Medical and Industrial Research School AMIRS NSTRI

Karaj, Iran

Medical and Industrial Research School AMIRS NSTRI

Karaj, Iran
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Jalilian A.R.,Medical and Industrial Research School AMIRS NSTRI | Emami A.,Islamic Azad University at Tehran | Akhlaghi M.,Medical and Industrial Research School AMIRS NSTRI | Kamali-dehghan M.,Medical and Industrial Research School AMIRS NSTRI | And 2 more authors.
Radiochimica Acta | Year: 2010

61Cu]-9,10-Phenanthrenequinone thiosemicarbazone ( 61Cu-PQTS) a radiolabeled anticancer compound was prepared for malignant tissue imaging studies. Copper-61 was produced via the natZn(p, x)61Cu nuclear reaction in a 30 MeV cyclotron (150 μA irradiation for 76 min, radionuclidic purity > 95%). 61Cu-PQTS was prepared from in-house synthesized PQTS. Quality control was performed using ITLC. The biodistribution of the tracer was compared to the biodistribution of cationic copper-61 in healthy controls. 61Cu-PQTS was then administered to fibrosarcoma-bearing mice for biodistribution and co-incidence imaging studies. 61Cu-PQTS demonstrated significant tumor uptake of 2.1% ID/g and the tumor was clearly visualized in a fibrosarcoma model. © by Oldenbourg Wissenschaftsverlag, München.


Jalilian A.R.,Medical and Industrial Research School AMIRS NSTRI | Jouiaei M.,Golestan University of Medical Sciences | Doroudi A.,Golestan University of Medical Sciences | Garousi J.,Medical and Industrial Research School AMIRS NSTRI | Moradkhani S.,Medical and Industrial Research School AMIRS NSTRI
Journal of Radioanalytical and Nuclear Chemistry | Year: 2010

In this work, recently prepared 67Ga-labeled glucagon ( 67Ga-DTPA-GCG) for imaging studies (radio-chemical purity [<94%; HPLC, S.A. 296-370 GBq/mM) was used in biological studies. The wild-type rat biodistribution results, 2 h post injection, demonstrated high tissue:muscle ratios for target tissues (liver, kidney, heart, spleen, fat intestine stomach and pancreas), 234, 18.45, 7.12, 1.75, 128.7, 4.9, 6.3 and 1.11, respectively. The tracer binding capacity using freshly prepared rat brain homog-enate demonstrated significant specific binding of the tracer to neuronal GCG receptors (67Ga-DTPA-GCG/67Ga:3 and 67Ga-DTPA- GCG/67GaDTPA:2.2 at 90 min). SPECT images also demonstrated target specific binding of the tracer at 4 h. The data suggests the tracer is accumulated in GCGR rich tissues 2-4 h post injection, suggesting potentials of the tracer for future imaging studies in glocagonoma models. © Akadémiai Kiadó, Budapest, Hungary 2010.


Heidarieh M.,Medical and Industrial Research School AMIRS NSTRI | Heidarieh M.,University of Tehran | Afsharnasab M.,Iranian Fisheries Research Organization | Soltani M.,University of Tehran | And 4 more authors.
Journal of Fisheries and Aquatic Science | Year: 2010

During the period of culture, immunostimulants and even vaccines may provide potential methods to protect shrimps from opportunistic and pathogenic agents. This study was designed to show the effects of Ergosan and Vibromax vaccine against WSSV and Vibrio harveyii in juvenile Litopeaneus vannamei and even growth and survival rate in PL stage. Among different treatments in PL stage, Ergosan significantly enhanced the body weight while in group treated with Ergosan and Vibromax the enhancement in survival rate was observed. Survival rate was also assessed by challenging with Vibrio harveyii and WSSV in juvenile stage. All treatments with Ergosan and Vibromax vaccine showed significant enhancement in survival rate compared to the control groups. This study indicates that Ergosan and Vibromax could be used to promote the health status of shrimp during the period of culture. © 2010 Academic Journals Inc.


