Medical Clinic II Grosshadern

München, Germany

Medical Clinic II Grosshadern

München, Germany
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Kostev K.,IMS Health | Parhofer K.G.,Medical Clinic II Grosshadern | Dippel F.-W.,Sanofi S.A.
Cardiovascular Endocrinology | Year: 2017

Introduction Hypercholesterolemia is a causal risk factor for cardiovascular diseases, which is recommended to be treated at least in high-risk patients. Yet, currently there is a lack of epidemiological data on the number of high-risk patients in Germany who do not respond adequately to high-dose statin monotherapy or statin therapy in combination with other lipid-lowering agents. Methods Of a total of over 2.6 million patient records from general practitioners in the IMS Disease Analyzer database, all high-risk cardiovascular patients with hypercholesterolemia who did not reach target low-density lipoprotein-cholesterol (LDL-C) levels despite at least 12 months of maximum lipid-lowering therapy and optimal medication supply (medication possession rate≥80%) were selected over a defined period. Results On the basis of the practice data, a total of 602 133 patients with a high cardiovascular risk who were treated with statin monotherapy or statin combination therapy with optimal medication supply (medication possession rate≥80%) for at least 12 months were identified. Of them, 49 406 patients received high-dose statin therapy, and 51 869 patients received statin therapy in any dose in combination with another lipid-lowering agent. A total of 79 848 high-risk patients did not reach the target LDL-C level of 70 mg/dl or less despite consistent lipid-lowering therapy; of them, 12 808 had a documented LDL-C level of at least 130 mg/dl. Conclusion The prevalence of high-risk cardiovascular patients with therapy-resistant hypercholesterolemia is substantial in Germany. © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.

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