Gaziantep, Turkey
Gaziantep, Turkey

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PubMed | Medicalpark Hospital, Hacettepe University, Oncology Teaching and Research Hospital, Gazi University and 2 more.
Type: Journal Article | Journal: Journal of laboratory automation | Year: 2016

The aim of the present study was to determine the relation between the simultaneous fasting plasma glucose level and HbA1c in a large population of patients presenting to the hospital, based on various measurement methods available for HbA1c. HbA1c levels of 162,210 patients presenting to various hospitals and laboratories were measured based on seven different systems, and at the same time, eAG levels were calculated based on HbA1c levels. The correlation coefficients (r) between serum plasma glucose and HbA1c levels were found to be 0.809, 0.774, 0.779, 0.817, 0.704, 0.796, and 0.747 in Bio-Rad Variant II, Tosoh G8, ADAMS A1c, Trinity Boronate Affinity, Chromsystems HPLC, Roche Tina-quant, and Abbott Architect, respectively. The concordance correlation coefficients between the eAG levels as calculated with the formulas provided in the text and the eAG levels as calculated according to NGSP directions (where eAG = (28.7*HbA1c) - 46.7) were found to be between 0.9339 and 0.9866. Despite the progress made for the standardization of HbA1c measurements, the relation between serum glucose and HbA1c still demonstrated certain discrepancies pertaining to the differences in measurement methodologies. As a conclusion, each laboratory could determine different eAG levels depending on the data originated by their individual analyzer.


Cavusoglu T.,Ege University | Erbas O.,Gaziosmanpaşa University | Karadeniz T.,Izmir Tepecik Training and Research Hospital | Akdemir O.,Medicalpark Hospital | And 4 more authors.
Experimental and Clinical Endocrinology and Diabetes | Year: 2014

Background: One of the major concerns is a nephropathy in diabetes, which applies many different kinds of medicines. However, required level of the treatment of renal disease has not been achieved. Aim: To investigate and compare the effect of the enalapril and the exenatide on diabetic nephropathy in rats developed diabetes by streptozosin. Material and Methods: 32 male Sprague Dawley rats were divided into 4 groups: (1) Control, (2) Diabetic (DM), (3) DM+ Enalapril, and (4) DM+ exenatide groups. Then, the animals were euthanized and their blood samples were collected by cardiac puncture for blood glucose; blood urea nitrogen (BUN), creatinin, and nephrectomy were performed for histopathologic examination, and urine samples were taken on stick for proteinuria. Results: Administration of the enalapril or the exenatide in diabetic rats resulted in a significant reduction both fibronectin, induced nitric oxide synthase (i-NOS) expression in glomerular area and urine protein levels. It was shown that both of enalapril and exenatide protected the renal glomerulus more than diabetic group in the nephropathy histopathologically. Conclusion: The beneficial effects of enalapril and exenatide which reduces fibronectin, i-NOS expression and urine protein levels or increases recovery of glomerules, might be used for preventing the harmful effects of diabetic nephropathy. © 2014 Georg Thieme Verlag KG Stuttgart New York.


PubMed | Medicalpark Hospital, Gaziosmanpaşa University, Izmir University, Celal Bayar University and 2 more.
Type: Comparative Study | Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association | Year: 2014

One of the major concerns is a nephropathy in diabetes, which applies many different kinds of medicines. However, required level of the treatment of renal disease has not been achieved.To investigate and compare the effect of the enalapril and the exenatide on diabetic nephropathy in rats developed diabetes by streptozosin.32 male Sprague Dawley rats were divided into 4 groups: (1) Control, (2) Diabetic (DM), (3) DM+ Enalapril, and (4) DM+ exenatide groups. Then, the animals were euthanized and their blood samples were collected by cardiac puncture for blood glucose; blood urea nitrogen (BUN), creatinin, and nephrectomy were performed for histopathologic examination, and urine samples were taken on stick for proteinuria.Administration of the enalapril or the exenatide in diabetic rats resulted in a significant reduction both fibronectin, induced nitric oxide synthase (i-NOS) expression in glomerular area and urine protein levels. It was shown that both of enalapril and exenatide protected the renal glomerulus more than diabetic group in the nephropathy histopathologically.The beneficial effects of enalapril and exenatide which reduces fibronectin, i-NOS expression and urine protein levels or increases recovery of glomerules, might be used for preventing the harmful effects of diabetic nephropathy.


PubMed | Medicalpark Hospital, Turkish Advanced Specialty Training and Research Hospital, Koru Hospital, Umraniye Trianing and Research Hospital and 2 more.
Type: Journal Article | Journal: Northern clinics of Istanbul | Year: 2017

Bile leakage, while rare, can be a complication seen after cholecystectomy. It may also occur after hepatic or biliary surgical procedures. Etiology may be underlying pathology or surgical complication. Endoscopic retrograde cholangiopancreatography (ERCP) can play major role in diagnosis and treatment of bile leakage. Present study was a retrospective analysis of outcomes of ERCP procedure in patients with bile leakage.Patients who underwent ERCP for bile leakage after surgery between 2008 and 2012 were included in the study. Etiology, clinical and radiological characteristics, and endoscopic treatment outcomes were recorded and analyzed.Total of 31 patients (10 male, 21 female) were included in the study. ERCP was performed for bile leakage after cholecystectomy in 20 patients, after hydatid cyst operation in 10 patients, and after hepatic resection in 1 patient. Clinical signs and symptoms of bile leakage included abdominal pain, bile drainage from percutaneous drain, peritonitis, jaundice, and bilioma. Twelve (60%) patients were treated with endoscopic sphincterotomy (ES) and nasobiliary drainage (NBD) catheter, 7 patients (35%) were treated with ES and biliary stent (BS), and 1 patient (5%) was treated with ES alone. Treatment efficiency was 100% in bile leakage cases after cholecystectomy. Ten (32%) cases of hydatid cyst surgery had subsequent cystobiliary fistula. Of these patients, 7 were treated with ES and NBD, 2 were treated with ES and BS, and 1 patient (8%) with ES alone. Treatment was successful in 90% of these cases.ERCP is an effective method to diagnose and treat bile leakage. Endoscopic treatment of postoperative bile leakage should be individualized based on etiological and other factors, such as accompanying fistula.


Yilmaz M.,Bursa Ihtisas Training and Research Hospital | Arican Ozluk F.O.,Bursa Ihtisas Training and Research Hospital | Akgumus A.,Bursa Ihtisas Training and Research Hospital | Peker T.,Bursa Ihtisas Training and Research Hospital | And 3 more authors.
Acta Cardiologica | Year: 2013

Objective Metabolic syndrome (MS) is a cluster of risk factors leading to cardiometabolic diseases. The aim of the present study was to investigate the eff ect of MS on left atrial function, which is an important determinant of left ventricular filling. Methods Left atrial (LA) volumes were measured echocardiographically in 32 MS patients and 32 age- and sex-matched controls. LA volumes were determined at the time of mitral valve opening (maximal, Vmax), at the onset of atrial systole (p wave on the electrocardiogram, Vp) and at the mitral valve closure (minimal, Vmin) according to the biplane area-length method in apical 4-chamber and 2-chamber view. All volumes were corrected to the body surface area, and following left atrial emptying functions were calculated. LA passive emptying volume = Vmax - Vp, LA passive emptying fraction = LA passive emptying volume/Vmax. Conduit volume = LV stroke volume - (Vmax - Vmin), LA active emptying volume = Vp - Vmin, LA active emptying fraction = LA active emptying volume/Vp, LA total emptying volume = (Vmax -Vmin), LA total emptying fraction = LA total emptying volume/Vmax. Results LA maximal volume and LA presystolic volume were significantly higher in MS patients than in controls (P < 0.001). But LA minimum volume was significantly lower in MS patients than in controls (P < 0.001). Although LA passive emptying volume (P < 0.03), LA passive emptying fraction (P < 0.001) and conduit volume (P < 0.001) were found to be significantly lower in MS patients than in controls, LA active emptying volume (P < 0.001) and LA active emptying fraction (P < 0.001) were significantly greater in MS patients than in controls. Conclusion In our study, metabolic syndrome was associated with increased left atrial volume, decreased left atrial passive emptying function and increased pump function. Increased left atrial pump function represents a compensatory mechanism in patients with MS. Thus, these results underline the importance of maintaining a sinus rhythm in these patients.


Ozkaya S.,Recep Tayyip Erdoğan University | Findik S.,Ondokuz Mayis University | Atici A.G.,Ondokuz Mayis University | Dirican A.,Medicalpark Hospital
Neoplasma | Year: 2011

Lung cancer continues to be the leading cause of cancer-related mortality and approximately 70% of patients present with locally advanced or metastatic disease at the time of diagnosis. More than 50% of lung cancer cases are diagnosed in patients over the age of 65 years. The doublet chemotherapies consisting of platinum plus one of the third-generation agents become currently the standard regimen, the first line chemotherapy The most of the available data regarding the optimal treatment of lung cancer comes from clinical trials in which the vast majority of patients are significantly younger than 65 years of age. We aimed to investigate whether there is any difference in tolerability and efficacy in between adult(<65 years old) and elderly(≥65 years old) patients who received cisplatin based chemoteherapy or chemoradiotherapy for stage IIIB and IV non-small cell lun cancer. We retrospectively evaluated the total 134 patients with advanced stage (stage IIIB or IV) NSCLC, in Ondokuzmayi{dotless}s University, Faculty of Medicine, Department of Pulmonary Medicine between 2001 and 2004. The response rates were 30.3% in adults and 28.8% in elderly patients. The median survival was 13.6±1.4 months and 11.8±2.0 months for adults and elderly patients, respectively. The one-year, two year and five year survival rates were 37%, 9%, 4% for adult patients and 29%, 7%, 4% for elderly patients, respectively. There was no statistical difference between the groups. Percentages of grade 3-4 anemia (0% vs 6.6%) and grade 3-4 neutropenia (0% vs 4.4%) were higher in elderly patients than adult patients. Other toxic effects were similar among both of groups. In conclussion; standart cisplatin containing chemotherapy regimens (cisplatin plus gemcitabine or vinorelbine) can be used in elderly patients with advanced non-small cell lung cancer.


PubMed | Medicalpark Hospital, Ortadogu Hospital, Yuksek Ihtisas Education and Research Center and Bahcesehir University
Type: Journal Article | Journal: Arquivos brasileiros de cardiologia | Year: 2016

Atrial fibrillation (AF) is the most common arrhythmia seen in adults. Atrial stunning is defined as the temporary mechanical dysfunction of the atrial appendage developing after AF has returned to sinus rhythm (SR).We aimed to evaluate atrial contractile functions by strain and strain rate in patients with AF, following pharmacological and electrical cardioversion and to compare it with conventional methods.This study included 41 patients with persistent AF and 35 age-matched control cases with SR. All the AF patients included in the study had transthoracic and transesophageal echocardiography performed before and after. Septum (SEPsSR), left atrium (LAsSR) and right atrium peak systolic strain rate (RAsSR) were defined as the maximum negative value during atrial contraction and septum (SEP), left atrium (LA) and right atrium peak systolic strain (RA) was defined as the percentage of change. Parameters of two groups were compared.In the AF group, 1st hour and 24th hour LA, RA, SEP, LAsSR, RAsSR, SEPsSR found to be significantly lower than in the control group (LA: 2.61%0.13, 3.06%0.19 vs 6.45%0.27, p<0.0001; RA: 4.03%0.38, 4.50%0.47 vs 10.12%0.64, p<0.0001; SEP: 3.0%0.22, 3.19%0.15 vs 6.23%0.49, p<0.0001; LAsSR: 0.610.04s-1, 0.750.04s- 1 vs 1.350.04s-1, p<0.0001; RAsSR: 1.130.06s-1, 1.230.07s-1 vs 2.100.08s- 1, p<0.0001; SEPsSR: 0.760.04s- 1, 0.780.04s- 1 vs 1.420.06 s- 1, p<0.0001).Atrial strain and strain rate parameters are superior to conventional echocardiographic parameters for the evaluation of atrial stunning in AF cases where SR has been achieved.


Kalkan G.,Gaziosmanpaşa University | Yigit S.,Gaziosmanpaşa University | Karakus N.,Gaziosmanpaşa University | Bas Y.,Gaziosmanpaşa University | And 2 more authors.
Journal of Dermatology | Year: 2013

Recurrent aphthous stomatitis (RAS) has a multifactorial etiopathogenesis, an interaction between predisposing factors and/or systemic conditions and immunological components in genetically predisposed subjects. The Mediterranean fever (MEFV) gene has already been identified as being responsible for familial Mediterranean fever. Because the association between MEFV gene mutations and Behçet's disease has been reported before in several studies, we considered that the role of MEFV gene mutations should be studied in patients with RAS, because of the clinical similarities of both diseases. The aim of this study was to explore the frequency and clinical significance of MEFV gene mutations in a cohort of Turkish patients with RAS. The study population comprised 100 unrelated patients with a clinical diagnosis of RAS and 156 healthy controls. Genomic DNA was isolated and genotyped using polymerase chain reaction and restriction fragment length polymorphism for the four MEFV gene mutations (M694V, M680I, V726A and E148Q). There were statistically significant differences of the MEFV gene mutation carrier rates and allele frequencies between RAS patients and healthy controls (P = 0.042, odds ratio [OR] = 1.9, 95% confidence interval [CI] = 1.01-3.41; and P = 0.039, OR = 1.8, 95% CI = 1.02-3.14, respectively). Even if it is not statistically significant, the E148Q allele frequency was higher in patients with RAS than the control group. A statistically significant increased prevalence of MEFV variants in RAS patients was found. This is the first study to report that missense mutations of MEFV is associated with RAS in the Turkish population. © 2013 Japanese Dermatological Association.


Willbold E.,Hannover Medical School | Kaya A.A.,Muǧla University | Kaya R.A.,MedicalPark Hospital | Beckmann F.,Helmholtz Center Geesthacht | Witte F.,Hannover Medical School
Materials Science and Engineering B: Solid-State Materials for Advanced Technology | Year: 2011

The corrosion of biodegradable materials is a crucial issue in implant development. Among other materials, magnesium and magnesium based alloys are one of the most promising candidates. Since the corrosion of biodegradable materials depends on different physiological parameters like pH or ion concentrations, the corrosion might be different in different biological environments. To investigate this issue, we produced screws from magnesium alloy AZ31 and implanted them into the hip bone of 14 sheep. After 3 and 6 months, the screws were explanted and analyzed with synchrotron-radiation based micro-computed tomography and hard tissue histology. We found considerable differences in the corrosion behavior of the magnesium screws with respect to its original tissue location. However, we could detect a normal immunological tissue response. © 2011 Elsevier B.V. All rights reserved.


PubMed | Medicalpark Hospital
Type: Case Reports | Journal: The Annals of thoracic surgery | Year: 2014

Congenital mitral valve regurgitation is a rare disease that is found in infancy and childhood, and sometimes in elderly people. In the case presented, mitral regurgitation that was tolerated well until the sixth decade of life is reported. A 62-year-old male suffering from dyspnea was referred to our hospital. Transthoracic echocardiographic examination demonstrated severe mitral regurgitation with suspicion of agenesis of the posterior leaflet with a long, mobile anterior leaflet. A transesophageal echocardiogram and surgical evaluation verified agenesis of the posterior mitral valve. The patient was successfully treated using mitral valve replacement, and no complications occurred.

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