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A method of evaluating gastrointestinal cancer risk. The method comprises generating a set of features comprising a plurality of current blood test results from a blood collected from a target individual, providing at least one classifier generated according to an analysis of a plurality of respective historical blood test results of each of another of a plurality of sampled individuals, and evaluating, using a processor, a gastrointestinal cancer risk of the target individual by classifying the set of features using the at least one classifier.


Mehrpour O.,Birjand University | Mehrpour O.,Medial Research | Karrari P.,Birjand University | Zamani N.,Shahid Beheshti University of Medical Sciences | And 2 more authors.
Toxicology Letters | Year: 2014

Exposure to pesticides affects many body organs including reproductive system. Disorder of the reproductive system leads to infertility and therefore has been in the center of attention within the recent decades. Pesticides are one of the compounds that might reduce the semen quality in the exposed workers according to current knowledge. Although many underlying mechanisms have been proposed, the mechanisms of action are not clarified yet. The object of the present review was to criticize all the results of studies which evaluated the pesticide effects on male reproductive system. Results indicate that semen changes are multifactorial in the workers exposed to pesticides as there are numerous factors affecting sperm quality in occupational exposures. Majority of pesticides including organophosphoruses affect the male reproductive system by mechanisms such as reduction of sperm density and motility, inhibition of spermatogenesis, reduction of testis weights, reduction of sperm counts, motility, viability and density, and inducing sperm DNA damage, and increasing abnormal sperm morphology. Reduced weight of testes, epididymis, seminal vesicle, and ventral prostate, seminiferous tubule degeneration, change in plasma levels of testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH), decreased level and activity of the antioxidant enzymes in testes, and inhibited testicular steroidogenesis are other possible mechanisms. Moreover, DDT and its metabolites have estrogenic effects on males. Although effect of pesticides on sperm quality is undeniable, well-designed long-term studies are needed to elucidate all the possible affecting variables such as socioeconomic, cultural, nutritional, occupational, physical, and clinical characteristics alongside pesticides. © 2014 Elsevier Ireland Ltd.


Pikov V.,Medial Research | Arakaki X.,Medial Research | Harrington M.,Medial Research | Fraser S.E.,California Institute of Technology | Siegel P.H.,California Institute of Technology
Journal of Neural Engineering | