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Shari M. Ling, MD has been selected to receive the first-ever Public Service Award from NKF, established to honor those who have dedicated their careers to public service and who have helped to shape public policies or government programs that improve outcomes for kidney patients.  Dr. Ling currently serves as the Deputy Chief Medical Officer for the Centers for Medicare and Medicaid Services (CMS) and Medical Officer in the Center for Clinical Standards and Quality (CCSQ).  In her role at CMS, she assists the CMS Chief Medical Officer in the agency's pursuit of better health care, healthier populations and smarter spending. Dr. Ling's committed focus is on the achievement of meaningful health outcomes for patients and families through the delivery of high quality, person-centered care, across all care settings. Her clinical focus and scientific interest is in the care of persons with dementia, multiple chronic conditions and functional limitations. Derek Forfang, a kidney patient and long-time kidney disease advocate, has been selected to receive the first-ever Celeste Castillo Lee Patient Engagement Award, established in honor of Celeste Castillo Lee, a longtime advocate for patient-centered care and empowerment. It is the highest honor given by NKF to a distinguished kidney patient who exemplifies NKF's mission and Celeste's legacy of putting patients at the center of all aspects of healthcare through their involvement with NKF and community partners.  Mr. Forfang, of San Pablo, California, has been an end-stage renal disease (ESRD) patient since 1999.  He received a kidney transplant and has also been on peritoneal dialysis and hemodialysis.  A regional leader of NKF's Kidney Advocacy Committee and a member of the Public Policy Committee, Derek has worked tirelessly to protect and improve care for the kidney community. Merck been selected to receive the 2017 Corporate Innovator Award which recognizes industry partners that advance the field of nephrology by addressing an unmet medical need, or improving upon an existing practice, therapeutic or technology.  Merck's innovative new treatment for hepatitis C, ZEPATIER, is the only direct anti-viral agent specifically tested and approved for use in patients with chronic kidney disease stages four and five. Paul Palevsky, MD has been selected to receive the Dr. J. Michael Lazarus Distinguished Award established to honor Dr. Lazarus for his major contributions to the clinical science and care of dialysis patients, and to recognize individuals whose research has yielded novel insights related to renal replacement therapy.  Dr. Palevsky is Professor of Medicine and Clinical and Translational Science in the Renal-Electrolyte Division at the University of Pittsburgh School of Medicine; and serves as Chief of the Renal Section at the VA Pittsburgh Healthcare System.  Dr. Palevsky's research has primarily focused on acute kidney injury and critical care nephrology. He will be presenting the Lazarus lecture on "We Don't Have to Fail at Acute Renal Failure: A Multidisciplinary Approach to Quality Improvement" on Friday, April 21st at 8:45 a.m. at the NKF Spring Clinical Meetings. Susanne Nicholas, MD, MPH, PhD has been selected to receive the Medical Advisory Board Distinguished Service Award established to recognize an individual for their educational activities and community service in promoting the mission of NKF on a local level.  Dr. Nicholas is a tenured Associate Professor of Medicine at UCLA in the Division of Nephrology where she maintains her clinical responsibilities, and the Division of Endocrinology, Diabetes and Hypertension, where she conducts research.  She is also a Clinical Hypertension Specialist.   Dr. Nicholas' research interests include understanding and identifying key factors that promote the pathogenesis of diabetic kidney disease (DKD); uncovering and validating novel biomarkers that may predict DKD progression; and quantifying renal structural changes associated with DKD in response to novel therapeutics, using stereology principles. Her research over the past 15 years has led to the identification of a novel biomarker of DKD, which is currently being validated in clinical studies. Katherine R. Tuttle, MD, FASN, FACP, FNKF, has been selected to receive the prestigious Garabed Eknoyan Award, created to recognize an individual who has promoted the mission of NKF in Making Lives Better for people with kidney disease through the exceptional contributions to key initiatives of NKF such as the Kidney Disease Outcomes Quality Initiative (KDOQI) or clinical research in the field of kidney disease.  Dr. Tuttle is the Executive Director for Research at Providence Health Care in Spokane, and serves as Co-Principal Investigator of the Institute of Translational Health Sciences, Investigator at Kidney Research Institute, and Clinical Professor of Medicine for the University of Washington.  Dr. Tuttle's major research interests include diabetic kidney disease, hypertension, renal vascular disease, nutrition in chronic kidney disease, and transitional care.  She has chaired numerous workgroups focused on diabetes and kidney disease including NKF's KDOQI Workgroup for Diabetes and Chronic Kidney Disease. Jonathan Himmelfarb, MD has been selected to receive the Donald W. Seldin Award, established to recognize excellence in clinical nephrology in the tradition of one of the foremost teachers and researchers in the field, Dr. Donald W. Seldin.  Dr. Himmelfarb is a Professor of Medicine, Director of the Kidney Research Institute, and holds the Joseph W. Eschbach, M.D. Endowed Chair in Kidney Research at the University of Washington School of Medicine.   He is the author of more than 200 peer-reviewed publications, has served on numerous grant review committees and scientific advisory boards and has held leadership positions in many national and international nephrology societies.  