Medical Society for the Use of Ozone in Prevention and Therapy

Baden-Baden, Germany

Medical Society for the Use of Ozone in Prevention and Therapy

Baden-Baden, Germany

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Mawsouf M.N.,Cairo University | Tanbouli T.T.,New Life Specialized Clinics | Viebahn-Hansler R.,Medical Society for the Use of Ozone in Prevention and Therapy
Ozone: Science and Engineering | Year: 2012

Hepatitis C is a medical problem in Egypt. The usual line of treatment is very expensive, with major side effects and low efficacy especially in genotype 4, which is common in Egypt. Several studies were performed between 1999 and 2008 to evaluate the role of ozone therapy in HCV (Hepatitis C). The first study included 60 genotype 4 Hepatitis C patients, who received combined ozone treatment with major autohemotherapy three times per week for 8 weeks, followed by twice per week for 16 weeks. It was found that, following 8 weeks of ozone therapy, the viral load decreased in 91.67% of the cases attaining negative PCR in 20%. Following 24 weeks of ozone therapy, there was a further decrease in viral load reaching 95% of the cases, with a negative PCR level in 36.67%. After 8 weeks of ozone therapy, the abnormal enzyme levels were back to normal in 21.67% of the cases for the SGPT enzyme, and were back to normal in 20% for the SGOT enzyme. A second study included 50 genotype 4 Hepatitis C patients. The number of visits was three times per week for 12 weeks followed by twice per week for 12 weeks. The general condition improved in 94% of the cases. There was a decrease in quantitative PCR in 71.8% of the cases that reached negative PCR in 24% after 8 weeks' treatment. The number of negative PCR cases for HCV virus increased to cover 36% of the cases after 24 weeks' treatment. There was a statistically significant improvement as regards the parameters of SGOT, SGPT, albumin, bilirubin and prothrombin after 8 weeks from the start of the study. A third study was carried out on 30 HCV patients, yielding results similar to the previous two. © 2012 Copyright 2012 International Ozone Association.


Fathi A.M.,Navy Diving and Hyperbaric Medical Institute | Mawsouf M.N.,Cairo University | Viebahn-Hansler R.,Medical Society for the Use of Ozone in Prevention and Therapy
Ozone: Science and Engineering | Year: 2012

The objective of this study was to evaluate the role of ozone therapy (as a part of a comprehensive approach) with its different techniques in the management of diabetic foot problems and chronic nonhealing wounds. The study design included a case series study, with review of the literature. Researchers used an ozone therapy unit, a Navy Diving and Hyperbaric Medicine Institute, and Ozone Therapy Unit, at the Armed Forces Hospital, in Alexandria, Egypt. All patients with diabetic foot problems and chronic nonhealing wounds were treated with ozone therapy from August 2006 to August 2009. Full history and clinical examination to identify diagnosis, and determine therapeutic comprehensive approaches including ozone therapy treatment protocols. Observation notes on the practice of ozone techniques, progress of diseases and outcome were accurately documented. Data were reviewed against best practice described in the literature. We observed overall successful treatments in 87% (46% of them complete healing) of patients treated with ozone. We reported the general and topical effects of ozone correlated to the technique used. The present study offers the clinical evidence which supports and recommends the use of ozone in diabetic foot and chronic nonhealing wounds. Cooperation between surgeon and ozone therapist is a must for successful outcomes. Randomized controlled trials should be performed as an essential method for accurately proving the reliability, efficacy and possible side effects of ozone therapy, and to introduce ozone to the world of surgeons and clinicians. © 2012 Copyright 2012 International Ozone Association.


Diaz-SotoMari M.T.,University of Habana | Fraga Perez A.,University of Habana | Dranguet Vaillant J.,University of Habana | Mallok A.,University of Habana | And 3 more authors.
Ozone: Science and Engineering | Year: 2012

Chronic oxidative stress and acetaldehyde accumulation are associated with brain damage during Ethanol Withdrawal (EW). Ozone therapy is a regulator of cellular redox balance and it controls important functions of nervous system during EW at experimental level. The aim of this work was to develop a pilot study in order to evaluate the ozonés effects on EW signs and oxidative stress in 10 patients "Before" and "After" ozone treatments. Ozone improved 70% of the signs from Clinical Institute Withdrawal Scale (CIWA-Ar), mainly those associated to Central Nervous System (CNS). Ozonés efficacy was observed in patients that required pharmacological treatment. Reduction of CIWA-Ar scores and the oxidative stress (p < 0.05) was demonstrated. In summary, ozone improved CNS functions and reduced oxidative stress in patients during EW. These results were according to experimental findings and suggest ozonés regulator effects on important neurotransmitters of the CNS. © 2012 Copyright 2012 International Ozone Association.


