Sinicrope F.A.,North Central Cancer Treatment Group |
Foster N.R.,North Central Cancer Treatment Group |
Yothers G.,National Surgery Adjuvant Breast and Bowel Project |
Benson A.,Eastern Cooperative Oncology Group |
And 6 more authors.
Cancer | Year: 2013
BACKGROUND: Although obesity is an established risk factor for developing colon cancer, its prognostic impact and relation to patient sex in colon cancer survivors remains unclear. METHODS: The authors examined the prognostic and predictive impact of the body mass index (BMI) in patients with stage II and III colon carcinoma (N = 25,291) within the Adjuvant Colon Cancer Endpoints (ACCENT) database. BMI was measured at enrollment in randomized trials of 5-fluorouracil-based adjuvant chemotherapy. Association of BMI with the time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS) were determined using Cox regression models. Statistical tests were 2-sided. RESULTS: During a median follow-up of 7.8 years, obese and underweight patients had significantly poorer survival compared with overweight and normal-weight patients. In a multivariable analysis, the adverse prognostic impact of BMI was observed among men but not among women (Pinteraction =.0129). Men with class 2 and 3 obesity (BMI ≥35.0 kg/m2) had a statistically significant reduction in DFS (hazard ratio [HR], 1.16; 95% confidence interval [CI], 1.01-1.33; P =.0297) compared with normal-weight patients. Underweight patients had a significantly shorter TTR and reduced DFS (HR, 1.18; 95% CI, 1.09-1.28; P <.0001) that was more significant among men (HR, 1.31; 95% CI, 1.15-1.50; P <.0001) than among women (HR, 1.11; 95% CI, 1.01-1.23; P =.0362; Pinteraction =.0340). BMI was not predictive of a benefit from adjuvant treatment. CONCLUSIONS: Obesity and underweight status were associated independently with inferior outcomes in patients with colon cancer who received treatment in adjuvant chemotherapy trials. © 2013 American Cancer Society.
Bechah Y.,Mediterranean University |
Paddock C.D.,Centers for Disease Control and Prevention |
Capo C.,Mediterranean University |
Mege J.-L.,Mediterranean University |
Raoult D.,Mediterranean University
PLoS ONE | Year: 2010
Brill-Zinsser disease, the relapsing form of epidemic typhus, typically occurs in a susceptible host years or decades after the primary infection; however, the mechanisms of reactivation and the cellular reservoir during latency are poorly understood. Herein we describe a murine model for Brill-Zinsser disease, and use PCR and cell culture to show transient rickettsemia in mice treated with dexamethasone >3 months after clinical recovery from the primary infection. Treatment of similarly infected mice with cyclosporine failed to produce recrudescent bacteremia. Therapy with doxycycline for the primary infection prevented recrudescent bacteremia in most of these mice following treatment with dexamethasone. Rickettsia prowazekii (the etiologic agent of epidemic typhus) was detected by PCR, cell culture, and immunostaining methods in murine adipose tissue, but not in liver, spleen, lung, or central nervous system tissues of mice 4 months after recovery from the primary infection. The lungs of dexamethasone-treated mice showed impaired expression of β-defensin transcripts that may be involved in the pathogenesis of pulmonary lesions. In vitro, R. prowazekii rickettsiae infected and replicated in the murine adipocyte cell line 3T3-L1. Collectively these data suggest a role for adipose tissue as a potential reservoir for dormant infections with R. prowazekii. © 2010 Bechah et al.
Ruffini E.,University of Turin |
Van Raemdonck D.,University Hospitals Leuven |
Detterbeck F.,Yale University |
Rocco G.,Italian National Cancer Institute |
And 2 more authors.
Journal of Thoracic Oncology | Year: 2011
Introduction: Management of thymoma has largely been based on single-institution retrospective, observational studies. The European Society of Thoracic Surgeons (ESTS) Thymic Working Group has investigated the current practice among ESTS members. Methods: A questionnaire divided into seven sections with 24 questions was designed, and it was delivered to ESTS members. Results: Forty-four centers replied to the questionnaire. The results indicate that there is a general agreement concerning (1) the value of computed tomography scan for preoperative assessment; (2) the uselessness of a routine histologic confirmation before surgery; (3) the role of the World Health Organization classification; (4) the importance of complete and extended resection; (5) the role of surgery for recurrent disease; and (6) the need of a multidisciplinary team, including thoracic surgeons, pathologists, medical, and radiation oncologists. On the other hand, there is still a considerable debate about (1) the role of positron emission tomography scan for preoperative assessment; (2) a consistent and reliable staging system; (3) the usefulness of postoperative treatments for stages II and III diseases; (4) the management of type C thymoma; and (5) the role of extrapleural pneumonectomy for stage IVA thymoma. Conclusions: The survey provides a large, multiinstitutional overview of the clinical practice in the management of thymic tumors by ESTS members. Responses show some areas of agreement along with several areas of controversy. It is conceivable that a consequent step forward will be the creation of a collaborative effort within the ESTS and with other organizations for the creation of standard recommendations and guidelines for the management of thymic malignancies. Copyright © 2011 The International Association for the Study of Lung Cancer.