Heidarieh M.,Medical and Industrial Research School AMIRS NSTRI | Mirvaghefi A.R.,University of Tehran | Akbari M.,University of Tehran | Sheikhzadeh N.,University of Tabriz | And 3 more authors.
Aquaculture Nutrition | Year: 2013

This study examined the effects of Hilyses™, fermented Saccharomyces cerevisiae (S. cerevisiae), on rainbow trout growth performance, haematological parameters, digestive enzyme activities and gastrointestinal structure. Rainbow trout (mean weight 100-110 g) were fed dietary Hilyses™ (5 g kg-1) and control diet without Hilyses™ for 50 days. Results of this study demonstrated that yeast supplementation in treatment group resulted in increased feed intake, followed by improved feed conversion ratio (FCR) and growth performance. Significant increases were also observed in trypsin and amylase activities in juvenile fish fed treatment diet. Light microscopy demonstrated that both groups of fish displayed normal morphology of proximal intestine and pyloric caeca. In yeast-treated group, higher density of the goblet cells per villus in the proximal intestine was shown. No effects on haematological parameters and carcass chemical composition were noted. It is therefore possible to use fermented S. cerevisiae supplementation to significantly improve the gastrointestinal structure and growth performance in rainbow trout. © 2012 Blackwell Publishing Ltd.


The imunnocompetent cell population size including lymphocyte, neutrophil and eosinophil populations, lysozyme activity in plasma and the growth performance were assessed in great sturgeon Huso huso after oral administration of Ergosan at 0.5% of the feed and Vitacel at 1.3% of the feed for 90 days. Sampling was performed on 15 and 90 days during feeding trial. Generally, a significant increase was seen in the lymphocyte count of fish received Ergosan compared to both Vitacel and control groups 90 days post-treatment (P<0.05). Interstingly, at the Neutrophil profile of fish fed Vitacel and Vitacel- Ergosan combination was observed significant increase on 90 days after trial (P<0.05). The number of eosinophils tended to be higher in Vitacel group (P<0.05) on day 90 and was significantly higher (P<0.05) than in Ergosan and control. Also, lysozyme activity in plasma of treatment fish by Ergosan and Vitacel was significantly higher than control group on 15 and 90 days post-treatment (P<0.05). In addition, the weight of fish fed diet containing Ergosan and/or Vitacel had a significant increase compared to control group on days 15 and 90 of trial (P<0.05). © Published by Central Fisheries Research Institute (CFRI) Trabzon.


Sheikhzadeh N.,University of Tabriz | Karimi Pashaki A.,University of Tabriz | Nofouzi K.,University of Tabriz | Heidarieh M.,Medical and Industrial Research School AMIRS NSTRI | Tayefi-Nasrabadi H.,University of Tabriz
Fish and Shellfish Immunology | Year: 2012

The effects of dietary Ergosan on the growth performance and mucosal immunity in rainbow trout skin were investigated. 60 rainbow trout (100-110g) were randomly assigned to 2 groups in triplicates and fed one of the experimental diet formulated with 5gkg-1 Ergosan or control diet for 50 days. Results showed that on the 45th day of feeding trial, Ergosan supplementation significantly enhanced the growth performance compared to control group. Various enzyme activities, namely lysozyme, protease, alkaline phosphatase and esterase in treatment group were also enhanced on the 45th and 50th day. Skin mucus in Ergosan-fed fish showed the agglutination of erythrocytes while in control group, no visible agglutination was shown. In addition, skin mucus in treatment group showed strong antibacterial activity against Yersinia ruckeri. In conclusion, the major immune components of rainbow trout mucus that are involved in the non-specific immunity were enhanced by administration of Ergosan in 5gkg-1. © 2011 Elsevier Ltd.


Sheikhzadeh N.,University of Tabriz | Heidarieh M.,Medical and Industrial Research School AMIRS NSTRI | Karimi Pashaki A.,University of Tabriz | Nofouzi K.,University of Tabriz | And 2 more authors.
Fish and Shellfish Immunology | Year: 2012

Effects of Hilyses ®, fermented Saccharomyces cerevisiae (S. cerevisiae), on growth, body composition and skin mucus immune components in rainbow trout were quantified. Ninety rainbow trout (105 ± 5 g) were randomly assigned to 2 groups in triplicates and fed dietary Hilyses ® (5 g kg -1) or control diet without Hilyses ® for 50 days. Results of this study demonstrated that growth performance increased significantly by the dietary yeast supplement; however body composition was not affected in treatment group. At the 45th and 50th day of feeding trial, results of mucus samples demonstrated that yeast supplementation in treatment group significantly promoted enzyme activities, namely lysozyme, protease, alkaline phosphatase and esterase compared to control group. Significant increases were also observed in hemagglutination and antibacterial activity against Yersinia ruckeri in fish fed treatment diet. The present study suggests that fermented S. cerevisiae may effectively promote the growth performance and skin non-specific immune parameters in rainbow trout. © 2012 Elsevier Ltd.

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