Medical University of Lublin
Lublin, Poland

Medical University of Lublin has its origins in the year 1944 in Lublin, Poland. The University gained its autonomy in 1950. As the years passed, new departments were added such as the Department of Dentistry in 1973. An agreement with the Hope Medical Institute from the United States was signed in the early 1990s, which initiated a program of teaching medicine to English-speaking students at the Medical University of Lublin. Thereafter a 4 year MD program was formed.The teaching program covers all branches of modern medicine and is comparable to medical programs in the US. Through its partner Hope Medical Institute, the Medical University provides the last two years of medical school to eligible students in the US and Canada.The University maintains lively international scientific contacts in cooperation Hvidovre Hospital in Copenhagen, Denmark; Ziekenhuis-Tilburg Hospital , and Lvov Medical University located in Ukraine, among others. Wikipedia.

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Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-23-2014 | Award Amount: 6.96M | Year: 2015

Childrens health affects the future of Europe children are citizens, future workers, parents and carers. Children are dependent on society to provide effective health services (UN Convention on the Rights of the Child). Models of child primary health care vary widely across Europe based on two broad alternatives (primary care paediatricians or generic family doctors), and a variety of models of school health and adolescent direct access services. There is little research to show which model(s) are best, implying that some are inefficient or ineffective, with sub-optimal outcomes. MOCHA will draw on networks, earlier child health projects and local agents to model and evaluate child primary care in all 30 EU/EEA countries. Scientific partners from 11 European countries, plus partners from Australia and USA, encompassing medicine, nursing, economics, informatics, sociology and policy management, will: Categorise the models, and school health and adolescent services Develop innovative measures of quality, outcome, cost, and workforce of each, and apply them using policy documents, routine statistics, and available electronic data sets Assess effects on equality, and on continuity of care with secondary care. Systematically obtain stakeholder views. Indicate optimal future patterns of electronic records and big data to optimise operation of the model(s). The results will demonstrate the optimal model(s) of childrens primary care with a prevention and wellness focus, with an analysis of factors (including cultural) which might facilitate adoption, and indications for policy makers of both the health and economic gains possible. The project will have a strong dissemination programme throughout to ensure dialogue with public, professionals, policy makers, and politicians. The project will take 42 months (36 of scientific work plus start up and close), and deliver major awareness and potential benefit for European childrens health and healthy society.

Beltowski J.,Medical University of Lublin
Pharmacological Reports | Year: 2015

Hydrogen sulfide (H2S) is the endogenously produced gasotransmitter involved in the regulation of nervous system, cardiovascular functions, inflammatory response, gastrointestinal system and renal function. Together with nitric oxide and carbon monoxide, H2S belongs to a family of gasotransmitters. H2S is synthesized from l-cysteine and/or l-homocysteine by cystathionine β-synthase, cystathionine γ-lyase and cysteine aminotransferase together with 3-mercaptopyruvate sulfurtransferase. Significant progress has been made in recent years in our understanding of H2S biochemistry, signaling mechanisms and physiological role. H2S-mediated signaling may be accounted for not only by the intact compound but also by its oxidized form, polysulfides. The most important signaling mechanisms include reaction with protein thiol groups to form persulfides (protein S-sulfhydration), reaction with nitric oxide and related species such as nitrosothiols to form thionitrous acid (HSNO), nitrosopersulfide (SSNO-) and nitroxyl (HNO), as well as reaction with hemoproteins. H2S is enzymatically oxidized in mitochondria to thiosulfate and sulfate by specific enzymes, sulfide:quinone oxidoreductase, persulfide dioxygenase, rhodanese and sulfite oxidase. H2S donors have therapeutic potential for diseases such as arterial and pulmonary hypertension, atherosclerosis, ischemia-reperfusion injury, heart failure, peptic ulcer disease, acute and chronic inflammatory diseases, Parkinson's and Alzheimer's disease and erectile dysfunction. The group of currently available H2S donors includes inorganic sulfide salts, synthetic organic slow-releasing H2S donors, H2S-releasing non-steroidal antiinflammatory drugs, cysteine analogs, nucleoside phosphorothioates and plant-derived polysulfides contained in garlic. H2S is also regulated by many currently used drugs but the mechanism of these effects and their clinical implications are only started to be understood. © 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.2.2 | Award Amount: 4.06M | Year: 2013