Clay E.,Mediterranean University |
Falissard B.,French Institute of Health and Medical Research |
Moore N.,French Institute of Health and Medical Research |
Toumi M.,University Claude Bernard Lyon 1
European Journal of Clinical Pharmacology | Year: 2013
Background: Benzodiazepines (BZD) and benzodiazepine receptor agonists (zolpidem, zaleplon, zopiclone, altogether Z-drugs) are most commonly prescribed for the treatment of insomnia. However, long-term use of BZD/Z-drugs is associated with major adverse events including, but not limited to, falls and fractures, domestic and traffic accidents, confusion, cognitive impairment, Alzheimer's disease and cancer. The prolonged use of these drugs is thought to be related to severe withdrawal symptoms and potential dependency. The chronic and extensive use of BZD/Z drugs has become a public health issue and has led to multiple campaigns to reduce both prescription and consumption of BZD/Z-drugs. Prolonged-release (PR) melatonin is the first of a new class of melatonin receptor agonist drugs that has demonstrated clinically relevant efficacy on improving quality of sleep and morning alertness, with a good safety profile. Objective: This study aimed to analyze and evaluate the impact of anti-BZD/Z-drugs campaigns and the availability of alternative pharmacotherapy (PR-melatonin) on the consumption of BZD and Z-drugs in several European countries. Methods: Annual sales data from nine European countries were extracted from the IMS sales database and analyzed to determine whether trends in use of these treatment options were attributed to campaigns and/or availability and affordability of safer alternatives on the market. Results: Campaigns aiming to reduce the use of BZD/Z-drugs failed when they were not associated with the availability and market uptake of PR-melatonin. The reimbursement of PR-melatonin supports better penetration rates and a higher reduction in sales for BZD/Z-drugs. © 2013 The Author(s).
Guzeller C.O.,Mediterranean University |
Cosguner T.,Pamukkale University
Cyberpsychology, Behavior, and Social Networking | Year: 2012
The aim of this study was to evaluate the psychometric properties of the Problematic Mobile Phone Use Scale (PMPUS) for Turkish Adolescents. The psychometric properties of PMPUS were tested in two separate sample groups that consisted of 950 Turkish high school students. The first sample group (n=309) was used to determine the factor structure of the scale. The second sample group (n=461) was used to test data conformity with the identified structure, discriminant validity and concurrent scale validity, internal consistency reliability calculations, and item statistics calculations. The results of exploratory factor analyses indicated that the scale had three factors: interference with negative effect, compulsion/persistence, and withdrawal/tolerance. The results showed that item and construct reliability values yielded satisfactory rates in general for the three-factor construct. On the other hand, the average variance extracted value remained below the scale value for three subscales. The scores for the scale significantly correlated with depression and loneliness. In addition, the discriminant validity value was above the scale in all sub-dimensions except one. Based on these data, the reliability of the PMPUS scale appears to be satisfactory and provides good internal consistency. Therefore, with limited exception, the PMPUS was found to be reliable and valid in the context of Turkish adolescents. © Copyright 2012, Mary Ann Liebert, Inc.
Thomas P.A.,Mediterranean University |
Brouchet L.,Rangueil Larrey University Hospital
Thoracic Surgery Clinics | Year: 2010
Chest wall reconstructions can be complex and challenging procedures, especially when huge thoracic defects have been generated by radical excisions. Nonrigid reconstructions with meshes or patches have the goal of avoiding a lung hernia caused by the chest wall defect, or preventing the impaction of the scapula in case of posterior chest wall resections, especially when the resection is extended down to the 5th and 6th ribs. Large anterior and lateral resections result in thoracic instability and alteration of pulmonary physiology, and render intrathoracic structures vulnerable to external impact. They necessitate rigid reconstructions according to several techniques using alloplastic materials (eg, methyl methacrylate-based customized plates or neo-ribs, osteosynthesis systems, or dedicated prosthesis). Nowadays, the availability of these multiple, possibly combined, more adapted, and better tolerated materials have pushed past the limits of resection to those involving soft tissue coverage. © 2010 Elsevier Inc.
