Pleven, Bulgaria

Medical University-Pleven
Pleven, Bulgaria

Medical University Pleven is one of the five medical institutions of higher education in Bulgaria. It is the only university in Pleven and was founded in 1974 on the basis of the former regional hospital established in 1865.The university unifies a large modern preclinical base, a hospital with specialised clinics, and research sections. It has two faculties, the Faculty of Medicine covering the subjects of medicine and rehabilitation and occupational therapy, and the Faculty of Public Health covering health care, as well as a college. There are also two hostels with a total of 315 beds in two- and three-bed rooms.As of the 2000s, Medical University Pleven has had 4081 Bulgarian and 582 foreign students from 45 countries, and has about 750 students a year, of which half are Bulgarians and the rest foreigners, 50-60% of whom are from India. Since Bulgaria's ascension to the European Union in 2007, most international students originate from other EU member states.The instruction courses in the university are carried out in two faculties and one college: Faculty of Medicine with the speciality of Medicine; Faculty of Public Health with the following specialities: Management of Health Care; Medicinal Rehabilitation and Occupational Therapy; Health Management; Nursing Midwifery. Medical College Pleven with the following specialities: Medical Laboratory Assistant; Radiology Laboratory Assistant; Social Worker. Wikipedia.

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Labek G.,Innsbruck Medical University | Todorov S.,Medical University-Pleven | Iovanescu L.,University Arad | Stoica C.I.,Foisor Orthopaedic Hospital | Bohler N.,Linz General Hospital
International Orthopaedics | Year: 2013

Purpose: The data currently available concerning total ankle arthroplasty (TAA) does not allow valid conclusions in several clinically relevant areas. Total ankle arthroplasty imposes special requirements on the methodology of data collection, evaluation, publication and the assessment of register data. Methods: We undertook a structured and descriptive analysis of all outcome data available from high-quality national arthroplasty registers worldwide. Register data from Sweden, Finland, Norway, New Zealand and Australia were included in the analysis. Results: There are marked differences between Europe and Oceania with respect to indications. All data sets show revision rates of approximately 10 % at five years, of which about 40 % of cases are for aseptic loosening. Inlay fractures are relatively common, which indicates potential for the improvement of implants. The documentation of intraoperative surgical errors leading to revision surgery varies significantly among registers. A relevant number of complications are treated without an implant component being exchanged and therefore not covered by a register. Conclusions: The results of TAA are promising, but the revision rate is higher than for total hip or knee arthroplasty. TAA outcome measurement by means of registers has several specific requirements necessitating additional documentation beyond the basic data set. For methodological reasons the evaluation of results is more complex than for hip or knee arthroplasty. It will therefore be essential to standardise data collection and evaluation and develop a methodology addressing the specific needs of TAA. © 2013 Springer-Verlag Berlin Heidelberg.

Sharma S.K.,All India Institute of Medical Sciences | Sharma S.K.,Medical University-Pleven | Mohanan S.,All India Institute of Medical Sciences | Sharma A.,All India Institute of Medical Sciences
Chest | Year: 2012

About one-third of the world population has latent TB infection (LTBI), the majority of which is distributed in 22 high-burden countries. Early diagnosis and treatment of active TB remains the top priority in resource-poor countries with high TB prevalence. Notwithstanding, because LTBI contributes significantly to the pool of active TB cases later on, its diagnosis and treatment is essential, especially in high-risk groups. The lack of a gold standard and several limitations of currently available tools, namely the tuberculin skin test and interferon-γ release assays, are major constraints for LTBI diagnosis. In areas with high TB prevalence, interferon-γ release assays have not shown superiority over the conventional tuberculin skin test and are yet to be systematically studied. Decisions regarding LTBI treatment with isoniazid preventive therapy should be made, keeping in mind the high prevalence of isoniazid resistance in these settings. Although efforts to shorten the LTBI treatment duration are encouraging, most trials have focused on adherence and toxicity. Future trials on short-duration regimens in high-burden settings should address drug efficacy issues as well. LTBI management, therefore, should comprise a targeted screening approach and individualization of LTBI treatment protocols. In addition, efforts should focus on airborne infection control measures in high-burden countries. A high prevalence of drug-resistant TB, the HIV epidemic, and delays in the diagnosis of active TB cases are other major concerns in areas of high TB prevalence. There is ample space for further research in these countries, whose outcomes may strengthen future national guidelines. © 2012 American College of Chest Physicians.

