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Future Market Insights delivers key insights on the global Positron Emission Tomography scanners market in a new report titled, “Positron Emission Tomography (PET) Scanners Market: Global Industry Analysis and Opportunity Assessment, 2016–2026”. In terms of revenue, the global Positron Emission Tomography (PET) scanners market is projected to register a healthy CAGR of 4.7% over the forecast period. According to Future Market Insights, growing occurrences of chronic disorders and increasing penetration of PET machines is expected to drive overall growth of the global Positron Emission Tomography (PET) scanners market during the forecast period. Rising demand for effective diagnostic techniques across the globe and expanded applications for PET in the field of oncology are further expected to boost the growth of the global Positron Emission Tomography (PET) scanners market between 2016 and 2026. However, a short half-life and low supply of radiopharmaceuticals is likely to restrict market growth over the forecast period. “A key trend in the global Positron Emission Tomography (PET) scanners market is the development of dual modality PET/CT and PET/MRI machines leading to better diagnostic sensitivity and specificity at each stage of disease prognosis. The entry of new radiopharmaceuticals has enhanced the diagnostic value of diseases treatment resulting in greater dependency on PET scanning procedures. These trends are likely to govern the global Positron Emission Tomography (PET) scanners market in the coming years.” - Analyst - Healthcare, Pharmaceuticals & Medical Devices, Future Market Insights The global Positron Emission Tomography (PET) scanners market has been segmented by Product Type (Full Ring PET Scanners, Partial Ring PET Scanners); by Application (Oncology, Cardiology, Neurology, Others); by Detector Type (Bismuth Germanium Oxide (BGO), Lutetium Oxyorthosilicate (LSO), Gadolinium Oxyorthosilicate (GSO), Lutetium Fine Silicate (LFS), Lutetium Yttrium Orthosilicate); and by End User (Hospitals, Diagnostic Centres, PET Centres, Research Institutes); The Full Ring PET Scanners product type segment was valued at US$ 759.3 Mn in 2015 and is expected to register 4.8% CAGR over the forecast period. The Partial Ring PET Scanners product type segment was valued at US$ 143.8 Mn in 2015 and is expected to increase to US$ 212.2 Mn by the end of 2026 The Oncology application segment is estimated to account for 86.6% market share by 2016 while the Cardiology application segment is estimated to account for 5.0% market share by 2016 end. Both these segments are expected to be the most lucrative segments in the global Positron Emission Tomography (PET) scanners market during the forecast period The Lutetium Oxyorthosilicate (LSO) detector type segment was valued at US$ 322.7 Mn in 2015 and is expected to witness a CAGR of 4.3% over the forecast period to reach US$ 596.5 Mn by 2026 end. The Bismuth Germanium Oxide (BGO) detector type segment was valued at US$ 266.7 Mn in 2015 and is expected to increase to US$ 400.5 Mn by the end of 2026 The Hospitals end user segment is estimated to hold 35.7% market share by 2016 end while the Diagnostic Centres end user segment is estimated to account for 33.0% market share by 2016 end The global Positron Emission Tomography (PET) scanners market has been segmented into the seven key regions of North America, Latin America, Western Europe, Eastern Europe, APEJ, MEA, and Japan. North America dominated the global Positron Emission Tomography (PET) scanners market in 2015 and is likely to continue its dominance throughout the forecast period. North America is expected to reach a market valuation of US$ 631.9 Mn by 2026 end, witnessing a CAGR of 4.8% over the forecast period. The APEJ Positron Emission Tomography (PET) scanners market is estimated to be valued at US$ 132.9 Mn by 2016 end and is expected to register a CAGR of 5.1% over the forecast period. General Electric Co., Toshiba Corporation, Koninklijke Philips N.V., Siemens AG, Hitachi, Ltd., Positron Corporation, Mediso Ltd., and Yangzhou Kindsway Biotech Co. Ltd. are some of the leading players operating in the global Positron Emission Tomography (PET) scanners market. Major players in the global Positron Emission Tomography (PET) scanners market are focussing on enhancing their global and regional presence through introduction of novel products and strategic operational expansion. The report discusses individual strategies followed by these companies in terms of enhancing product designing, creating new manufacturing facilities, market consolidation, and advanced R&D initiatives.