Lay-Ekuakille A.,University of Salento |
Palamara I.,Mediterranean University |
Caratelli D.,Technical University of Delft |
Morabito F.C.,Mediterranean University
Review of Scientific Instruments | Year: 2013
Subterranean waters are often polluted by industrial and anthropic effluents that are drained in subsoil. To prevent and control pollution, legislations of different developed countries require an online monitoring measurement, especially for detecting organic solvents (chlorinated and unchlorinated ones). Online measurements include both real-time and no real-time measurements. In general, it is difficult to implement real-time measurements in stricto sensu for online acquisitions on aqueous effluents since they need to be processed by a modeling. This research presents an experimental measurement system based on infrared (IR) spectroscopy for aqueous effluents containing hydrocarbons and capable of displaying excellent values of pollutant concentrations even in instable conditions; the system is able to detect pollutants either in laminar or turbulent flow. The results show the possibility of avoiding the use of "Pitot tube" that is employed to create a stagnation point in order to convert kinetic energy into potential one. This conversion allows the transformation of a turbulent flow in a laminar flow making easy measurement of pollutants included in an aqueous effluent. Obviously, "Pitot tube" is also used for other fluid effluents. The obtained results have been compared with those produced by means of sophisticated IR instrumentation for laboratory applications. © 2013 American Institute of Physics.
Habib M.,Mediterranean University |
Giraud K.,Mediterranean University
Handbook of Clinical Neurology | Year: 2013
Developmental dyslexia (DD) is a specific and persistent disability affecting the acquisition of written language. Prevalence is estimated to be between 5% and 17% of school-aged children; it therefore represents a major public health issue. Neurological in origin, its causes are unknown, although there is a clear genetic component. Diagnosis rests upon the use of standardized tests and tools to assess reading and spelling, as well as phonological skills. The importance of early diagnosis cannot be overemphasized and much current research is focusing on screening and prediction, particularly through use of objective imaging techniques (e.g., EEG/MEG), which have implicated cortical abnormalities in central auditory processing (Giraud et al., 2005, 2008). Remediation should be intensive, begin as early as possible, and be tailored to the individual. Phonics based treatments are most effective and several variants, incorporating temporal auditory, articulatory, or multisensory training exercises, have been developed or proposed. Clinical improvements in phonological skills and reading with such treatments have been shown to correlate with changes in the brains of dyslexic children in several functional imaging studies. © 2013 Elsevier B.V.
Hale A.S.,St Martins Hospital |
Azorin J.M.,Mediterranean University |
Lemming O.M.,Lundbeck |
International Clinical Psychopharmacology | Year: 2012
This study assessed the safety and tolerability of sertindole in the long-term treatment of schizophrenia. An open-label, noncomparative, flexible-dose study was carried out in 11 European countries. Upon completion of an 8-week, haloperidol-referenced randomized clinical trial with sertindole, patients were offered sertindole maintenance treatment up to 18 months. In total, 294 patients were enrolled, of whom 237 (81%) had received sertindole and 57 (19%) had received haloperidol in the lead-in trial. The modal dose during the maintenance period was 16 mg/day. Patients showed therapeutic improvement indicated by significant decreases in the Positive And Negative Syndrome Scale and Clinical Global Impression 'severity-of-illness' scores. An adverse event was the primary reason for withdrawal in 13% of patients. The most common adverse events were fatigue and weight gain, both with incidences of 14%. The incidence of extrapyramidal symptoms was 18%, and 11% of the patients required anticholinergic medication. No statistically significant changes were observed in laboratory values or vital signs, but the mean serum prolactin levels decreased. The mean change in weight from baseline to the last assessment was 2.7 kg. The largest weight increase was observed in patients who were underweight at baseline. Long-term treatment with sertindole was safe and well tolerated, and patients showed clinical improvement beyond acute treatment. © 2012 Wolters Kluwer Health.
Thomas P.A.,Mediterranean University
Thoracic Surgery Clinics | Year: 2011
Thymic epithelial tumors (TETs) are rare thoracic malignancies, with an overall incidence of 1.5 per million people. The TET Registry Project aims at federating an international network to provide a resource to support studies on the epidemiology and clinical management and monitoring some standards of clinical care of these tumors. Recorded data span all the specifications of the management of TET: paraneoplastic syndromes, histologic subtypes, diagnostic and staging issues, multimodal treatment strategies, and exceptional surgeries and therapies. Data collection for the registry is done both prospectively and retrospectively through different paths to allow the involvement of as many centers as possible, including data-sharing arrangements with some already established databases. This ambitious project implies the early setting of strong quality assurance measures looking at completeness, consistency, and accuracy of the data. These measures require a significant and long-term financial support that will also be free of possible sources of conflicts of interests. © 2011 Elsevier Inc.