In the frame of the project ReMeDi a robot system is designed that features medical tele-examination of patients. Successful medical treatment depends on a timely and correct diagnosis, but the availability of doctors of various specializations is limited, especially in provincial hospitals or after regular working hours. Medical services performed remotely are emerging, yet current solutions are limited to merely teleconferencing and are insufficient. Use case scenarios targeted in ReMeDi feature a robot capable of performing a physical examination, specifically of the two most widespread examination techniques i) palpation, i.e. pressing the patients stomach with the doctors hand and observing the stiffness of the internal organs and the patients feedback (discomfort, pain) as well as ii) ultrasonographic examination. Beside quality teleconferencing, ReMeDi features a mobile robot (placed in a hospital) equipped with a lightweight and inherently safe manipulator with an advanced sensorized head and/or ultrasonic probe; and the remote interface (placed at the doctors location) equipped with sophisticated force-feedback, active vision and locomotion capabilities. The system is incrementally built following a user-centered design approach, and its usability with respect to the patient and the examining doctor is extensively studied in real world scenarios of cardiac examination. ReMeDi will go beyond classical telepresence concepts: It will capture and process multi-sensory data (integrating visual, haptic, speech, patients emotions and physiological responses) into perception and reasoning capabilities making ReMeDi a diagnostic assistant offering context-dependent and proactive support for the doctor. Particular attention is devoted to safety aspects. The normative standards (both existing and in draft) and the results of ongoing research projects will be integrated in all the system development phases.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-19-2014 | Award Amount: 3.98M | Year: 2015

RAMCIP will research and develop a novel domestic service robot, with the aim to proactively and discreetly assist older persons, MCI and AD patients in their every day life. Instead of simply being an obedient servant, the RAMCIP robot will have high-level cognitive functions, driven through advanced human activity and home environment modelling and monitoring, enabling it to optimally decide when and how to assist. The robot will provide subtle physical and cognitive user skills training, by maintaining an optimal balance between physical assistance provision and user stimulation to act. The cognitive functions will orchestrate an ensemble of advanced lower-level mechanisms, enabling the robot to (a) communicate with the user and (b) establish dextrous and safe robotic manipulations. Communication will be based on multimodal interfaces, adapted and fused so as to meet the current users needs and interaction context. Apart from touch-screen, speech and gestural modalities, RAMCIP will incorporate an augmented reality display, as well as an underlying empathic communication channel, allowing it to sense user affect and moderate it. In the context of robotic manipulations, RAMCIP will introduce advanced dexterity in service robots for assisted living environments; the robot will employ a sophisticated anthropomorphic hand, manipulated though novel grasping and dexterity algorithms, being capable to grasp and manipulate a variety of objects in realistic user homes, supporting also safe handover. Safety will be a major research focus. By establishing safe and dextrous manipulations, emphasis will be paid on physical HRI, enabling novel assistance scenarios that will involve physical contact between the user and the robot. Through multi-faceted proactive assistance enabled through all the above, RAMCIP will advance user independency and quality of life of its user. The robot will be evaluated in two pilot sites that will be deployed in two countries.

Biomolecules are widespread throughout the world. A biomolecule is any organic molecule produced by a living organism, including large polymeric molecules such as proteins, polysaccharides and nucleic acids. Many sample preparation techniques are used in biomolecule analysis; the method selected depends on the complexity of the sample, the nature of the matrix and the analytes, and the analytical technique available. This review covers the current state of knowledge on thin-layer chromatography and mass spectrometry for qualitative analysis of biomolecules. In the first part of the paper the reader will gain useful information to avoid some problems about performing various modes of thin-layer chromatography combined with mass spectrometry experiments and in the second part he will find useful information for application of these techniques for separation, detection, and qualitative investigation of structures and quantitative determination of biomolecules such as proteins, peptides, oligonucleotides, amino acids, DNA, RNA, and lipids. © 2011 Elsevier B.V.

The addition of the homologous series of perfluorinated acids-trifluoroacetic acid (TFAA), pentafluoropropionic acid (PFPA), heptafluorobutyric acid (HFBA) to mobile phases for reversed-phase high-performance liquid chromatography (RP-HPLC) of β-blockers was tested. Acidic modifiers were responsible for acidification of mobile phase (pH 3) ensuring the protonation of the β-blockers and further ion pairs creation. The effect of the type and concentration of mobile phase additives on retention parameters, the efficiency of the peaks, their symmetry and separation selectivity of the β-blockers mixture were all studied. It appeared that at increasing acid concentration, the retention factor, for all compounds investigated, increased to varying degrees. It should be stressed that the presence of acids more significantly affected the retention of the most hydrophobic β-blockers. Differences in hydrophobicity of drugs can be maximized through variation of the hydrophobicity of additives. Thus, the relative increase in the retention depends on either concentration and hydrophobicity of the anionic mobile phase additive or hydrophobicity of analytes. According to QSRR (quantitative structure retention relationship) methodology, chromatographic lipophilicity parameters: isocratic log k and log kw values (extrapolated retention to pure water) were correlated with the molecular (log Po/w) and apparent (log Papp) octanol-water partition coefficients obtained experimentally by countercurrent chromatography (CCC) or predicted by Pallas software. The obtained, satisfactory retention-hydrophobicity correlations indicate that, in the case of the basic drugs examined in RP-HPLC systems modified with perfluorinated acids, the retention is mainly governed by their hydrophobicity. © 2009 Elsevier B.V. All rights reserved.

