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Gaziantep, Turkey

Ozkaya S.,Recep Tayyip Erdogan University | Findik S.,Ondokuz Mayis University | Atici A.G.,Ondokuz Mayis University | Dirican A.,Medicalpark Hospital
Neoplasma | Year: 2011

Lung cancer continues to be the leading cause of cancer-related mortality and approximately 70% of patients present with locally advanced or metastatic disease at the time of diagnosis. More than 50% of lung cancer cases are diagnosed in patients over the age of 65 years. The doublet chemotherapies consisting of platinum plus one of the third-generation agents become currently the standard regimen, the first line chemotherapy The most of the available data regarding the optimal treatment of lung cancer comes from clinical trials in which the vast majority of patients are significantly younger than 65 years of age. We aimed to investigate whether there is any difference in tolerability and efficacy in between adult(<65 years old) and elderly(≥65 years old) patients who received cisplatin based chemoteherapy or chemoradiotherapy for stage IIIB and IV non-small cell lun cancer. We retrospectively evaluated the total 134 patients with advanced stage (stage IIIB or IV) NSCLC, in Ondokuzmayi{dotless}s University, Faculty of Medicine, Department of Pulmonary Medicine between 2001 and 2004. The response rates were 30.3% in adults and 28.8% in elderly patients. The median survival was 13.6±1.4 months and 11.8±2.0 months for adults and elderly patients, respectively. The one-year, two year and five year survival rates were 37%, 9%, 4% for adult patients and 29%, 7%, 4% for elderly patients, respectively. There was no statistical difference between the groups. Percentages of grade 3-4 anemia (0% vs 6.6%) and grade 3-4 neutropenia (0% vs 4.4%) were higher in elderly patients than adult patients. Other toxic effects were similar among both of groups. In conclussion; standart cisplatin containing chemotherapy regimens (cisplatin plus gemcitabine or vinorelbine) can be used in elderly patients with advanced non-small cell lung cancer. Source


Yilmaz M.,Bursa Ihtisas Training And Research Hospital | Arican Ozluk F.O.,Bursa Ihtisas Training And Research Hospital | Peker T.,Bursa Ihtisas Training And Research Hospital | Bekler A.,Medicalpark Hospital | Karaagac K.,Bursa Ihtisas Training And Research Hospital
Turkish Journal of Medical Sciences | Year: 2013

Aim: To investigate right ventricular function using conventional and tissue Doppler echocardiography in patients with coronary slow flow. Materials and methods: Twenty-two patients with slow coronary flow and 22 healthy subjects were included in the study. Right ventricular function was evaluated by conventional and tissue Doppler echocardiography. Additionally, right ventricular global function was assessed by myocardial performance index. Results: The tricuspid annulus peak early diastolic velocity (11.4 ± 2.2 cm/s, 13.9 ± 3 cm/s) and ratio of early to late diastolic velocity (0.70 ± 0.17 cm/s, 1.2 ± 0.38 cm/s) were lower in the patient group than in the controls (P = 0.05, P = 0.002, respectively). Late diastolic velocity (16.4 ± 3 cm/s, 14.4 ± 3 cm/s) and isovolumetric relaxation time (80 ± 9 ms, 66 ± 4 ms) were significantly higher in the patient group than in the controls (P = 0.024, P < 0.001, respectively). Right ventricular myocardial performance index was significantly prolonged in the coronary slow flow group (0.51 ± 0.03, 0.40 ± 0.02, P < 0.001). TIMI frame count was negatively correlated with the tricuspid lateral annulus early diastolic velocity and the ratio of tricuspid lateral annulus early to late diastolic velocity, whereas it was positively correlated with tricuspid isovolumetric relaxation time and right ventricular myocardial performance index. Conclusion: Right ventricular diastolic dysfunction exists in patients with the coronary slow flow phenomenon and it is correlated with TIMI frame count. © TÜBİTAK. Source


Yilmaz M.,Bursa Ihtisas Training And Research Hospital | Arican Ozluk F.O.,Bursa Ihtisas Training And Research Hospital | Akgumus A.,Bursa Ihtisas Training And Research Hospital | Peker T.,Bursa Ihtisas Training And Research Hospital | And 3 more authors.
Acta Cardiologica | Year: 2013

