Chatterjee S.,Medical College and Hospital |
Rudra A.,P.A. College
Anesthesiology Research and Practice | Year: 2011
Postoperative nausea and vomiting (PONV) are still common following surgery. This is not only distressing to the patient, but increases costs. The thorough understanding of the mechanism of nausea and vomiting and a careful assessment of risk factors provide a rationale for appropriate management of PONV. Strategy to reduce baseline risk and the adoption of a multimodal approach will most likely ensure success in the management of PONV. Copyright © 2011 S. Chatterjee et al.
Kuo M.T.,University of Houston |
Fu S.,University of Houston |
Savaraj N.,Veterans Affairs Medical Center |
Chen H.H.W.,Medical College and Hospital |
Chen H.H.W.,National Cheng Kung University
Cancer Research | Year: 2012
The high-affinity copper transporter (Ctr1; SCLC31A1) plays an important role in regulating copper homeostasis because copper is an essential micronutrient and copper deficiency is detrimental to many important cellular functions, but excess copper is toxic. Recent research has revealed that human copper homeostasis is tightly controlled by interregulatory circuitry involving copper, Sp1, and human (hCtr1). This circuitry uses Sp1 transcription factor as a copper sensor in modulating hCtr1 expression, which in turn controls cellular copper and Sp1 levels in a 3-way mutual regulatory loop. Posttranslational regulation of hCtr1 expression by copper stresses has also been described in the literature. Because hCtr1 can also transport platinum drugs, this finding underscores the important role of hCtr1 in platinum-drug sensitivity in cancer chemotherapy. Consistent with this notion is the finding that elevated hCtr1 expression was associated with favorable treatment outcomes in cisplatin-based cancer chemotherapy. Moreover, cultured cell studies showed that elevated hCtr1 expression can be induced by depleting cellular copper levels, resulting in enhanced cisplatin uptake and its cell-killing activity. A phase I clinical trial using a combination of trientine (a copper chelator) and carboplatin has been carried out with encouraging results. This review discusses new insights into the role of hCtr1 in regulating copper homeostasis and explains how modulating cellular copper availability could influence treatment efficacy in platinum-based cancer chemotherapy through hCtr1 regulation. © 2012 AACR.
Baksi D.P.,Medical College and Hospital |
Pal A.K.,Burdwan Medical College |
Baksi D.,P.A. College
International Orthopaedics | Year: 2011
Forty-one patients with an intercondylar fracture of the humerus (21 recent and 20 ununited) were treated by total elbow arthroplasty using Baksi's recent version of the sloppy hinge from January 2003 to April 2009. Twelve were AO classification type C2 and nine were type C3 recent closed fractures of seven days' mean duration according to Muller classification. Patient's mean age was 64 years. There were 20 nonunions (nine untreated nonunions of a mean of 11 months duration and 11 following failed internal fixation of a mean of 14 months duration); mean patient age was 58 years. The follow up period was 12-88 (mean 55.5) months. Mean arc of postoperative elbow flexion was 25-130° obtained in 39 (95.1%) patients. Mean arc of 65° pronation and 60° supination was obtained in 33(80.5%) patients. According to the Mayo elbow performance score, in the fresh-fracture group, excellent results were seen in 19 (90.5%), good in one (4.8%), and failure in one (4.8%), whereas in the nonunion group, excellent results were obtained in 17 (85%), good in two (10%), and failure in one (5%). Failure in the two patients was due to deep infection requiring prosthesis removal. Other complications were transient ulnar neurapraxia in three, disassembly of the prosthesis in one, patchy heterotopic ossification in two and localised radiolucency around the flanges of the humeral stem in one. © Springer-Verlag 2010.
