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Orlova M.A.,Moscow State University | Trofimova T.P.,Moscow State University | Filimonova M.V.,Medical Radiological Scientific Center | Proshin A.N.,Russian Academy of Sciences | Zaitsev D.A.,Moscow State University
Russian Chemical Bulletin

The effector activity of thiazine and thiourea derivatives towards various forms of NO-synthase (NOS) in vitro and ex vivo was compared with their cytotoxic effect on human lymphocytes and leukemic cells. A thiazine derivative was revealed that exhibits a selective effect only on malignant cells and is an inhibitor of inducible and neuronal NOS. © 2013 Springer Science+Business Media New York. Source

Lychagin A.A.,Medical Radiological Scientific Center
Biomedical Engineering

Portable neutron generators developed at the All-Russian Scientific Research Institute of Automatics (Moscow) and their potential applications for radiobiological experiments and therapy are considered. Experience in the use of such generators at the Medical Radiological Scientific Center, Ministry of Health of Russian Federation, is reviewed. © 2014 Springer Science+Business Media New York. Source

Plotnikova E.D.,Moscow State University | Nurieva E.V.,Moscow State University | Onufriev M.V.,Russian Academy of Sciences | Gulyaeva N.V.,Russian Academy of Sciences | And 4 more authors.
Russian Journal of Organic Chemistry

iNOS-Inhibitor activity of 3-imino-2,4-diazabicyclo[3.3.1]nonan-1-ol hydrochloride was predicted basing on molecular modeling and was confirmed by experiments in vitro. The results of the study by XRD analysis of the molecular and crystal structure of this compound are reported. © 2013 Pleiades Publishing, Ltd. Source

Osipov A.N.,RAS Semenov Institute of Chemical Physics | Ryabchenko N.I.,Medical Radiological Scientific Center | Ivannik B.P.,Medical Radiological Scientific Center | Ryabchenko V.I.,Medical Radiological Scientific Center

The effect of combined action of cadmium chloride at a dose of 0.5 mg/kg of body weight and γ-radiation of 1 Gy on induction of DNA damage in thymocytes and the total number of cells in the thymus of mice was studied. We found that injection of CdCl2 0.5 h prior to irradiation decreased the number of single-strand DNA breaks and the number of alkali-labile sites in thymocytes 48 h after irradiation as compared to the γ-radiation effect only. This effect was associated with a strong decrease in the total number of thymocytes in this organ as compared to the action of cadmium ions and γ radiation separately. This masked the general genotoxic effect of combined treatment and created an illusion of a radioprotective effect of cadmium ions. Injection of cadmium chloride into mice 24 h prior to irradiation was followed by an additive increase in the number of the single-strand DNA breaks and the number of alkali-labile sites in thymocytes as compared to the respective controls such as the separate effects of cadmium ions and irradiation. We revealed a simultaneous decrease in the part of DNA tightly bound to proteins, i. e., DNA-protein cross-links as compared to the effect of γ-radiation only. We did not observe any statistically significant changes in the total number of thymocytes as compared to the separate effects of cadmium ions and irradiation. Thus, our data show that exposure of murine thymocytes to combined action of cadmium ions and γ-radiation at the doses and with the methods of treatment used induced additive effects but not antagonistic effects or protection against radiation. © 2011 Pleiades Publishing, Ltd. Source

Skoropad V.Yu.,Medical Radiological Scientific Center | Berdov B.A.,Medical Radiological Scientific Center | Rukhadze G.O.,Medical Radiological Scientific Center
Voprosy Onkologii

There were analyzed patterns of polyneoplasia development in radically operated gastric cancer patients. The second tumors were revealed in 99 of 1255 patients (7,9%) as soon as patients with early gastric cancer manifested primary-multiple malignant tumors almost two times more (15,4%). Among second tumors there were predominantly tumors of the colon, urinogenital system, head and neck and also lymphoproliferative diseases. Along with tumors prior to the diagnosis "gastric cancer" there were met mostly lymphoproliferative diseases and breast cancer; of synchronous - cancer of the colon and bladder; among exposed after treatment of gastric cancer - cancer of the colon, pancreas, and skin. Radical surgery because of the second tumor was provided to 77,6% patients, palliative surgery - to 12,6%. In the treatment of second tumors there were most commonly used surgical technique - in 40 (39%) patients, radiotherapy ± chemotherapy - in 27 (26%), the combined method (surgery+radiotherapy/ chemotherapy) - in 22 (21%). Second tumors (both synchronous and metachronous) were the main cause of death of patients. Thus, the occurrence of a second tumor in patients with gastric cancer is constantly increasing the frequency of the event, with the possibility of early detection and curative treatment of synchronous and especially metachronous tumors determine the prognosis in this group of patients. Primary tumor multiplicity is not a contraindication both to a radical, including combined, and palliative treatment of each of the tumors. Source

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