma B.,Meenakshi Ammal Dental College |
Sriram G.,Meenakshi Ammal Dental College |
Saraswathi T.R.,Meenakshi Ammal Dental College |
Sivapathasundharam B.,Meenakshi Ammal Dental College
Indian Journal of Dental Research | Year: 2010
Objectives : Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC). Similarly, mast cells have also been reported to play a role in tumor progression and metastases by promoting angiogenesis. The present study aims at comparison of microvascular density (MVD) and mast cell density (MCD) in normal oral mucosa (NM) and among various grades of OSCC. Materials and Methods : MVD was assessed immunohistochemically using anti-Factor VIII related von Willebrand factor, and MCD using anti-mast cell tryptase in a study sample of 30 cases of OSCC and 10 cases of clinically normal oral mucosa. Results : The mast cells in normal oral mucosa and oral squamous cell carcinoma strongly expressed mast cell tryptase. The density of mast cells and micro vessels were significantly higher in OSCC compared to normal oral mucosa. The MCD and MVD were higher in moderately differentiated OSCC than in well differentiated OSCC ( P > 0.05) and normal oral mucosa ( P < 0.05). Pearson's correlation revealed a positive correlation between MCD and MVD ( r=0.33; P=0.077). Conclusion : These findings indicate that mast cells may play a role in up regulation of tumor angiogenesis in OSCC probably through mast cell tryptase.