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Srinivasulu K.,Mediciti Institute of Medical science
Indian Journal of Forensic Medicine and Toxicology | Year: 2014

The study on assessment of Medical certification of cause of death was conducted at a rural medical college hospital in Andhra Pradesh to find out the errors in cause of death certificates for a period of one year from 1st January 2011 to 31st December 2011. The certificates are collected from Medical record department of the hospital along with case sheets and analysed for errors. The errors are grouped in to two Major and Minor, Not even a single certificate is free from error, majority of the errors an average about 47% are found in Major group and minor group consist 21% of errors, Most of the errors are avoidable with proper guidance and periodical training to the medical practitioners. © 2014, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

Srinivasulu K.,Mediciti Institute of Medical science
Medico-Legal Update | Year: 2013

Prescription is one of the important Medico legal documents, the art of prescription writing has an ancient inheritance, commonly the prescription considered as a written order by the physician to the pharmacist to prepare and dispense the drugs. The term prescription means an order to take certain medications. Prescriptions have legal implications, prescriber is responsible for clinical care of the patient. Doctors are facing charges of medical negligence due to wrong prescriptions and illegible prescriptions, the number of cases filed in the courts are increasing day by day since from the inception of Consumer protection act in medical practise. A cross sectional study was done with an objective to appraise the importance and various medico legal aspects in prescription writing. The study was conducted at Ranga reddy Dist area in duration of one year, prescriptions were collected randomly from the patients and analysed for errors and deficiencies, in my study I observed too many lacunas in the prescriptions which can lead to medico legal problems.

Ganguly E.,Mediciti Institute of Medical science
Online Journal of Health and Allied Sciences | Year: 2012

Reducing Total Fertility Rate (TFR) amongst rural Indian couples from the current level is a significant challenge to the population control policies relying solely on the Government efforts. REACH strategy, based on health metrics, succeeded in lowering the TFR below replacement levels in a rural population of more than 300,000 in Rajasthan. The REACH strategy was first developed and demonstrated success in decreasing TFR in a pilot project by SHARE India in Medchal region of Andhra Pradesh utilizing designated workers, and was replicated in Rajgarh District of Rajasthan in cooperation with Bhoruka Charitable Trust (supervisor of ICDS and NRHM health workers in Rajgarh) using Government health workers. The success of the REACH strategy in both Rajasthan and previously in Andhra Pradesh holds promise as a tool to reduce TFR in other areas of rural India.

Rekha C.,Mediciti Institute of Medical science
Indian journal of public health | Year: 2013

Accurate reporting of prevalence of low birth weight (LBW) is important for monitoring health of a population. LBW is often underestimated in developing countries due to heaping of the data at 2.5 kg. UNICEF uses an average adjustment factor of 25% to re-classify babies listed as exactly 2.5 kg into the LBW category. From October 2009 to February 2010, we weighed 859 consecutive live births at a rural hospital in Andhra Pradesh, India, using analog and digital scales to evaluate the relative validity of the adjustment factor. Significantly more babies weighed exactly 2.5 kg on analog (13.4%) versus digital (2.2%) scales, showing heaping. Percentage of LBW by digital method (29.5%) was significantly higher compared to the analog method (23%) and with adjustment factors (26.4%). Conventional methods of adjusting birth-weight data underestimate the prevalence of LBW. Sensitive digital weighing machines or better adjustment methods are needed to monitor LBW in developing countries.

Kulkarni A.K.,Mediciti Institute of Medical science | Ojha R.P.,University of Gorakhpur
Journal of Biomolecular Structure and Dynamics | Year: 2015

Solution conformation of the cyclic hexapeptide sequence, [cyclo-S-Cys-Tyr-Ile-Gln-Asn-Cys-S] (CYIQNC) - a disulfide-linked fragment of a neurohypophyseal peptide hormone oxytocin (OT) - has been investigated by high-field one-dimensional (1D) and two-dimensional (2D) NMR spectroscopic methods and compared with the results obtained from computer simulation studies. 1H-NMR results based on temperature dependence of amide proton chemical shifts and nuclear Overhauser effect indicate that peptide in solution populates different conformations, characterized by two fused β-turns. The segment Ile3-Gln4-Asn5-Cys6 yields a preferred type-III β-turn at residues 4, 5 (HB, 3HN → 6CO), while the segment Cys6, Cys1-Tyr2-Ile3 exhibits inherently weaker, flexible β-turn either of type I/II'/III/half-turn at residues 1, 2 (HB, 6HN → 3CO). The computer simulation studies using a mixed protocol of distance geometry-simulated annealing followed by constrained minimization, restrained molecular dynamics, and energy minimization showed the possibility of existence of additional conformations with the hydrogen bonds, (a) 5HN → 3CO and (b) 2HN → 6CO. These results, therefore, indicate that the additional conformations obtained from both NMR and simulation studies can also be possible to the peptide. These additional conformations might have very small population in the solution and did not show their signatures in these conditions. These findings will be helpful in designing more analogs with modifications in the cyclic moiety of OT. © 2014 Taylor & Francis.

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