Dr. Himmelfarb has served on expert panels for the U.S. Food and Drug Administration, Veterans Health Administration, and Centers for Medicare & Medicaid Services. He is also a nephrologist who cares for patients with kidney disease, and an internationally recognized educator about kidney disease. Raymond R. Townsend, MD has been selected to receive the Shaul G. Massry Distinguished Lecture Award, established to honor Dr. Massry for his scientific achievements and contribution to the kidney health care community and to NKF.  Dr. Townsend is Professor of Medicine and an Associate Director of the Center for Human Phenomic Studies at the University of Pennsylvania.  He is currently a Principal Investigator evaluating the role of demographic, phenotypic, humoral and genetic factors in the progression of kidney disease and the development and progression of cardiovascular disease in patients with chronic kidney disease.  He was also the Principal Investigator of a multicenter effort evaluating the specific role of pulse wave velocity in the renal and cardiovascular consequences of chronic kidney disease.   Dr. Townsend led the work group that wrote the KDOQI Commentary on the 2012 KDIGO Guideline on this subject, and most recently co-chaired the NKF workshop on Potassium Homeostasis in Disease and Health, the report on which will soon be published in the American Journal of Kidney Disease and Journal of the American Society of Hypertension. Tilakavati Karupaiah, PhD, APD, AN has been selected to receive the Joel D. Kopple Award, an annual award honoring an individual who has made significant contributions to the field of renal nutrition.  Dr. Karupaiah is an Accredited Practicing Dietitian with Dietitian's Association of Australia, a Professor and Head of the Dietetics Program at the National University of Malaysia; and also Adjunct Associate Professor at Wayne State University, Detroit.    Dr. Karupaiah's involvement in renal nutrition began because of a lack of dietitians in this field in Malaysia, and dialysis patients needed patient-friendly information about local diets. At the National University of Malaysia, she encouraged early exposure of dietetic students to renal patient care through community engagement, outpatient counseling and practical skills on patient diet planning. Dr. Karupaiah is now targeting capacity building mentorship for developing renal dietitians in Malaysia through nutrition research. For the past 26 years, nephrology healthcare professionals from across the country have come to NKF's Spring Clinical Meetings to learn about the newest developments related to all aspects of nephrology practice, network with colleagues, and present their research findings. The NKF Spring Clinical Meetings are designed for meaningful change in the multidisciplinary healthcare teams' skills, performance, and patient health outcomes.  It is the only conference of its kind that focuses on translating science into practice for the entire healthcare team. 1 in 3 American adults is at risk for kidney disease.  26 million American adults have kidney disease—and most aren't aware of it.  Risk factors for kidney disease include diabetes, high blood pressure, family history, and age 60+.  People of African American; Hispanic; Native American; Asian; or Pacific Islander descent are at increased risk for developing the disease.  African Americans are 3 ½ times more likely, and Hispanics 1 ½ times more likely, to experience kidney failure. The National Kidney Foundation (NKF) is the largest, most comprehensive and longstanding organization dedicated to the awareness, prevention and treatment of kidney disease.  For more information about NKF visit www.kidney.org. :  Full press releases on each award recipient, including quotes for attribution, are hyperlinked by recipient's name and can also be found in the Newsroom at www.kidney.org. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/national-kidney-foundation-honors-leading-researchers-clinicians-patient-advocates-and-more-at-its-26th-annual-spring-clinical-meetings-300442333.html


NEW YORK, May 08, 2017 (GLOBE NEWSWIRE) -- BeyondSpring Inc. (NASDAQ:BYSI), a global clinical stage biopharmaceutical company focused on the development of innovative cancer therapies, announced today that the Company’s Chief Medical Officer and Head of Business Development, Dr. Ramon Mohanlal, M.D., Ph.D., M.B.A., will present at the Evolution Summit in Miami, Chief Medical Officer Summit in Boston and Clinical Leader Forum in Philadelphia on May 8, 10 and 11, 2017, respectively. Dr. Mohanlal will discuss the “Progression of Immunotherapy and its Impact on Cancer Research” as part of his presentation at the Evolution Summit at 5:15 p.m. ET at the Ritz-Carlton Coconut Grove, as well as join a panel on “Assessing and Creating Value and the Impact of Pricing Trends on R&D Strategies” at the Chief Medical Officer Summit at 9:30 a.m. ET at the Colonnade Hotel. Finally, Dr. Mohanlal will present on the importance of “Payer Perspective, Market Access and Patient Reported Outcomes” at this year’s Clinical Leader Forum at 3:15 p.m. ET at the Hilton Philadelphia City Avenue. “It is an honor to speak at each of these prestigious conferences and present alongside some of the most exemplary leaders and pioneers in the healthcare and medical industry, opening up the dialogue around important topics that affect biopharma professionals everywhere,” said Dr. Mohanlal. “At BeyondSpring, these conversations are essential when it comes to continuing our work and growing our partnerships with other pharmaceutical professionals who have deep industry knowledge of the oncology space. Our team looks forward to capitalizing on these opportunities to help advance our lead asset, Plinabulin, which is in a Phase 3 trial as a direct anticancer agent in non-small cell lung cancer and Phase 2/3 trial for