Morshed K.,Medical University of Lublin
Journal of Medical Virology | Year: 2010

The aim of this study was to compare the prevalence of human papillomavirus (HPV) infection in laryngeal squamous cell carcinoma using two methods: PCR-DNA enzyme immunoassay (PCR/DEIA)andimmunohistochemistry (IHC) for detection of HPV in specimens of laryngeal squamous cell carcinoma and to correlate the presence of HPV with the epidemiological and clinicopathological features of recurrence and survival. HPV DNA was amplified from 93 paraffin-embedded laryngeal squamous cell carcinoma tissue specimens by the short PCR fragment (SPF 10) primer set using PCR/DNA method. HPV detection using monoclonal anti-human papilloma virus antibodies Clone K1H8 for IHC reaction was performed on 130 specimens. HPV was identified in 35.5% of patients with laryngeal squamous cell carcinoma using PCR/DEIA and 27.7% using IHC. There was no statistically significant association between the presence of HPV and the epidemiological and clinicopathological features and recurrence. There was no statistically significant association between the presence of HPV and overall survival nor disease specific survival. Statistically significant correlation between HPV detection using PCR/DEIA technique and IHC technique was found. The presence of HPV infection in 27.7% and 38.9% of the patients suggests a possible role in the etiology of laryngeal squamous cell carcinoma. The SPF10 PCR/DEIA technique is the most accurate method for detection of HPV in laryngeal squamous cell carcinoma. © 2010 Wiley-Liss, Inc.

Beltowski J.,Medical University of Lublin
Clinical and Experimental Pharmacology and Physiology | Year: 2012

Obesity and the accompanying metabolic syndrome are among the most important causes of cardiovascular pathologies associated with endothelial dysfunction, such as arterial hypertension and atherosclerosis. This detrimental effect of obesity is mediated, in part, by excessive production of the adipose tissue hormone leptin. Under physiological conditions leptin induces endothelium-dependent vasorelaxation by stimulating nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). Leptin activates endothelial NO synthase (eNOS) through a mechanism involving AMP-activated protein kinase (AMPK) and protein kinase B/Akt, which phosphorylates eNOS at Ser 1177, increasing its activity. Under pathological conditions, such as obesity and metabolic syndrome, the NO-mediated vasodilatory effect of leptin is impaired. Resistance to the acute NO-mimetic effect of leptin is accounted for by chronic hyperleptinaemia and may result from different mechanisms, such as downregulation of leptin receptors, increased levels of circulating C-reactive protein, oxidative stress and overexpression of suppressor of cytokine signalling-3. In short-lasting obesity, impaired leptin-induced NO production is compensated by EDHF; however, in advanced metabolic syndrome, the contribution of EDHF to the haemodynamic effect of leptin becomes inefficient. Resistance to the vasodilatory effects of leptin may contribute to the development of arterial hypertension owing to unopposed stimulation of the sympathetic nervous system by this hormone. © 2011 The Author. Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.

Thirumurugan P.,Medical University of Lublin | Matosiuk D.,Medical University of Lublin | Jozwiak K.,Medical University of Lublin
Chemical Reviews | Year: 2013

Researchers explore the potential of click chemistry for drug development and diverse chemical-biology applications. Click chemistry is a newer approach to the synthesis of drug-like molecules that can accelerate the drug discovery process by utilizing a few practical and reliable reactions. Researchers have defined the click reaction as wide in scope and easy to perform, which uses only readily available reagents and is insensitive to oxygen and water. Some of the attributes of click reactions include many of these components being derived from derived from alkenes and alkynes, along with from the cracking of petroleum and many of these reactions involve the formation of carbon-heteroatom bonds. Click chemistry-based drug discovery are mainly of three types, such as high-throughput screening, fragment-based drug discovery, and dynamic template-assisted strategies in fragment-based drug discovery.

Beltowski J.,Medical University of Lublin
Journal of Pharmacology and Experimental Therapeutics | Year: 2010

Hydrogen sulfide (H2S) is enzymatically generated in mammalian tissues from either L-cysteine or L-homocysteine. H2S possesses multiple biological activities, including regulation of vascular tone and blood pressure. Hydrogen sulfide produced in endothelial cells, vascular smooth muscle cells, and perivascular adipose tissue dilates blood vessels by activating ATP-sensitive potassium channels. In addition, H2S produced locally within the kidney stimulates natriuresis and diuresis by increasing glomerular filtration and inhibiting tubular sodium reabsorption. Because H2S is oxidized in mitochondria in pO2-dependent manner and ambient pO 2 is physiologically low in the renal medulla, it is expected that the activity of H2S is higher in the medullary region than the cortical region. H2S, accumulating in increased amounts in the renal medulla under hypoxic conditions, may function as an oxygen sensor that restores O2 balance by increasing medullary blood flow, reducing energy requirements for tubular transport, and directly inhibiting mitochondrial respiration. Hypoxia is an important pathogenic factor in many renal diseases, such as ischemia/reperfusion- or nephrotoxin-induced acute renal failure, progression of chronic nephropathies, diabetic nephropathy, and arterial hypertension. Deficiency of endogenous H2S may contribute to the pathogenesis of these pathologies by compromising medullary oxygenation, and administration of H2S donors may be of therapeutic value in these disorders. Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics.

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