Tomsk, Russia
Tomsk, Russia

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Udut V.V.,Tomsk State University | Tyutrin I.I.,Mednord Tekhnika | Solov'Ev M.A.,E D Goldberg Research Institute Of Pharmacology And Regenerative Medicine | Klimenkova V.F.,Mednord Tekhnika | And 4 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2015

Comparative analysis of the effectiveness of global tests for evaluation of the blood coagulation systems demonstrated the possibility of obtaining express data on hemostasis stages I-II and III when working with native substrate (whole blood). Changes in viscous characteristics of the whole blood recorded ex vivo during hemocoagulation allowed us to propose the concept of permanency of fi brinogenesis as the obligatory in vivo process determining the hemostatic potential, an integral characteristic of the hemocoagulation cycle providing suffi cient blood fl uidity and limiting extravasation of blood components under conditions of permeability disturbances and damage to the vascular wall. © 2015 Springer Science+Business Media New York.

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