neutropenia prevention, to build toward its commercial success.” Plinabulin, a novel small molecule that alters the tumor micro-environment and stimulates dendritic cell maturation and T-cell activation, has produced encouraging data regarding the mitigation of severe neutropenia, a common and potentially life-threatening adverse effect of Docetaxel. Plinabulin can be administered one hour after chemotherapy and has the potential to be a safe, cost-effective and convenient alternative with much less bone pain than G-CSF, the current standard of care for chemotherapy-induced neutropenia. Plinabulin offers a same-day dosing advantage over G-CSF, which should be administered 24 hours after chemotherapy, per G-CSF label (next-day dosing), by which time significant damage to neutrophils has occurred. Additionally, Plinabulin has demonstrated a reduction in clinical sequelae associated with Docetaxel-induced neutropenia, including infections, sepsis, hospitalizations and the need for Docetaxel dose reductions. The Evolution Summit is a forum that brings together leading drug development executives and solution providers, with the goal of providing an intimate environment in which attendees can take part in a focused discussion on key new drivers that are shaping drug development. The Chief Medical Officer Summit is an annual gathering of physicians where they exchange best practices in the advancement of drug development within the confines of the emerging biotech space. The Clinical Leader Forum is an event that’s focused on sponsor-CRO partnerships and issues that matter most to executives at small and midsize sponsor companies. About BeyondSpring BeyondSpring is a global clinical stage biopharmaceutical company developing innovative immuno-oncology cancer therapies with a robust pipeline from internal development and from collaboration with Fred Hutchinson Cancer Research Center and University of Washington. BeyondSpring’s lead asset, Plinabulin, is in a Phase 3 clinical trial as a direct anticancer agent in non-small cell lung cancer and a Phase 2/3 clinical trial in the prevention of chemotherapy-induced neutropenia. BeyondSpring has a seasoned management team with many years of experience bringing drugs to market. About Plinabulin Studies on Plinabulin's method of action indicate that Plinabulin activates GEF-H1, a guanine nucleotide exchange factor. GEF-H1 activates downstream transduction pathways leading to the activation of the protein c-Jun. Activated c-Jun enters the nucleus of dendritic cells to upregulate immune-related genes, which contributes to the up-regulation of a series of genes leading to dendritic cell maturation, T-cell activation and other effects that prevent neutropenia. Cautionary Note Regarding Forward-Looking Statements This press release includes forward-looking statements that are not historical facts. Words such as "will," "expect," "anticipate," "plan," "believe," "design," "may," "future," "estimate," "predict," "objective," "goal," or variations thereof and variations of such words and similar expressions are intended to identify such forward-looking statements. Forward-looking statements are based on BeyondSpring's current knowledge and its present beliefs and expectations regarding possible future events and are subject to risks, uncertainties and assumptions. Actual results and the timing of events could differ materially from those anticipated in these forward-looking statements as a result of several factors including, but not limited to, the anticipated amount needed to finance the company's future operations, unexpected results of clinical trials, delays or denial in regulatory approval process, our expectations regarding the potential safety, efficacy or clinical utility of our product candidates, or additional competition in the market. The forward-looking statements made herein speak only as of the date of this release and BeyondSpring undertakes no obligation to update publicly such forward-looking statements to reflect subsequent events or circumstances, except as otherwise required by law.


NEW YORK, May 08, 2017 (GLOBE NEWSWIRE) -- BeyondSpring Inc. (NASDAQ:BYSI), a global clinical stage biopharmaceutical company focused on the development of innovative cancer therapies, announced today that the Company’s Chief Medical Officer and Head of Business Development, Dr. Ramon Mohanlal, M.D., Ph.D., M.B.A., will present at the Evolution Summit in Miami, Chief Medical Officer Summit in Boston and Clinical Leader Forum in Philadelphia on May 8, 10 and 11, 2017, respectively. Dr. Mohanlal will discuss the “Progression of Immunotherapy and its Impact on Cancer Research” as part of his presentation at the Evolution Summit at 5:15 p.m. ET at the Ritz-Carlton Coconut Grove, as well as join a panel on “Assessing and Creating Value and the Impact of Pricing Trends on R&D Strategies” at the Chief Medical Officer Summit at 9:30 a.m. ET at the Colonnade Hotel. Finally, Dr. Mohanlal will present on the importance of “Payer Perspective, Market Access and Patient Reported Outcomes” at this year’s Clinical Leader Forum at 3:15 p.m. ET at the Hilton Philadelphia City Avenue. “It is an honor to speak at each of these prestigious conferences and present alongside some of the most exemplary leaders and pioneers in the healthcare and medical industry, opening up the dialogue around important topics that affect biopharma professionals everywhere,” said Dr. Mohanlal. “At BeyondSpring, these conversations are essential when it comes to continuing our work and growing our partnerships with other pharmaceutical professionals who have deep industry knowledge of the oncology space. Our team looks forward to capitalizing on these opportunities to help advance our lead asset, Plinabulin, which is in a Phase 3 trial as a direct anticancer agent in non-small cell lung cancer and Phase 2/3 trial for neutropenia prevention, to build