News Article | November 1, 2016
Site: marketersmedia.com

— The report "Small Animal Imaging (In-Vivo) Market by Modality (Optical Imaging, PET, SPECT, CT, MRI, ultrasound, Photoacoustic Imaging, Magnetic Particle Imaging), Reagent (Optical Imaging Reagents, Contrast Agents, PET Tracers, SPECT Probes) - Global forecast 2021", analyzes and studies the major market drivers, restraints, opportunities, and challenges in North America, Europe, Asia-Pacific, and the Rest of the world (RoW). Browse 83 market data Tables and 39 Figures spread through 161 Pages and in-depth TOC on "Small Animal Imaging (In-Vivo) Market " http://www.marketsandmarkets.com/Market-Reports/small-animal-imaging-market-957.html Early buyers will receive 10% customization on reports. On the basis of products, the global small animal imaging market is divided into two major categories, namely, modalities and reagents. Small animal imaging systems market is further divided into seven segments, namely, optical imaging systems, nuclear imaging systems, MRI systems, ultrasound systems, CT systems, photo-acoustic imaging systems, and magnetic particle imaging systems. Small animal imaging systems segment is estimated to command the larger share in the global small animal imaging market in 2016. The larger market share of modalities segment can primarily be attributed to the extensive & growing application of molecular imaging during preclinical researches, high cost of imaging systems, and development & commercialization of technologically advanced preclinical imaging systems. A number of factors such as the technological advancements in the field of molecular imaging, increasing market demand for non-invasive small animal imaging techniques, and growing number of public-private initiatives to support preclinical researches are propelling the growth of small animal imaging market. As of 2016, North America is expected to dominate global small animal imaging market, followed by Europe. However, the Asia-Pacific region is projected to be the fastest growing region with a double-digit CAGR during 2016-2021. A number of factors including continuous government support for pharmaceutical and biotechnology R&D, increasing public-private investments to support radioisotope production, rising number of translational research activities, and evolving regulatory scenario across major Asian countries are stimulating the growth of the small animal imaging market in the Asia-Pacific region. As of 2015, PerkinElmer, Inc. (U.S.), Bruker Corporation (U.S.), FUJIFILM Holdings Corporation (Japan), Mediso Ltd. (Hungary), MILabs B.V. (Netherlands), MR Solutions Ltd. (U.K.), Aspect Imaging (Israel), LI-COR Biosciences (U.S.), Trifoil Imaging (U.S.) and Miltenyi Biotec GmbH (Germany) are key players operating in the global small animal imaging market. For more information, please visit http://www.marketsandmarkets.com/requestsample.asp?id=957


News Article | December 6, 2016
Site: www.newsmaker.com.au

According to Stratistics MRC, the Global Nuclear Medicine Market is valued at $4.42 billion in 2015 and is expected to grow at a CAGR of 10.55 % to reach $8.92 billion by 2022. Rising demand from emerging nations and the growing incidence of cardiovascular ailments and cancers are some of the key factors driving the market growth. Conversely, strict government regulations and competition from conventional diagnostic methods are hampering the market. Furthermore, technological advancements in neurological applications are anticipated to create ample of opportunities for the market in the future. North America is the largest market in terms of revenue in 2015 due to several technological advancements within the region. However, Asia Pacific is poised to grow at a faster pace due to the increasing incidence of neurological and cardiovascular diseases and cancer. Various new products are being launched together with the several technological advancements. Thus, new product launch is the key strategy followed by the players to gain the traction in the market. Some of the key players in global Nuclear Medicine market are Advanced Accelerator Applications S.A., Ashby Gorman Baker Ltd, Bayer Healthcare, Bracco Imaging S.P.A, Cardinal Health, Digirad, Eczcibasi-Monrol Nuclear Products, GE Healthcare, IBA Molecular Imaging, Lantheus Medical Imaging, Mallinckrodt PLC, Mediso Ltd., Nordion, Inc., Philips Healthcare and Siemens Healthcare. Regions Covered: • North America o US o Canada o Mexico • Europe o Germany o France o Italy o UK  o Spain      o Rest of Europe  • Asia Pacific o Japan        o China        o India        o Australia        o New Zealand       o Rest of Asia Pacific       • Rest of the World o Middle East o Brazil o Argentina o South Africa o Egypt What our report offers: - Market share assessments for the regional and country level segments - Market share analysis of the top industry players - Strategic recommendations for the new entrants - Market forecasts for a minimum of 7 years of all the mentioned segments, sub segments and the regional markets - Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations) - Strategic recommendations in key business segments based on the market estimations - Competitive landscaping mapping the key common trends - Company profiling with detailed strategies, financials, and recent developments - Supply chain trends mapping the latest technological advancements