Down syndrome (DS) is the most common chromosome disorder among live born babies and the most common genetic cause of mental retardation. Aim of the study was to summarize the clinical and genetic information of Down syndrome (DS) cases, established in the Section of Medical Genetics, Medical University of Pleven for the period (January 2006-May 2014). A total of 55 children with DS were diagnosed by routine cytogenetic analysis. The clinical and passport data were taken from medical and genetic records. Most (90%) of the patients were diagnosed before 1 year age (53% in the first week after birth), because of dysmorphic features for DS. The distribution of DS cases, according to cytogenetic variant was as follows: 91% standard trisomy 21, 5.4% mosaic and 3.6% translocation DS. About 29% (16/55) of DS individuals have disease-associated congenital anomalies (mainly heart malformations 25%). Maternal age 36 ys at the time of birth had 40% of the women. Maternal serum screening test was not offered during pregnancy in the majority 85% (47/55) of mothers. About 73% (40/55) of children with DS are grown of their biological parents. Down syndrome is usually diagnosed early after birth, mainly in the early neonatal period. Most 60% of DS |children have young mothers (under 36 years old). About 1 /3 of DS individuals have associated anomalies (mainly heart defects). There is an insufficiency in offering the screening test to pregnant women that restrict their opportunity for early prenatal diagnosis of this condition and informed reproductive decision.

Georgieva S.,Medical University-Pleven
General Medicine | Year: 2015

Health promotion, as a modem concept for public health improvement, identifies new priorities for health interventions aimed at integrated approach to health, personal and social responsibility and partnership for its formation and preservation. By the international network "Health Promoting Schools", school community became the main environment for the implementation of the concept. The aim of the study is to put together traditional and innovative approaches to health promotion at school and their actual fulfillment in the Bulgarian schools. Literature review on the issue and data from own empirical study among a representative sample of schools in the region of Pleven were used. The results ascertain the fact that the concept of health promotion have to became more popular among school community to reach its full potential for public health improvement.

Israel M.,Medical University-Pleven
Electromagnetic Biology and Medicine | Year: 2015

The exposure and risk evaluation process in Bulgaria concerning non-ionizing radiation health and safety started in the early 1970s. Then, the first research laboratory "Electromagnetic fields in the working environment" was founded in the framework of the Centre of Hygiene, belonging to the Medical Academy, Sofia. The main activities were connected with developing legislation, new equipment for measurement of electromagnetic fields, new methods for measurement and exposure assessment, in vivo and human studies for developing methods, studying the effect of non-ionizing radiation on human body, developing exposure limits. Most of the occupations as metal industry, plastic welding, energetics, physiotherapy, broadcasting, telephone stations, computer industry, etc., have been covered by epidemiological investigations and risk evaluation. In 1986, the ANSI standard for safe use of lasers has been implemented as national legislation that gave the start for studies in the field of risk assessment concerning the use of lasers in industry and medicine. The environmental exposure studies started in 1991 following the very fast implementation of the telecommunication technologies. Now, funds for research are very insignificant, and studies in the field of risk assessment are very few. Nevertheless, Bulgaria has been an active member of the WHO International EMF Project, since 1997, and that gives good opportunity for collaboration with other Member states, and for implementation of new approach in the EMF policy for workers and peoples protection against non-ionizing radiation exposure. © 2015 Taylor & Francis.

The study analyzed the differential growth of the relative changes in the number of medicinal products in the reimbursement list and the corresponding relative change in the amount of public expenditure in Bulgaria for a ten-year period (2004-2013). For this purpose, data from the reimbursement lists for the respective years and accounts for the cash execution of the budget of the National Health Insurance Fund were used. Annually, since 2008 a double-digit growth in the number of reimbursed medicines is registered, with a similar dynamics of the amount of public expenditure. Additional conditions for the inclusion of medicinal products in the positive and reimbursement lists are proposed, with the aim to optimize the control of both the public and personal expenses in the cost of drug therapy.