Weng M.-Y.,Medical College and Hospital |
Weng C.-T.,Section of Allergy |
Liu M.-F.,Medical College and Hospital
Clinical Rheumatology | Year: 2010
Mycophenolate mofetil (MMF) has recently been introduced as an immunosuppressive agent for the treatment of glomerulonephritis with systemic lupus erythematosus (SLE) and the data have been encouraging. However, response to MMF treatment appears to differ ethnically. Therefore, we determined efficacy and safety of low-dose MMF for Taiwanese patients with lupus nephritis. We studied 36 lupus nephritis patients who were treated with MMF. The dose started at 0.5 g/day and we collected the data from patients who received up to 1 g/day MMF. Outcome measures were 24 h for proteinuria, serum creatinine, C3/C4 levels, and anti-dsDNA titers collected at the baseline and at 3-month treatment intervals. Daily urinary protein significantly decreased from 6.15 ± 4.28 g to 2.69 ± 2.36 g at the last visit (P < 0.01) in spite of the significant absence of changes in serum creatinine levels. The response rate was 65.7% including five (14.3%) cases of complete remission and 18 (51.4%) cases of partial remission. The concomitant oral prednisolone dose decreased significantly from 20.07 ± 11.78 mg/day to 13.93 ± 6.79 mg/day at 6 months (P < 0.01). The level of C3 increased significantly from 59.46 ± 32.73 to 71.99 ± 25.81 (P < 0.01) and the antidsDNA antibody titer decreased from 161.71 ± 221.42 to 46.57 ± 117.47 (P < 0.01). No severe adverse effects were observed in the study. Low-dose MMF (0.5 to 1 g/day) combined with glucocorticoids appears to be a safe and effective therapy for lupus nephritis in Taiwanese patients. Our results suggest that lupus nephritis in Oriental patients might respond to lower doses of MMF than Caucasians. © Clinical Rheumatology 2010.
Ghosh A.,ESI PGIMSR and ESIC Medical College |
Biswas A.K.,Medical College and Hospital |
Banerjee A.,IPGME and R
Neurology India | Year: 2015
Background: This study was undertaken to find out if metabolic syndrome (MetS) in the elderly was associated with cognitive decline and also if this association was modified by the presence of inflammation. Materials and Methods: 100 patients more than 60 years of age were divided into 2 groups of 50 each and were age and sex matched. Group 1 and 2 had patients with and without MetS, respectively. The individual components of MetS were measured in each patient. Cognitive decline was measured by Modified Mini-Mental Score (3MS) of Teng. Inflammation was measured by high-sensitivity C-reactive protein (hs-CRP). Results: Fasting hyperglycemia was the most common component of MetS (60% of group 1). The mean serum hs-CRP in patients of group 1 was 6.56 ± 9.72 while that in the patients of group 2 was 1.95 ± 1.93. In the group-1, 36% (n = 18) patients were having a decreased 3MS, whereas in group-2, 22% (n = 11) were having a decreased 3MS. MetS was associated with an odd's ratio of 1.99 for developing cognitive decline. 3MS had a negative correlation with hs-CRP values. Regression analysis showed a significant association of hs-CRP and MetS with cognitive decline in the elderly population. Conclusion: Cognitive decline in the elderly is associated with the presence of inflammation and MetS. Hence, early identification of the high-risk groups may offer benefit by disease course modification and better caregiving.
Kaur H.,Medical College and Hospital |
Gupta B.M.,National Institute of Science
Scientometrics | Year: 2010
The study examines India's performance based on its publication output in dental sciences during 1999-2008, based on several parameters, including the country annual average growth rate, global publication share & rank among 25 most productive countries of the world, national publication output and impact in terms of average citations per paper, international collaboration output and share and contribution of major collaborative partners, contribution and impact of select top 25 Indian institutions and select top 15 most productive authors, patterns of communication in national and international journals and characteristics of its 45 high cited papers. The study uses 10 years (1999-2008) publications data in dental sciences of India and other countries drawn from Scopus international multidisciplinary bibliographical database. © 2010 Akadémiai Kiadó, Budapest, Hungary.