Steinbach C.O.,Budapest University of Technology and Economics | Szlavecz A.,Budapest University of Technology and Economics | Benyo B.,Budapest University of Technology and Economics | Bukki T.,Mediso Ltd. | Lorincz E.,Budapest University of Technology and Economics
IEEE Transactions on Nuclear Science | Year: 2010

A new Monte Carlo simulation tool, called PetDetSim and its experimental validation is presented. The simulation environment aims to model PET detectors and applies the Detect2000 code. Light output of LYSO and GSO crystal pins of different size and surface finish, covered with diffuse or specular reflectors was experimentally determined and compared with the results of the simulations. By improving the model concerning the pin and reflector geometry and the wavelength dependent reflection of the photocathode, the figure of merit could be considerably improved. The initially 34% deviation between simulation and measurements decreased below 11% for all LYSO crystal configurations. © 2010 IEEE.


Lorincz E.,Budapest University of Technology and Economics | Erdei G.,Budapest University of Technology and Economics | Peczeli I.,Budapest University of Technology and Economics | Steinbach C.,Budapest University of Technology and Economics | And 2 more authors.
IEEE Transactions on Nuclear Science | Year: 2010

A new Zemax model has been developed, which reliably predicts the light output of scintillator crystal pins for Positron Emission Tomography. Different configurations, including pin shape, surface finish and reflector types are investigated. The simulations use the actual measured wavelength-dependent parameters of the scintillator crystal, of the reflector and of the PMT's components. Good agreement is demonstrated between simulated and measured light output figures for 33 different pin configurations. The highest light output was found by both simulation and experiment for the pins with polished superficies (either polished or diffuse γ-side) with a non-coupled high reflectivity specular reflector around the superficies and an optically coupled high reflectivity diffuse reflector on the γ-side. We also present the measured light output homogeneity of a scintillator array fabricated according to one of the best pin configurations. © 2010 IEEE.


Szirmay-Kalos L.,Budapest University of Technology and Economics | Toth B.,Budapest University of Technology and Economics | Jakab G.,Mediso Ltd.
2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 | Year: 2014

Positron Emission Tomography reconstruction is ill posed. The result obtained with the iterative ML-EM algorithm is often noisy, which can be controlled by regularization. Common regularization methods penalize high frequency features or the total variation, thus they compromise even valid solutions that have such properties. Bregman iteration offers a better choice enforcing regularization only where needed by the noisy data. Bregman iteration requires a nested optimization, which poses problems when the algorithm is implemented on the GPU where storage space is limited and data transfer is slow. Another problem is that the strength of the regularization is set by a single global parameter, which results in overregularization for voxels measured by fewer LORs. To handle these problems, we propose a modified scheme that merges the two optimization steps into one, eliminating the overhead of Bregman iteration. The algorithm is demonstrated for a 2D test scenario and also in fully 3D reconstruction. The benefits over TV regularization are particularly high if the data has higher variation and point like features. The proposed algorithm is built into the TeraTomo™ system. © 2014 IEEE.


Szlavecz A.,Budapest University of Technology and Economics | Bukki T.,Mediso Ltd. | Steinbach C.,Budapest University of Technology and Economics | Benyo B.,Budapest University of Technology and Economics
Biomedical Signal Processing and Control | Year: 2011

Abstract: In this paper we present the development of a modelling convention and a modelling environment, called PetDetSim, able to describe different PET detector block geometries. Using the developed simulation environment, the PET detector block designer can easily define different detector block configurations and test their optical behaviour regarding the characteristic features that determine the imaging quality of the device. In addition to the common optical behaviour of the detector block the developed modelling environment is also able to model gamma photon penetration. The PetDetSim environment is designed to use on a computer cluster and in a grid computing environment in order to reduce the computation time of the simulation. The validation of PetDetSim has been successfully done in the case of basic detector models, i.e. consisting of a single crystal needle. © 2010 Published by Elsevier Ltd. All rights reserved.


