Blinov D.S.,Medical Institute Of arev Mordovian State University |
Sernov L.N.,All Russian Research Center for Safety of Biologically Active Compounds |
Balashov V.P.,Medical Institute Of arev Mordovian State University |
Blinova E.V.,Medical Institute Of arev Mordovian State University |
And 6 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2012
Experiments on rats with myocardium infarction showed that intravenous administration of etoxidol in a dose of 14.2 mg/kg restricted the size of necrosis area and reduced the ratio of necrosis/ischemia zones. The test compound reduced the risk of rhythm and conduction disturbances induced by administration of toxic epinephrine doses to the mice, and increased mouse survival. Etoxidol administered intravenously to cats with acute myocardial ischemia reduced epinephrine concentration and intensity of free radical oxidation in zones of myocardial lesions against the background of the increase in norepinephrine concentration and antioxidant activity in the myocardium. By antiischemic and antioxidant activity, etoxidol was superior to its structural analogue mexidol. © 2012 Springer Science+Business Media, Inc.