toward its commercial success.” Plinabulin, a novel small molecule that alters the tumor micro-environment and stimulates dendritic cell maturation and T-cell activation, has produced encouraging data regarding the mitigation of severe neutropenia, a common and potentially life-threatening adverse effect of Docetaxel. Plinabulin can be administered one hour after chemotherapy and has the potential to be a safe, cost-effective and convenient alternative with much less bone pain than G-CSF, the current standard of care for chemotherapy-induced neutropenia. Plinabulin offers a same-day dosing advantage over G-CSF, which should be administered 24 hours after chemotherapy, per G-CSF label (next-day dosing), by which time significant damage to neutrophils has occurred. Additionally, Plinabulin has demonstrated a reduction in clinical sequelae associated with Docetaxel-induced neutropenia, including infections, sepsis, hospitalizations and the need for Docetaxel dose reductions. The Evolution Summit is a forum that brings together leading drug development executives and solution providers, with the goal of providing an intimate environment in which attendees can take part in a focused discussion on key new drivers that are shaping drug development. The Chief Medical Officer Summit is an annual gathering of physicians where they exchange best practices in the advancement of drug development within the confines of the emerging biotech space. The Clinical Leader Forum is an event that’s focused on sponsor-CRO partnerships and issues that matter most to executives at small and midsize sponsor companies. About BeyondSpring BeyondSpring is a global clinical stage biopharmaceutical company developing innovative immuno-oncology cancer therapies with a robust pipeline from internal development and from collaboration with Fred Hutchinson Cancer Research Center and University of Washington. BeyondSpring’s lead asset, Plinabulin, is in a Phase 3 clinical trial as a direct anticancer agent in non-small cell lung cancer and a Phase 2/3 clinical trial in the prevention of chemotherapy-induced neutropenia. BeyondSpring has a seasoned management team with many years of experience bringing drugs to market. About Plinabulin Studies on Plinabulin's method of action indicate that Plinabulin activates GEF-H1, a guanine nucleotide exchange factor. GEF-H1 activates downstream transduction pathways leading to the activation of the protein c-Jun. Activated c-Jun enters the nucleus of dendritic cells to upregulate immune-related genes, which contributes to the up-regulation of a series of genes leading to dendritic cell maturation, T-cell activation and other effects that prevent neutropenia. Cautionary Note Regarding Forward-Looking Statements This press release includes forward-looking statements that are not historical facts. Words such as "will," "expect," "anticipate," "plan," "believe," "design," "may," "future," "estimate," "predict," "objective," "goal," or variations thereof and variations of such words and similar expressions are intended to identify such forward-looking statements. Forward-looking statements are based on BeyondSpring's current knowledge and its present beliefs and expectations regarding possible future events and are subject to risks, uncertainties and assumptions. Actual results and the timing of events could differ materially from those anticipated in these forward-looking statements as a result of several factors including, but not limited to, the anticipated amount needed to finance the company's future operations, unexpected results of clinical trials, delays or denial in regulatory approval process, our expectations regarding the potential safety, efficacy or clinical utility of our product candidates, or additional competition in the market. The forward-looking statements made herein speak only as of the date of this release and BeyondSpring undertakes no obligation to update publicly such forward-looking statements to reflect subsequent events or circumstances, except as otherwise required by law.


NEW YORK, May 08, 2017 (GLOBE NEWSWIRE) -- BeyondSpring Inc. (NASDAQ:BYSI), a global clinical stage biopharmaceutical company focused on the development of innovative cancer therapies, announced today that the Company’s Chief Medical Officer and Head of Business Development, Dr. Ramon Mohanlal, M.D., Ph.D., M.B.A., will present at the Evolution Summit in Miami, Chief Medical Officer Summit in Boston and Clinical Leader Forum in Philadelphia on May 8, 10 and 11, 2017, respectively. Dr. Mohanlal will discuss the “Progression of Immunotherapy and its Impact on Cancer Research” as part of his presentation at the Evolution Summit at 5:15 p.m. ET at the Ritz-Carlton Coconut Grove, as well as join a panel on “Assessing and Creating Value and the Impact of Pricing Trends on R&D Strategies” at the Chief Medical Officer Summit at 9:30 a.m. ET at the Colonnade Hotel. Finally, Dr. Mohanlal will present on the importance of “Payer Perspective, Market Access and Patient Reported Outcomes” at this year’s Clinical Leader Forum at 3:15 p.m. ET at the Hilton Philadelphia City Avenue. “It is an honor to speak at each of these prestigious conferences and present alongside some of the most exemplary leaders and pioneers in the healthcare and medical industry, opening up the dialogue around important topics that affect biopharma professionals everywhere,” said Dr. Mohanlal. “At BeyondSpring, these conversations are essential when it comes to continuing our work and growing our partnerships with other pharmaceutical professionals who have deep industry knowledge of the oncology space. Our team looks forward to capitalizing on these opportunities to help advance our lead asset, Plinabulin, which is in a Phase 3 trial as a direct anticancer agent in non-small cell lung cancer and Phase 2/3 trial for neutropenia prevention, to build toward its commercial success.” Plinabulin, a