Objective Metabolic syndrome (MS) is a cluster of risk factors leading to cardiometabolic diseases. The aim of the present study was to investigate the eff ect of MS on left atrial function, which is an important determinant of left ventricular filling. Methods Left atrial (LA) volumes were measured echocardiographically in 32 MS patients and 32 age- and sex-matched controls. LA volumes were determined at the time of mitral valve opening (maximal, Vmax), at the onset of atrial systole (p wave on the electrocardiogram, Vp) and at the mitral valve closure (minimal, Vmin) according to the biplane area-length method in apical 4-chamber and 2-chamber view. All volumes were corrected to the body surface area, and following left atrial emptying functions were calculated. LA passive emptying volume = Vmax - Vp, LA passive emptying fraction = LA passive emptying volume/Vmax. Conduit volume = LV stroke volume - (Vmax - Vmin), LA active emptying volume = Vp - Vmin, LA active emptying fraction = LA active emptying volume/Vp, LA total emptying volume = (Vmax -Vmin), LA total emptying fraction = LA total emptying volume/Vmax. Results LA maximal volume and LA presystolic volume were significantly higher in MS patients than in controls (P < 0.001). But LA minimum volume was significantly lower in MS patients than in controls (P < 0.001). Although LA passive emptying volume (P < 0.03), LA passive emptying fraction (P < 0.001) and conduit volume (P < 0.001) were found to be significantly lower in MS patients than in controls, LA active emptying volume (P < 0.001) and LA active emptying fraction (P < 0.001) were significantly greater in MS patients than in controls. Conclusion In our study, metabolic syndrome was associated with increased left atrial volume, decreased left atrial passive emptying function and increased pump function. Increased left atrial pump function represents a compensatory mechanism in patients with MS. Thus, these results underline the importance of maintaining a sinus rhythm in these patients. Source


Kalkan G.,Gaziosmanpasa University | Yigit S.,Gaziosmanpasa University | Karakus N.,Gaziosmanpasa University | Bas Y.,Gaziosmanpasa University | And 2 more authors.
Journal of Dermatology | Year: 2013

Recurrent aphthous stomatitis (RAS) has a multifactorial etiopathogenesis, an interaction between predisposing factors and/or systemic conditions and immunological components in genetically predisposed subjects. The Mediterranean fever (MEFV) gene has already been identified as being responsible for familial Mediterranean fever. Because the association between MEFV gene mutations and Behçet's disease has been reported before in several studies, we considered that the role of MEFV gene mutations should be studied in patients with RAS, because of the clinical similarities of both diseases. The aim of this study was to explore the frequency and clinical significance of MEFV gene mutations in a cohort of Turkish patients with RAS. The study population comprised 100 unrelated patients with a clinical diagnosis of RAS and 156 healthy controls. Genomic DNA was isolated and genotyped using polymerase chain reaction and restriction fragment length polymorphism for the four MEFV gene mutations (M694V, M680I, V726A and E148Q). There were statistically significant differences of the MEFV gene mutation carrier rates and allele frequencies between RAS patients and healthy controls (P = 0.042, odds ratio [OR] = 1.9, 95% confidence interval [CI] = 1.01-3.41; and P = 0.039, OR = 1.8, 95% CI = 1.02-3.14, respectively). Even if it is not statistically significant, the E148Q allele frequency was higher in patients with RAS than the control group. A statistically significant increased prevalence of MEFV variants in RAS patients was found. This is the first study to report that missense mutations of MEFV is associated with RAS in the Turkish population. © 2013 Japanese Dermatological Association. Source


Celik M.,Van Military Hospital | Tuncer M.,Medicalpark Hospital | Tuzun N.,Van Military Hospital
Eastern Journal of Medicine | Year: 2012

Coronary arterial microfistulae are abnormal connections between one or multiple coronary arteries and any cardiac chamber. The frequency of this rare congenital anomaly is not known exactly, because at least 75% of cases may be asymptomatic. The diagnosis of the microfistulae is based on coronary angiography. Source

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