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Pludowski P.,Childrens Memorial Health Institute | Grant W.B.,Nutrition and Health Research Center | Bhattoa H.P.,Debrecen University | Bayer M.,Charles University | And 9 more authors.
International Journal of Endocrinology | Year: 2014

Little published information is available regarding epidemiological data on vitamin D status in the large geographical region of Central Europe (CE). We searched the journal literature with regard to 25(OH)D concentrations among community-dwelling or healthy people living in CE. 25(OH)D concentrations varied by age, season, study sample size, and methodological approach [i.e., 25(OH)D assay used]. Concentrations of 25(OH)D in CE appeared lower than 30 ng/mL, and the magnitude of hypovitaminosis D was similar to that reported in Western Europe. While most of the studies reviewed were cross-sectional studies, a longitudinal study was also included to obtain information on seasonal variability. The longitudinal study reported wintertime 25(OH)D values close to 21-23 ng/mL for all studied age groups, with a significant increase of 25(OH)D in August reaching 42 ng/mL for those aged 0-9 years, but only 21 ng/mL for the elderly aged 80-89 years. The decrease in 25(OH)D with respect to age was attributed to decreased time spent in the sun and decreased vitamin D production efficiency. Based on the literature review on vitamin D status in the CE populations, it can be concluded that 25(OH)vitamin D levels are on average below the 30 ng/mL level. © 2014 Pawel Pludowski et al. Source


Popryadukhin P.V.,RAS Institute of Macromolecular Compounds | Dobrovolskaya I.P.,RAS Institute of Macromolecular Compounds | Yudin V.E.,RAS Institute of Macromolecular Compounds | Ivan'kova E.M.,RAS Institute of Macromolecular Compounds | And 2 more authors.
Cell and Tissue Biology | Year: 2012

This work considers the structural and mechanical properties of composite materials based on chitosan, as well as montmorillonite micro- and nanoparticles and the possibility of using them for cultivation and targeted delivery of mesenchymal stem and regenerative cells. It has been shown that, upon addition of montmorillonite, the biomaterial acquires stability of structural and mechanical properties under conditions of sterilizational treatment and during manipulations in liquid media in the course of cell cultivation. With the aid of in vitro cultivation with the use of dermal fibroblasts and mesenchymal stem cells of adipose tissue, this material was shown to have a complex of properties providing matrix biocompatibility. © 2012 Pleiades Publishing, Ltd. Source


Gal L.N.,Russian Academy of Sciences | Malachova M.Ya.,Medical Academy of Postgraduate Education | Melenevskaya E.Yu.,RAS Institute of Macromolecular Compounds | Podosenova N.G.,Russian Academy of Sciences | Sharonoa L.V.,RAS Ioffe Physical - Technical Institute
Biomeditsinskaya Khimiya | Year: 2011

In this work, the study of properties of silica gel as an adsorbent for plasmasorption has been performed. Investigations have been realized of the effect of silica gel preliminary treatment conditions and a period of plasma with silica gel contact on plasmasorption characteristics of human blood plasma components, such as protein, triglycerides, cholesterol (high-density and low-density one). The results obtained can be used for variation of silica gel adsorption properties, in situ at the adsorbent preparation process. For explanation of the experimental concentration and kinetic (temporal) characteristics of plasmasorption, the model of silica gel grains charging at the hydration was used. Source


Belenky V.V.,State Hospital no. 26 | Golovkin V.I.,Medical Academy of Postgraduate Education | Koroleva E.M.,Center for Biochemical Studies | Verbitskaya E.V.,St. Petersburg State Medical University | And 3 more authors.
Neurochemical Journal | Year: 2010

It is believed that an imbalance of neurotransmitters plays an important role in the pathogenesis of dystonic hyperkinesis. However, the results of different studies on the exchange of catecholamines during dystonia are contradictory. We found a tendency to an increase in the noradrenaline (NA) level and a trend to a decrease in the level of homovanillic acid (HVA) in the blood of patients with dystonia. This finding indicates that the exchange of catecholamines is disturbed during dystonia. However, the changes observed were significant only for some of the statistical methods used; therefore, this problem needs further investigation. © Pleiades Publishing, Ltd., 2010. Source

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