novel small molecule that alters the tumor micro-environment and stimulates dendritic cell maturation and T-cell activation, has produced encouraging data regarding the mitigation of severe neutropenia, a common and potentially life-threatening adverse effect of Docetaxel. Plinabulin can be administered one hour after chemotherapy and has the potential to be a safe, cost-effective and convenient alternative with much less bone pain than G-CSF, the current standard of care for chemotherapy-induced neutropenia. Plinabulin offers a same-day dosing advantage over G-CSF, which should be administered 24 hours after chemotherapy, per G-CSF label (next-day dosing), by which time significant damage to neutrophils has occurred. Additionally, Plinabulin has demonstrated a reduction in clinical sequelae associated with Docetaxel-induced neutropenia, including infections, sepsis, hospitalizations and the need for Docetaxel dose reductions. The Evolution Summit is a forum that brings together leading drug development executives and solution providers, with the goal of providing an intimate environment in which attendees can take part in a focused discussion on key new drivers that are shaping drug development. The Chief Medical Officer Summit is an annual gathering of physicians where they exchange best practices in the advancement of drug development within the confines of the emerging biotech space. The Clinical Leader Forum is an event that’s focused on sponsor-CRO partnerships and issues that matter most to executives at small and midsize sponsor companies. About BeyondSpring BeyondSpring is a global clinical stage biopharmaceutical company developing innovative immuno-oncology cancer therapies with a robust pipeline from internal development and from collaboration with Fred Hutchinson Cancer Research Center and University of Washington. BeyondSpring’s lead asset, Plinabulin, is in a Phase 3 clinical trial as a direct anticancer agent in non-small cell lung cancer and a Phase 2/3 clinical trial in the prevention of chemotherapy-induced neutropenia. BeyondSpring has a seasoned management team with many years of experience bringing drugs to market. About Plinabulin Studies on Plinabulin's method of action indicate that Plinabulin activates GEF-H1, a guanine nucleotide exchange factor. GEF-H1 activates downstream transduction pathways leading to the activation of the protein c-Jun. Activated c-Jun enters the nucleus of dendritic cells to upregulate immune-related genes, which contributes to the up-regulation of a series of genes leading to dendritic cell maturation, T-cell activation and other effects that prevent neutropenia. Cautionary Note Regarding Forward-Looking Statements This press release includes forward-looking statements that are not historical facts. Words such as "will," "expect," "anticipate," "plan," "believe," "design," "may," "future," "estimate," "predict," "objective," "goal," or variations thereof and variations of such words and similar expressions are intended to identify such forward-looking statements. Forward-looking statements are based on BeyondSpring's current knowledge and its present beliefs and expectations regarding possible future events and are subject to risks, uncertainties and assumptions. Actual results and the timing of events could differ materially from those anticipated in these forward-looking statements as a result of several factors including, but not limited to, the anticipated amount needed to finance the company's future operations, unexpected results of clinical trials, delays or denial in regulatory approval process, our expectations regarding the potential safety, efficacy or clinical utility of our product candidates, or additional competition in the market. The forward-looking statements made herein speak only as of the date of this release and BeyondSpring undertakes no obligation to update publicly such forward-looking statements to reflect subsequent events or circumstances, except as otherwise required by law.


NEW YORK, May 08, 2017 (GLOBE NEWSWIRE) -- BeyondSpring Inc. (NASDAQ:BYSI), a global clinical stage biopharmaceutical company focused on the development of innovative cancer therapies, announced today that the Company’s Chief Medical Officer and Head of Business Development, Dr. Ramon Mohanlal, M.D., Ph.D., M.B.A., will present at the Evolution Summit in Miami, Chief Medical Officer Summit in Boston and Clinical Leader Forum in Philadelphia on May 8, 10 and 11, 2017, respectively. Dr. Mohanlal will discuss the “Progression of Immunotherapy and its Impact on Cancer Research” as part of his presentation at the Evolution Summit at 5:15 p.m. ET at the Ritz-Carlton Coconut Grove, as well as join a panel on “Assessing and Creating Value and the Impact of Pricing Trends on R&D Strategies” at the Chief Medical Officer Summit at 9:30 a.m. ET at the Colonnade Hotel. Finally, Dr. Mohanlal will present on the importance of “Payer Perspective, Market Access and Patient Reported Outcomes” at this year’s Clinical Leader Forum at 3:15 p.m. ET at the Hilton Philadelphia City Avenue. “It is an honor to speak at each of these prestigious conferences and present alongside some of the most exemplary leaders and pioneers in the healthcare and medical industry, opening up the dialogue around important topics that affect biopharma professionals everywhere,” said Dr. Mohanlal. “At BeyondSpring, these conversations are essential when it comes to continuing our work and growing our partnerships with other pharmaceutical professionals who have deep industry knowledge of the oncology space. Our team looks forward to capitalizing on these opportunities to help advance our lead asset, Plinabulin, which is in a Phase 3 trial as a direct anticancer agent in non-small cell lung cancer and Phase 2/3 trial for neutropenia prevention, to build toward its commercial success.” Plinabulin, a novel small molecule that