Medical Laboratory Technology

Delhi, India

Medical Laboratory Technology

Delhi, India
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Bashir R.,Lahore Medical and Dental College | Imtiaz S.,Lahore Medical and Dental College | Yasir M.,Medical Laboratory Technology | Raza H.,Lahore Medical and Dental College | Shah S.M.A.,PIC
Pakistan Journal of Medical and Health Sciences | Year: 2010

Background with aims and objectives: In last two decades, a multitude of clinical studies have investigated the role of cystatin C as a marker of kidney function. Cystatin C belongs to family 2 of the super family of cysteine protease inhibitors. It is produced in all the nucleated cells of the human body and its production rate is constant. Cystatin C is present in all human body fluids. The study was conducted to investigate the effect of Body Mass Index (BMI) on serum cystatin C in healthy population. Study Design: Analytical cross-sectional. Materials and Methods: Eighty five healthy subjects both males and female ages 18-60 years were included in this study group. These subjects were divided into three groups based on BMI as control, over weight and obese. Serum cystatin C was measured by ELISA. Results: The serum cystatin C level was significantly high in over weight and obese groups as compared to control group in both males and females. Conclusion: The present study suggests that BMI affects serum cystatin C level.


PubMed | Applied Microbiology and Biotechnology, Medical Laboratory Technology, Vindico NanoBioTechnology Inc., Medicity and Biotechnology
Type: Journal Article | Journal: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion | Year: 2015

With an increase in the number of transplants happening globally, hematopoietic stem cells (HSC) transplantation from matched unrelated donor (MUD) has begun. The increasing trend of MUD transplants across countries has been largely facilitated with the conspicuous growth of volunteer HSC donor noted in the last decade i.e. 8 million HSC donors in 2002 to more than 22 million in 2013 registered in 71 member registries of the Bone Marrow Donor Worldwide (BMDW). Some populations of the world are still very poorly represented in these registries. Since, the chances of successful engraftment and disease free survival are directly proportional to the HLA compatibility between the recipient and the prospective donor, the diversity of the HLA system at the antigenic and allelic level and the heterogeneity of HLA data of the registered donors has a bearing on the probability of finding a volunteer unrelated HSC donor for patients from such populations. In the present study 126 patients were identified suffering from hematological diseases requiring MUD transplant. Their HLA typing was performed and search was done using BMDW database. The search results for these Indian patients in the multinational registry as well as in the Indian Registries were analyzed using mean, range, standard deviation and finally evaluated in terms of probability for finding matched donor (MUD). Total Asian population is only 11% in the BMDW making it difficult to find a MUD for an Asian patient. The current study supports this, experimentally; revealing that the probability of finding an allele match for an Indian patient in the multinational Human Leukocyte Antigen (HLA) registries is 16% and a dismal 0.008% in the Indian registries (donors in Indian registries is just 33,678 as compared to 22.5 million in BMDW). This greatly, emphasizes on enhancing the number of Indian donors in Indian and multi-national registries.


Tiwari A.K.,Medicity | Tiwari A.K.,Vindico NanoBioTechnology Inc. | Tiwari A.K.,Medical Laboratory Technology | Bhati-Kushwaha H.,Medicity | And 17 more authors.
Indian Journal of Hematology and Blood Transfusion | Year: 2015

With an increase in the number of transplants happening globally, hematopoietic stem cells (HSC) transplantation from matched unrelated donor (MUD) has begun. The increasing trend of MUD transplants across countries has been largely facilitated with the conspicuous growth of volunteer HSC donor noted in the last decade i.e. 8 million HSC donors in 2002 to more than 22 million in 2013 registered in 71 member registries of the Bone Marrow Donor Worldwide (BMDW). Some populations of the world are still very poorly represented in these registries. Since, the chances of successful engraftment and disease free survival are directly proportional to the HLA compatibility between the recipient and the prospective donor, the diversity of the HLA system at the antigenic and allelic level and the heterogeneity of HLA data of the registered donors has a bearing on the probability of finding a volunteer unrelated HSC donor for patients from such populations. In the present study 126 patients were identified suffering from hematological diseases requiring MUD transplant. Their HLA typing was performed and search was done using BMDW database. The search results for these Indian patients in the multinational registry as well as in the Indian Registries were analyzed using mean, range, standard deviation and finally evaluated in terms of probability for finding matched donor (MUD). Total Asian population is only 11 % in the BMDW making it difficult to find a MUD for an Asian patient. The current study supports this, experimentally; revealing that the probability of finding an allele match for an Indian patient in the multinational Human Leukocyte Antigen (HLA) registries is 16 % and a dismal 0.008 % in the Indian registries (donors in Indian registries is just 33,678 as compared to 22.5 million in BMDW). This greatly, emphasizes on enhancing the number of Indian donors in Indian and multi-national registries. © 2014, Indian Society of Haematology & Transfusion Medicine.

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