Szlavecz A.,Budapest University of Technology and Economics | Hesz G.,Budapest University of Technology and Economics | Bukki T.,Mediso Ltd. | Kari B.,Semmelweis University | Benyo B.,Budapest University of Technology and Economics
IFAC Proceedings Volumes (IFAC-PapersOnline) | Year: 2011

Parallel projection based Single Photon Emission Computed Tomography (SPECT) is one of the most widely used nuclear imaging technique even nowadays. Serious artefacts are produced in the reconstructed images due to the non-homogeneous attenuation medium and the distance dependent spatial resolution (DDSR) of the parallel imaging. Effective non-uniform attenuation correction and DDSR reduction procedures should be applied in order to improve the SPECT image quality. We have developed a novel parallel reconstruction method using the Maximum Likelihood Expectation Maximization iterative reconstruction algorithm with attenuation correction and compensation for the DDSR effect in the forward projector. In order to compensate the well-known extreme computation intensity of this reconstruction method a parallel version of the algorithm is created where the computation tasks of the algorithm are executed simultaneously on a GPU. By this reduction of the running time this accurate reconstruction algorithm become available for the use in the clinical applications. The algorithm has been verified using simulation studies. © 2011 IFAC.


Szirmay-Kalos L.,Budapest University of Technology and Economics | Magdics M.,Budapest University of Technology and Economics | Toth B.,Budapest University of Technology and Economics | Bukki T.,Mediso Ltd.
IEEE Transactions on Medical Imaging | Year: 2013

Iterative positron emission tomography (PET) reconstruction computes projections between the voxel space and the lines of response (LOR) space, which are mathematically equivalent to the evaluation of multi-dimensional integrals. The dimension of the integration domain can be very high if scattering needs to be compensated. Monte Carlo (MC) quadrature is a straightforward method to approximate high-dimensional integrals. As the numbers of voxels and LORs can be in the order of hundred millions and the projection also depends on the measured object, the quadratures cannot be precomputed, but Monte Carlo simulation should take place on-the-fly during the iterative reconstruction process. This paper presents modifications of the maximum likelihood, expectation maximization (ML-EM) iteration scheme to reduce the reconstruction error due to the on-the-fly MC approximations of forward and back projections. If the MC sample locations are the same in every iteration step of the ML-EM scheme, then the approximation error will lead to a modified reconstruction result. However, when random estimates are statistically independent in different iteration steps, then the iteration may either diverge or fluctuate around the solution. Our goal is to increase the accuracy and the stability of the iterative solution while keeping the number of random samples and therefore the reconstruction time low. We first analyze the error behavior of ML-EM iteration with on-the-fly MC projections, then propose two solutions: averaging iteration and Metropolis iteration. Averaging iteration averages forward projection estimates during the iteration sequence. Metropolis iteration rejects those forward projection estimates that would compromise the reconstruction and also guarantees the unbiasedness of the tracer density estimate. We demonstrate that these techniques allow a significant reduction of the required number of samples and thus the reconstruction time. The proposed methods are built into the Teratomo system. © 1982-2012 IEEE.


PubMed | University of Kiel, Mediso Ltd. and Medical University of Vienna
Type: Evaluation Studies | Journal: Cancer imaging : the official publication of the International Cancer Imaging Society | Year: 2016

Because of the increasing importance of computer-assisted post processing of image data in modern medical diagnostic we studied the value of an algorithm for assessment of single photon emission computed tomography/computed tomography (SPECT/CT)-data, which has been used for the first time for lymph node staging in penile cancer with non-palpable inguinal lymph nodes. In the guidelines of the relevant international expert societies, sentinel lymph node-biopsy (SLNB) is recommended as a diagnostic method of choice. The aim of this study is to evaluate the value of the afore-mentioned algorithm and in the clinical context the reliability and the associated morbidity of this procedure.Between 2008 and 2015, 25 patients with invasive penile cancer and inconspicuous inguinal lymph node status underwent SLNB after application of the radiotracer Tc-99m labelled nanocolloid. We recorded in a prospective approach the reliability and the complication rate of the procedure. In addition, we evaluated the results of an algorithm for SPECT/CT-data assessment of these patients.SLNB was carried out in 44 groins of 25 patients. In three patients, inguinal lymph node metastases were detected via SLNB. In one patient, bilateral lymph node recurrence of the groins occurred after negative SLNB. There was a false-negative rate of 4% in relation to the number of patients (1/25), resp. 4.5% in relation to the number of groins (2/44). Morbidity was 4% in relation to the number of patients (1/25), resp. 2.3% in relation to the number of groins (1/44). The results of computer-assisted assessment of SPECT/CT data for sentinel lymph node (SLN)-diagnostics demonstrated high sensitivity of 88.8% and specificity of 86.7%.SLNB is a very reliable method, associated with low morbidity. Computer-assisted assessment of SPECT/CT data of the SLN-diagnostics shows high sensitivity and specificity. While it cannot replace the assessment by medical experts, it can still provide substantial supplement and assistance.

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