alters the tumor micro-environment and stimulates dendritic cell maturation and T-cell activation, has produced encouraging data regarding the mitigation of severe neutropenia, a common and potentially life-threatening adverse effect of Docetaxel. Plinabulin can be administered one hour after chemotherapy and has the potential to be a safe, cost-effective and convenient alternative with much less bone pain than G-CSF, the current standard of care for chemotherapy-induced neutropenia. Plinabulin offers a same-day dosing advantage over G-CSF, which should be administered 24 hours after chemotherapy, per G-CSF label (next-day dosing), by which time significant damage to neutrophils has occurred. Additionally, Plinabulin has demonstrated a reduction in clinical sequelae associated with Docetaxel-induced neutropenia, including infections, sepsis, hospitalizations and the need for Docetaxel dose reductions. The Evolution Summit is a forum that brings together leading drug development executives and solution providers, with the goal of providing an intimate environment in which attendees can take part in a focused discussion on key new drivers that are shaping drug development. The Chief Medical Officer Summit is an annual gathering of physicians where they exchange best practices in the advancement of drug development within the confines of the emerging biotech space. The Clinical Leader Forum is an event that’s focused on sponsor-CRO partnerships and issues that matter most to executives at small and midsize sponsor companies. About BeyondSpring BeyondSpring is a global clinical stage biopharmaceutical company developing innovative immuno-oncology cancer therapies with a robust pipeline from internal development and from collaboration with Fred Hutchinson Cancer Research Center and University of Washington. BeyondSpring’s lead asset, Plinabulin, is in a Phase 3 clinical trial as a direct anticancer agent in non-small cell lung cancer and a Phase 2/3 clinical trial in the prevention of chemotherapy-induced neutropenia. BeyondSpring has a seasoned management team with many years of experience bringing drugs to market. About Plinabulin Studies on Plinabulin's method of action indicate that Plinabulin activates GEF-H1, a guanine nucleotide exchange factor. GEF-H1 activates downstream transduction pathways leading to the activation of the protein c-Jun. Activated c-Jun enters the nucleus of dendritic cells to upregulate immune-related genes, which contributes to the up-regulation of a series of genes leading to dendritic cell maturation, T-cell activation and other effects that prevent neutropenia. Cautionary Note Regarding Forward-Looking Statements This press release includes forward-looking statements that are not historical facts. Words such as "will," "expect," "anticipate," "plan," "believe," "design," "may," "future," "estimate," "predict," "objective," "goal," or variations thereof and variations of such words and similar expressions are intended to identify such forward-looking statements. Forward-looking statements are based on BeyondSpring's current knowledge and its present beliefs and expectations regarding possible future events and are subject to risks, uncertainties and assumptions. Actual results and the timing of events could differ materially from those anticipated in these forward-looking statements as a result of several factors including, but not limited to, the anticipated amount needed to finance the company's future operations, unexpected results of clinical trials, delays or denial in regulatory approval process, our expectations regarding the potential safety, efficacy or clinical utility of our product candidates, or additional competition in the market. The forward-looking statements made herein speak only as of the date of this release and BeyondSpring undertakes no obligation to update publicly such forward-looking statements to reflect subsequent events or circumstances, except as otherwise required by law.


News Article | April 26, 2017
Site: news.yahoo.com

GENEVA (Reuters) - Liberian health authorities are taking rapid precautionary steps after eight people died of a mystery illness, the World Health Organization said on Wednesday, 10 months after the end of a catastrophic two-year Ebola virus outbreak. Liberian authorities said initial scientific investigations ruled out Ebola as the cause of the deaths. "Yesterday WHO received a report from Liberia health authorities about a cluster of unexplained illness and deaths in the southern part of the country – Sinoe County," WHO spokesman Tarik Jasarevic said in emailed comments. "According to this report, since Monday 14 people have fallen sick. Eight people have died and six are seriously ill and still in the hospital." He gave no indication of what might have caused the deaths but said specimens from seven bodies had been sent to the national laboratory for testing. Results are expected later on Wednesday or Thursday. Samples were also being taken from water sources to test for chemicals and bacteria. "Health authorities are taking immediate precautionary measures such as isolating suspect cases, tracing contacts and engaging with the community and their leaders," Jasarevic said. Rapid response teams have been activated at district and county level, he said. The Chief Medical Officer of Liberia, Dr. Francis Kateh, told a news conference in Monrovia on Wednesday: "Initial test conducted by the Liberian Institute of Biomedical Research in Charlesville, Margibi County, has ruled out Ebola virus disease as the cause of the deaths." In June last year, the WHO declared Liberia free of active Ebola virus transmission, the last of three West African countries at the epicenter of the world's worst outbreak of the disease. The epidemic killed more than 11,300 people and infected some 28,600 from 2013, as it swept through Guinea, Sierra Leone and Liberia, according to WHO data.


