Duran N.E.,Kartal Kosuyolu Heart and Research Hospital Cardiology |
Oguz E.,Kartal Kosuyolu Heart and Research Hospital Cardiology |
Duran I.,Medicana Camlica Hospital Cardiology |
Aykan A.C.,Kartal Kosuyolu Heart and Research Hospital Cardiology |
And 7 more authors.
Phlebology | Year: 2010
Objectives: The relationship between venous thrombosis (VT) and atherosclerosis is controversial in recent studies. Aortic elastic properties have a predictive value in detecting early stages of atherosclerosis. The aim of this study is to evaluate the relationship between aortic elastic properties and VT. Methods: Elastic properties of aorta in patients with spontaneous VT, without history of known cardiovascular disease and cardiovascular risk factors (n: 31), and in healthy subjects without cardiovascular risk factors (n: 30) were compared. Elastic properties of the aorta were assessed with transthoracic echocardiography. Results: A significant increase in aortic stiffness index (6.5±1.0 versus 6±0.7, P = 0.03) and a significant decrease in aortic strain and aortic distensibility were found in patients with VT compared with healthy subjects (8.4±7 versus 13±8, P = 0.01, 4.9±4.8 versus 6.5±l4.4, P = 0.03, respectively). Conclusions: Elastic properties of aorta in patients with spontaneous VT were impaired. These results may support the role of endothelial dysfunction in the pathogenesis of VT.