Angelov I.,Medical University-Pleven
Problems of Infectious and Parasitic Diseases | Year: 2011

Dirofilariasis caused by D. repens is a natural-focal zoonosis. Dogs are the main dead-end host and reservoir of the parasite, and mosquitoes of the Aedes, Anopheles I{cyrillic} Culex families are vectors. Humans are non-specific, accidental host and not a source of infection. Canine dirofilariasis is found in the southern and eastern parts of Europe. Isolated cases of human dirofilariasis in Bulgaria have been reported during the last decades. We report a case of subconjunctival localization of dirofilariasis. A lithe helminth of cylindrical shape, 14 cm in length was extracted from the subconjunctival space. The histological examination of the helminth revealed a cuticle with longitudinal ridges with transverse striations. The size of the parasite, the typical localization and the morphology of the tegument made us assume that the case described was one of ophthalmic dirofilariasis caused by D. repens.

Petkova T.,Medical University-Pleven
General Medicine | Year: 2015

Varicella is a mild infection occurring in childhood, which GPs encounter in daily practice. In temperate zones over 90% of women of childbearing age have immunity against the disease. In recent years, in our country the infection tends to become 'older' and the related with it complications in pregnant women are worrying. Distribution and current recommendations for diagnosis and prevention of chickenpox in pregnant women are presented in this literary review. Bulletins of WHO, CDC, ECDC and other literary sources expressing the position of the leading experts on the diagnostic and therapeutic approach in these cases are used for this purpose.

Gancheva G.I.,Medical University-Pleven
Brazilian Journal of Infectious Diseases | Year: 2013

Leptospirosis is a re-emerging zoonosis with broad clinical spectrum and high mortality in severe forms. The aim of this study was to analyze clinical manifestations, laboratory findings, epidemiological data, and management in elderly patients with leptospirosis. Toward that end, we performed a descriptive analysis of 15 leptospirosis elderly cases (age 60-78 years) treated at the Clinic of Infectious Diseases of University Hospital - Pleven (1976-2012). Patients were serologically confirmed by microscopic agglutination test. Twelve cases (80%) presented with the severe form of leptospirosis. Co-morbidity (hypertonic diseases, chronic pulmonary diseases, chronic alcohol abuse, and diabetes) was registered in 13 cases. All cases had fever, oliguria, conjunctival suffusions, hepatosplenomegaly. Jaundice (14/93%), hemorrhagic diathesis (13/87%), vomiting (11/73%), abdominal pain (10/67%), myalgia (7/47%) and hypotension (7/47%) also were observed. Renal dysfunction was expressed by increased blood urea nitrogen (mean 38.1 ± 24.1. mmol/L) and serum creatinine (mean 347.6 ± 179.8. μmol/L). Hepatic dysfunction was expressed by increased total serum bilirubin level (mean 274.6 ± 210.7. μmol/L) and slightly elevated aminotransferases (ASAT mean 125.8 ± 61.6. IU/L; ALAT mean 131.3 ± 126.5. IU/L). Five cases (33%) had a lethal outcome. In conclusion, leptospirosis in elderly patients is associated with severe course and higher risk for death, and requires prompt intensive treatment. © 2013 Elsevier Editora Ltda.

Alexandrova M.L.,Medical University-Pleven | Danovska M.P.,University Hospital
Journal of Clinical Neuroscience | Year: 2011

There is no effective treatment for spontaneous intracerebral hemorrhage (sICH). We examined 46 patients with sICH within 48 hours after onset of symptoms, aiming to assess the predictive value of C-reactive protein (CRP) and lipid hydroperoxides (ROOH) on "first-week mortality" and "clinical outcome at discharge" by binary logistic regression. We found that serum CRP and hematoma volume were predictors of short-term mortality. Although serum ROOH level was positively correlated with mortality, it did not predict early lethal outcome. Serum ROOH concentration, however, was a predictor of poor clinical outcome in sICH survivors. After confirmation of the results obtained through observing a larger group of patients, an oxidative stress marker could be used as an additional criterion for patient stratification, especially when severe disability is expected and supplementary therapeutic approaches are urgent. © 2010 Elsevier Ltd. All rights reserved.

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