News Article | February 22, 2017
Site: www.prweb.com

NDA Partners Chairman Carl Peck, MD, announced today that Dr. Daniel Spyker, PhD, MD former Acting Deputy Director in the FDA CDRH Division of Cardiovascular, Respiratory, and Neurological Devices and Medical Officer in CDER’s Pilot Drug Evaluation Staff has joined the company as an Expert Consultant. In Dr. Spyker’s accomplished career, he held positions as Senior Director of Drug Safety and Pharmacovigilance at Alexza Pharmaceuticals; Director, Pharmacokinetics and Pharmacodynamic Sciences, Genentech, where he established the clinical pharmacology unit; and Senior Medical Director, Clinical Risk Assessment and Coordination Department at Purdue Pharma. Dr. Spyker was a member of the Internal Medicine faculty in the Division of Clinical Pharmacology at the University of Virginia for 10 years, where he fostered and nurtured the Blue Ridge Poison Center. He was also founder and CEO of a software company specializing in poison center data collection and Bayesian pharmacokinetic applications. “Dr. Daniel Spkyer’s knowledge and expertise of cardiovascular, respiratory, and neurological devices at FDA and in the Industry, in addition to his expertise in quantitative clinical pharmacology and toxicology, make him an excellent addition to NDA Partners. He will bring great value to our medical device clients and we are very pleased to welcome him,” said Dr. Feigal, who heads NDA Partners’ Medical Device Practice. Dr. Spyker earned his PhD from the University of Minnesota in Electrical Engineering and Mathematics, his MD from the University of Virginia, and MS from Purdue University. He is board certified in Internal Medicine, a diplomate of the American Board of Medical Toxicology, and diplomate of the American Board of Clinical Pharmacology. About NDA Partners NDA Partners is a strategy consulting firm specializing in expert product development and regulatory advice to the medical products industry and associated service industries such as law firms, investment funds and government research agencies. The highly experienced Principals and Premier Experts of NDA Partners include three former FDA Center Directors; the former Chairman of the Medicines and Healthcare Products Regulatory Agency (MHRA) in the UK; an international team of more than 100 former pharmaceutical industry and regulatory agency senior executives; and an extensive roster of highly proficient experts in specialized areas including nonclinical development, toxicology, pharmacokinetics, CMC, medical device design control and quality systems, clinical development, regulatory submissions, and development program management. Services include product development and regulatory strategy, expert consulting, high-impact project teams, and virtual product development teams.


News Article | December 12, 2016
Site: www.prweb.com

Gateway Foundation, Illinois leading non-profit provider of addiction treatment services today announced the appointment of Roueen Rafeyan M.D. as Chief Medical Officer (CMO). This position is integral to supporting the company’s strategic growth and fulfilling its mission to provide state of the art care to individuals and families. Dr. Rafeyan brings over 20 years of specialized experience to Gateway, having served as a medical director for psychiatric and substance use programs at leading Illinois healthcare institutions including Rush, Michael Reese, Resurrection and Presence Behavioral Health. As CMO, Dr. Rafeyan is responsible for continuously advancing Gateway’s wide array of services including Medication Assisted Treatment. He works closely with Gateway’s team of experienced physicians and clinicians to deliver comprehensive high quality addictions, psychiatric and medical services and treatment as needed for each individual. Dr. Rafeyan’s treatment philosophy includes providing a comprehensive assessment of medical and psychiatric comorbidities to render better outcomes, and a core belief that the disease of addiction goes beyond the individual and affects the entire family. Professional support and education of the family is as important as treating the individual. “We are excited to be the first Illinois rehabilitation facility to introduce the addition of a Chief Medical Officer to our team,” stated Dr. Thomas Britton, Gateway’s CEO. “Dr. Rafeyan is exactly the type of leader that can help us continue to make a real difference in the lives of those we treat.” In addition to Dr. Rafeyan’s extensive medical experience, he is also a diplomat of the American Board of Psychiatry and Neurology as well as the American Society of Addiction Medicine. He is currently on the faculty of Northwestern University and an active member of the American Medical Association, the American Psychiatry Association, the Illinois Psychiatric Society and Illinois State Medical Society. Since 1968 our goal has been straightforward: to help clients get their life back on track and achieve a life of sobriety, free from drug use and symptoms of mental illness, that is productive, socially responsible, and healthy. Gateway Foundation is the largest nonprofit treatment provider in the country that specializes in the treatment of substance use disorders, providing treatment for men, women, adolescents, and clients diagnosed with co-occurring mental health disorders. Gateway’s Community Division has treatment centers located throughout Illinois, including Carbondale, Chicago, Lake County, Fox Valley, Springfield, and the St. Louis Metro East area. These centers offer residential and outpatient treatment services for adults, teens, and adolescents accessed through insurance, state funding, and self-pay. Gateway’s professional clinicians help thousands of individuals successfully complete treatment by developing a personalized plan that treats the underlying causes of substance abuse—not just addiction to drugs or alcohol. Learn more about insurance coverage, treatment options, or Gateway's confidential consultation at RecoverGateway.org or call 877-505-HOPE (4673). Reporters and Editors, for more information, please call Leslie Colman, Marketing Director, at 630-776-5725.


