Konoplyannikov A.G.,Medical Radiological Research CentreBranch of the National Medical Radiological Research Center |
Alekseenskiy A.E.,RAS Ioffe Physical - Technical Institute |
Zlotin S.G.,RAS Institute of Organic Chemistry |
Smirnov B.B.,RAS Institute of Organic Chemistry |
And 7 more authors.
Crystallography Reports | Year: 2015
Combined use of complexes of the most active chemotherapeutic drugs and detonation nanodiamonds (DND) is a new trend in cancer therapy, which is probably related to selective chemotherapeutic drug delivery by DND to the zone of so-called cancer stem cells (CSC). Stable DND complexes of 4–5 nm size with salinomycin—a strong CSC inhibitor—have been obtained (as a suspension). It has been demonstrated that a complex administration considerably increases the drug antitumor effect on the transplantable tumor of LLC mice. A similar effect has been observed in CSC models in vivo, obtained by exposure of stem cells of normal mice tissues to a carcinogen 1,2-dimethylhydrazine. It has also been found out, that administration of DND complexes with the conditioned medium from mesenchymal stem cells (MSC) cultures to mice results in a considerable stimulation of stem cell pools in normal mice tissues, which can be used in regenerative medicine. © 2015, Pleiades Publishing, Inc.