Time filter

Source Type

De Groot N.S.,Laboratory of Molecular Biology Medical Research Council | De Groot N.S.,Autonomous University of Barcelona | Burgas M.T.,Laboratory of Molecular Biology Medical Research Council | Burgas M.T.,Autonomous University of Barcelona | Burgas M.T.,Vall dHebron Research Institute VHIR
Cellular and Molecular Life Sciences | Year: 2015

Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. Specifically, we describe the processes that generate such imbalances at the molecular level, and try to understand how they affect protein folding and localization. Overall, current knowledge suggests that microglia pro-inflammatory mediators can generate membrane damage, which may have an impact in terms of triggering or accelerating disease manifestation. © 2015 Springer Basel.


PubMed | Laboratory of Molecular Biology Medical Research Council
Type: Journal Article | Journal: Cellular and molecular life sciences : CMLS | Year: 2015

Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. Specifically, we describe the processes that generate such imbalances at the molecular level, and try to understand how they affect protein folding and localization. Overall, current knowledge suggests that microglia pro-inflammatory mediators can generate membrane damage, which may have an impact in terms of triggering or accelerating disease manifestation.

Loading Laboratory of Molecular Biology Medical Research Council collaborators
Loading Laboratory of Molecular Biology Medical Research Council collaborators