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Nickavar A.,Tehran University of Medical Sciences | Safaeian B.,Gorgan University Medical science | Sadeghi-Bojd S.,Zahedan University of Medical Sciences | Lahouti Harah dashti A.,Tehran University of Medical Sciences
Indian Journal of Pediatrics | Year: 2016

Objective: To find the value of urine neutrophil gelatinase associated lipocalin (NGAL) in differentiating steroid response in children with idiopathic nephrotic syndrome (INS). Methods: A total of 52 children with INS (n = 27, steroid resistant; n = 25, steroid responsive) aged 1–16 y, along with 18 healthy control children were enrolled in this study. Urine NGAL as well as urine protein, and serum creatinine were analyzed during active phase of INS. Results: Serum creatinine (P 0.032), and urine NGAL/Cr (P 0.001) were significantly higher in steroid resistant than steroid sensitive patients. The optimal cutoff value for urine NGAL/Cr with the highest sensitivity and specificity was 0.46 ng/mg and cut off value of 0.01 and 1.15 ng/mg had maximum sensitivity and specificity, respectively. Conclusions: Urine NGAL/Cr could be considered as a marker of steroid resistance in children with idiopathic nephrotic syndrome. © 2015, Dr. K C Chaudhuri Foundation.


PubMed | Zahedan University of Medical Sciences, Gorgan University Medical science and Tehran University of Medical Sciences
Type: Journal Article | Journal: Indian journal of pediatrics | Year: 2016

To find the value of urine neutrophil gelatinase associated lipocalin (NGAL) in differentiating steroid response in children with idiopathic nephrotic syndrome (INS).A total of 52 children with INS (n=27, steroid resistant; n=25, steroid responsive) aged 1-16 y, along with 18 healthy control children were enrolled in this study. Urine NGAL as well as urine protein, and serum creatinine were analyzed during active phase of INS.Serum creatinine (P 0.032), and urine NGAL/Cr (P 0.001) were significantly higher in steroid resistant than steroid sensitive patients. The optimal cutoff value for urine NGAL/Cr with the highest sensitivity and specificity was 0.46 ng/mg and cut off value of 0.01 and 1.15 ng/mg had maximum sensitivity and specificity, respectively.Urine NGAL/Cr could be considered as a marker of steroid resistance in children with idiopathic nephrotic syndrome.

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