Viebahn-Hansler R.,Medical Society for the Use of Ozone in Prevention and Therapy | Leon Fernandez O.S.,University of Habana | Fahmy Z.,Medical Society for the Use of Ozone in Prevention and Therapy
Ozone: Science and Engineering | Year: 2012

The low-dose ozone concept with its moderate oxidative stress represents an ideal hormesis strategy. Dose-response and concentration-effect relationships in the context with specific applications allow one to fix concentration ranges with therapeutical benefit. Based on the well-known reaction mechanisms of ozone, its biochemical and pharmacological effects, international guidelines have to be defined concerning physiological and ozone resistant materials, indications, applications and the effective concentration and dosage range in dependence on the specific indications. Following the international regulations of ozone concentrations outdoors and indoors, as working site concentrations by WHO (World Health Organization) and in conformance with the Medical Device Directives (MDD) for quality assurance and control, some European Medical Societies for the Use of Ozone have set up a draft for the essential requirements for the treatment procedures, including: (a) production of Medical Ozone; reactivity of O3 and ozone-resistant materials; (b) ozone-free surroundings (WHO regulations) by the integration of effective catalytic systems; (c) ozone-resistant and physiologically indifferent materials used in disposables for MAH, intra-articular, intramuscular and other topical injections (for rectal insufflation, topical treatment as transcutanous gas bath and/or disinfection); (d) medical device directives for safety of the patient; (e) ozone measurement as requirement for concentrations and dosages; and, (f) concentration, dosages, and treatment frequency are listed in dependence on the indication and disease as well as on the underlying mechanism of action. © 2012 Copyright 2012 International Ozone Association.


Diaz-SotoMari M.T.,University of Habana | Fraga Perez A.,University of Habana | Dranguet Vaillant J.,University of Habana | Mallok A.,University of Habana | And 3 more authors.
Ozone: Science and Engineering | Year: 2012

Ethanol withdrawal (EW) increases acetaldehyde accumulation and reactive oxygen species formation that promote damage to the brain. It is necessary to emphasize that while EtOH abuse and dependence are widespread, treatment options are extremely limited. This study aimed at investigating the protective effects of Ozone Oxidative Postconditioning (OzoneOxPost) on brain injury induced by oxidative stress and behavioral changes after 2 weeks of EW in rats. Four groups of rats (n = 10 each one) were settled: (I) Control, (II) Ethanol; (III) Ethanol + Ozone, and (IV) Ethanol + Oxygen. At the end of EW, rats were subjected to behavioral tests followed by brain tissue collection to measure markers of oxidative damage. OzoneOxPost increased food consumption, maintained water intake at the same levels as the control group, and reestablished cellular redox status. Anxiety, locomotor activity, and memory/learning of the rats were improved. These results demonstrated that OzoneOxPost protected the brain against oxidative injury, improving important functions of the Central Nervous Systems (CNS). It is a novel finding that is evidence of ozone's effects on CNS. © 2012 Copyright 2012 International Ozone Association.


Viebahn-Hansler R.,Medical Society for the Use of Ozone in Prevention and Therapy | Leon Fernandez O.S.,University of Habana | Fahmy Z.,Medical Society for the Use of Ozone in Prevention and Therapy
Ozone: Science and Engineering | Year: 2016

Now that indications are clearly defined, applications have mostly become standardized and the active mechanisms have been well confirmed, medical ozone application in the form of the low-dose concept, is established and proven as a complementary medical method in the treatment of chronic inflammations or diseases associated with chronic inflammatory conditions. More than 11,000 systemic ozone treatments in the form of Major Ozone Autohemotherapy (MAH) in 577 patients and ≥ 47,000 Rectal Insufflations (RI) in 716 patients in various clinical studies are subjected to critical clinical assessment and classification according to the criteria of evidence-based medicine (EBM). Statistically significant clinical and/or pharmacological improvements without side-effects or adverse reactions are found in all studies; special attention is drawn to maintaining hygiene when working with blood and to the use of ozone-resistent and biocompatible materials. On summarizing the evidence classification under RCT + CT (Randomized Controlled Trials + Controlled Trials), i.e., Levels Ib and IIa, 12 studies with 657 ozone-treated patients are obtained for MAH and 6 studies with 227 patients for RI. As a result of the evidence here assessed, the two systemic ozone applications, MAH and RI are part of evidence-based medicine. Both applications are effective, safe and economic. © 2016 International Ozone Association.


PubMed | Medical Society for the Use of Ozone in Prevention and Therapy, CEBIMAR, University of Habana and National Institute of Rheumatology
Type: | Journal: European journal of pharmacology | Year: 2016

Medical ozone reduced inflammation, IL-1, TNF- mRNA levels and oxidative stress in PG/PS-induced arthritis in rats. The aim of this study was to investigate the medical ozone effects in patients with rheumatoid arthritis treated with methotrexate and methotrexate+ozone, and to compare between them. A randomized clinical study with 60 patients was performed, who were divided into two groups: one (n=30) treated with methotrexate (MTX), folic acid and Ibuprophen (MTX group) and the second group (n=30) received the same as the MTX group+medical ozone by rectal insufflation of the gas (MTX+ozone group). The clinical response of the patients was evaluated by comparing Disease Activity Score 28 (DAS28), Health Assessment Questionnaire Disability Index (HAQ-DI), Anti-Cyclic Citrullinated (Anti-CCP) levels, reactants of acute phase and biochemical markers of oxidative stress before and after 20 days of treatment. MTX+ozone reduced the activity of the disease while MTX merely showed a tendency to decrease the variables. Reactants of acute phase displayed a similar picture. MTX+ozone reduced Anti-CCP levels as well as increased antioxidant system, and decreased oxidative damage whereas MTX did not change. Glutathione correlated with all clinical variables just after MTX+ozone. MTX+ozone increased the MTX clinical response in patients with rheumatoid arthritis. No side effects were observed. These results suggest that ozone can increase the efficacy of MTX probably because both share common therapeutic targets. Medical ozone treatment is capable of being a complementary therapy in the treatment of rheumatoid arthritis.

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