Pai M.-C.,Medical College and Hospital |
Pai M.-C.,National University of Tainan |
Yang Y.-C.,National University of Tainan
Current Alzheimer Research | Year: 2013
Background: Many early-stage Alzheimer's disease (AD) patients suffer from spatial navigational impairment even in familiar environments. Growing evidence shows that the retrosplenial cortex (RSC) is more damaged in young-onset AD patients (YOAD, onset age before 65) than in late-onset AD (LOAD) in the early-stage of AD. Impaired translation between egocentric and allocentric representations of the environment, as a cause for spatial navigational impairment, usually occurs in people with lesions in the RSC. Objective: To test translational ability between spatial representations in early-stage YOAD and LOAD patients. Methods Tests deemed sensitive to translation of spatial representations were used to evaluate 29 AD (14 YOAD, 15 LOAD) and 27 cognitively healthy controls (14 younger NC and 13 older NC). Results: Younger NC outperformed YOAD in the tests of translation of spatial representations in spite of their equal basic visuoperceptual abilities and distance estimation. No such difference existed between LOAD and older NC. Conclusion: The translation of egocentric-allocentric representation ability, as a principal function of RSC, does not deteriorate equally in early-stage AD patients of different onset age. That early-stage YOAD show more deviations in translation of their spatial representation ability deserves our attention because it may endanger their daily activities. © 2013 Bentham Science Publishers.
Raut L.,Medical College and Hospital |
Chakrabarti P.,Medical College and Hospital
South Asian Journal of Cancer | Year: 2014
Relapsed-Refractory Diffuse Large B Cell Lymphoma (RR DLBCL), which accounts for approximately one-third of patients with DLBCL, remains a major cause of morbidity and mortality. Managing RR DLBCL continues to be a challenge to the treating hemato-oncologist. Salvage high-dose chemotherapy followed by autologous stem cell transplantation is the standard of care for chemosensitive relapses in DLBCL. Various salvage regimens are available, but the quest for an optimal regimen continues. The addition of rituximab to the salvage regimen has improved the outcome of RR DLBCL. Several pertinent issues regarding the management of RR DLBCL are discussed in this short review. © 2014. The South Asian Journal of Cancer.
Chattopadhyay S.,Medical College and Hospital |
Das A.,Medical College and Hospital |
Pahari S.,Medical College and Hospital
Journal of Pregnancy | Year: 2014
This prospective observational study compared the effects of general and spinal anesthesia in 173 severe preeclamptic women undergoing emergency cesarean section. 146 (84.5%) patients underwent spinal anesthesia (SA) and 27 (15.5%) patients had general anesthesia (GA). Most of the patients were primigravid and nulliparous. Intraoperatively SA group required more intravenous fluid and vasopressor support, while GA group required more preoperative labetalol injection for blood pressure control. Overall 13.3% of patients required critical care, particularly GA group (44.4% versus 7.5%; P < 0.001). Patients receiving GA had a higher mortality (25.9% versus 1.4%; P < 0.001). The length of hospital stay was comparable. Significantly more neonates of patients receiving GA were found to be preterm (77.8% versus 44.5%; P < 0.01) and required advanced resuscitation. GA group also had higher neonatal mortality (29.6% versus 11%; P < 0.05). To conclude, severe preeclamptic mothers receiving general anesthesia and their babies required more critical care support. Maternal as well as neonatal mortality was significantly higher with general anesthesia. © 2014 Suman Chattopadhyay et al.
Bhattacharya K.,Medical College and Hospital
African Journal of Psychiatry (South Africa) | Year: 2015
Schizophrenia is a mental disorder characterized by delusion, hallucination, formal thought disorder, disorganized or catatonic behavior, negative symptoms (e.g. emotional blunting, decreased initiative, impoverished speech etc.) and cognitive dysfunction. Though not described as diagnostic criteria, cognitive dysfunction is the strongest determinant of functional recovery as it has a gradual deteriorating effect on social and occupational functioning. It precedes coincides and outlasts positive symptoms. Among different cognitive abilities it affects attention, memory, processing speed, social cognition and executive function most. Recent studies are showing schizophrenia affects those who have compromised cognitive function or low IQ. Moreover different brain imaging techniques have shown structural and functional abnormality in certain areas. This article has tried to answer few questions like, are cognitive dysfunctions inevitable in schizophrenic patients and if it is then what are the areas what is the nature of affection. It is also important to know how and why they affect the long term outcome of this disorder. © 2015, Bhattacharya.