KENILWORTH, N.J.--(BUSINESS WIRE)--Many adults with diabetes are unaware of their increased risk for certain serious illnesses, including pneumococcal pneumonia/pneumococcal disease, flu and hepatitis B. This is according to a recent national, online consumer awareness survey sponsored by Merck (NYSE:MRK), known as MSD outside the United States and Canada, and the American Diabetes Association, and conducted by Harris Poll. In the survey of 1,003 U.S. adults ages 18 years and older diagnosed with diabetes, respondents were twice as likely to recognize the potential for adults with diabetes to develop kidney disease (72%) and heart disease (67%), than serious infectious diseases such as pneumococcal disease, including pneumonia, meningitis, or an infection of the blood (36%), compared to adults without diabetes. While published data1 show that adults with diabetes are approximately three times more likely to develop pneumococcal disease compared to healthy adults of the same age, only about 1 in 3 survey respondents (35%) believed they were at least somewhat personally likely to get pneumococcal pneumonia/pneumococcal disease. In addition, less than half of those surveyed (43%) responded that they had discussed the risk factors for pneumococcal pneumonia/pneumococcal disease with their doctor. “ These data illustrate that patients with diabetes are not fully aware of their risk of other serious illnesses, and that there is a critical communication gap between patients and their health care providers about the risks for serious illness, including pneumococcal pneumonia or pneumococcal disease, flu and hepatitis B for adults with diabetes. Because people with diabetes have increased risks for these diseases and more complicated medical courses when they contract them, health care providers should seek to initiate discussions with patients to bridge the information gap, as recommended in our Standards of Care,” said American Diabetes Association Immediate Past Chief Scientific & Medical Officer Robert E. Ratner, M.D. In the 2016 Standards of Medical Care in Diabetes, the American Diabetes Association states: “ Ongoing patient self-management education and support are critical to preventing acute complications, and reducing the risk of long-term complications.” The Standards of Care also recognize and emphasize the importance of patient-centered engagement and communication to the foundation of diabetes care. Indeed, thirty-five percent of the survey respondents strongly/somewhat agreed with the statement: “ I wish I knew more about pneumococcal pneumonia or pneumococcal disease,” and eighty-five percent believed that pneumococcal pneumonia/pneumococcal disease is a very/somewhat serious health condition for adults with diabetes. “ This lack of awareness is significant—based on the survey, we know that adults with diabetes wish they knew more about certain diseases for which they are at risk, including pneumococcal pneumonia or pneumococcal disease,” said Mel Kohn, M.D., MPH, medical director, Merck. In March of 2015, Merck and the American Diabetes Association announced a collaboration aiming to educate adults with diabetes about their increased risk for certain serious illnesses, including pneumococcal pneumonia, flu and hepatitis B, encouraging people with type 1 or type 2 diabetes to talk with their HCP about these diseases. As part of the collaboration, an educational resource is available on the Association’s Diabetes Forecast website to help guide adults with diabetes to have informed conversations with their health care team: www.DiabetesForecast.org/knowyourrisk. Nearly 30 million people in the United States are living with diabetes, and 90-95 percent have type 2 diabetes. About 1.4 million Americans are diagnosed with diabetes every year. 2,3 Pneumococcus refers to the bacterium that is the most common cause of lung infection known as pneumococcal pneumonia. The bacteria can infect the upper respiratory tract, and can spread to the lungs, blood or brain. Symptoms of pneumococcal pneumonia can include sudden onset of illness characterized by shaking chills, fever, shortness of breath or rapid breathing, chest pain that is worsened by breathing deeply and a productive cough. This survey was conducted online by Harris Poll on behalf of Merck and the ADA from April 12-26, 2016 among 1,003 U.S. adults age 18 and older who have been diagnosed with type 1 or type 2 diabetes; not employed by a federal, state, county, or local government agency/facility; do not personally work/have a household member who works in a competing industry; and are not currently involved in a medical clinical trial. Data were not weighted and are only representative of those who completed the survey. For over a century, Merck has been a global health care leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to health care through far-reaching policies, programs and partnerships. For more information, visit www.merck.com and connect with us on Twitter, Facebook, YouTube and LinkedIn. More than 29 million Americans have diabetes, and every 23 seconds another person is diagnosed with diabetes. The American Diabetes Association (Association) is the global authority on diabetes and since 1940 has been committed to its mission to prevent and cure diabetes and to improve the lives of all people affected by diabetes. To tackle this global public health crisis, the Association drives discovery in research to treat, manage and prevent all types of diabetes, as well as to search for cures; raises voice to the urgency of the diabetes epidemic; and provides support and advocacy for people living with diabetes, those at risk of developing diabetes and the health care professionals who serve them. For more information, please call the American Diabetes Association at 1-800-DIABETESS (1-800-342-2383) or visit diabetes.org. Information from both of these sources is available in English and Spanish. Find us on Facebook (American Diabetes Association), Twitter (@AmDiabetesAssn) and Instagram (@AmDiabetesAssn) Forward-Looking Statement of Merck & Co., Inc., Kenilworth, N.J., USA This news release of Merck & Co., Inc., Kenilworth, N.J., USA (the “company”) includes “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company’s management and are subject to significant risks and uncertainties. There can be no guarantees with respect to pipeline products that the products will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions. The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company’s 2015 Annual Report on Form 10-K and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site (www.sec.gov).

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