Yokohama-shi, Japan
Yokohama-shi, Japan

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Patent
Medinet Co. and Futami | Date: 2015-02-04

The present invention provides the following: a method for efficiently producing a reagent for detecting an antibody that specifically binds with an insoluble antigen protein present in a liquid sample; a reagent for antibody detection produced by the production method; and a use of the antibody. In a step for solubilizing an antigen protein, it is possible to efficiently solubilize and recover the antigen protein by using a cationizing agent; therefore, when compared to conventional methods, it is possible to efficiently produce a reagent for detecting an antibody that has bound to multiple antigen protein molecules in a carrier.


A filtration instrument can be used to remove foreign matter in a cell suspension and include a filter container. The filter container uses a transparent or semi-transparent material and is constructed so that solids that have been captured by the filter can be removed easily. Specifically, the filter container is constructed so that solids that have been captured by the filter can be removed easily by cutting the filter container using scissors. This construction serves to prevent the admixture of foreign matter in the cell suspension and, should foreign matter become admixed, facilitates the explanation of the cause of the admixture of foreign matter by allowing for the ability to remove and to analyze the foreign matter.


Patent
Medinet Co. | Date: 2013-11-12

Activated antigen-presenting cells that can induce immunocytes including disease antigen-specific CD8+ CTLs and/or T cells efficiently in vivo and/or in vitro, a medical composition comprising the activated antigen-presenting cells, a treatment and prevention method using the activated antigen-presenting cells, and an induction method of immunocytes including disease antigen-specific CTLs and/or T cells induced using the activated antigen-presenting cell, immunocytes induced by the above-noted method, a medical composition comprising the immunocytes, and a treatment and prevention method using the immunocytes are provided. By co-pulsing antigen-presenting cells with bisphosphonate in addition to the pulse with a disease antigen, the ratio of disease antigen-specific CD8+ CTLs and/or T cells and the number of the disease antigen-specific CD8+ CTLs and the T cells can be increased, compared with the case where the co-pulse with bisphosphonate is not carried out.


Patent
Medinet Co. | Date: 2011-04-20

Disclosed are: a method for culture of disease antigen specific CTLs and T cells in one culture step conveniently and efficiently; and a pharmaceutical agent and a therapeutic/prophylactic method both of which use a cell produced by the method. Blood is collected and peripheral blood mononuclear cells are separated from the blood. Aminobisphosphonate and a disease antigen are added to the peripheral blood mononuclear cells at the beginning of culture, and the cell culture is carried out for a predetermined period to proliferate/induce disease antigen specific CTLs and T cells simultaneously until the numbers of the cells reach values that are effective for the treatment of a disease. The CTLs and the T cells thus produced are used for the treatment.


Patent
Medinet Co. | Date: 2014-09-02

To avoid contamination of workspaces by splashing and the like of a waste fluid. A fluid delivery system for delivering a fluid from one container to another container includes: a delivery channel connecting between the one container to the other container; and a delivery pump which feeds the fluid into the delivery channel by compressively deforming inner diameter in the middle of the delivery channel, wherein the delivery channel is a partially elastic configuration that can be compressively deformed by the delivery pump, and also is a closed-system configuration with which the fluid flowing inside thereof is isolated from outside. As described, the delivery pump and the delivery tube or the waste-fluid container are not directly connected but are simply in contact. Therefore, it is possible to prevent splashing and the like of the waste fluid onto a work space when handling the waste fluid.


Patent
Medinet Co. | Date: 2016-07-13

To avoid contamination of workspaces by splashing and the like of a waste fluid. A fluid delivery system for delivering a fluid from one container to another container includes: a delivery channel connecting between the one container to the other container; and a delivery pump which feeds the fluid into the delivery channel by compressively deforming inner diameter in the middle of the delivery channel, wherein the delivery channel is a partially elastic configuration that can be compressively deformed by the delivery pump, and also is a closed-system configuration with which the fluid flowing inside thereof is isolated from outside. As described, the delivery pump and the delivery tube or the waste-fluid container are not directly connected but are simply in contact. Therefore, it is possible to prevent splashing and the like of the waste fluid onto a workspace when handling the waste fluid.


A filtration instrument to be used to remove foreign matter in a cell suspension wherein the filter container uses a transparent or semi-transparent material and is constructed so that solids that have been captured by the filter can be removed easily. Specifically, the filter container is constructed so that solids that have been captured by the filter can be removed easily by cutting the filter container by scissors. This construction serves to prevent the admixture of foreign matter in the cell suspension and, should foreign matter become admixed, facilitates the explanation of the cause of the admixture of foreign matter by removing and analyzing the foreign matter.


A therapeutic method, which includes administering dendritic cells pulsed in vitro with a bisphosphonate-based bone metabolism improving drug, is provided. The dendritic cells may be capable of efficiently activating and/or proliferating T-cells in vivo and/or in vitro. This can permit for easy proliferation of T-cells without burdening a patient, leading to practical applications of immune cell therapies that utilize T-cells.


Patent
Medinet. Co. | Date: 2010-12-22

The present invention provides a monoclonal antibody against FLJ32028, which binds specifically to the surfaces of regulatory T-cells (Treg) and especially to the surfaces of induced Treg. This monoclonal antibody can be used for a Treg-removal method or a Treg-removal apparatus. This monoclonal antibody can also be used as a drug that improves cell-proliferation function, an immune-enhancement function, or especially for cancer treatment.


The present invention provides the following: a method for efficiently producing a reagent for detecting an antibody that specifically binds with an insoluble antigen protein present in a liquid sample; a reagent for antibody detection produced by the production method; and a use of the antibody. In a step for solubilizing an antigen protein, it is possible to efficiently solubilize and recover the antigen protein by using a cationizing agent; therefore, when compared to conventional methods, it is possible to efficiently produce a reagent for detecting an antibody that has bound to multiple antigen protein molecules in a carrier.

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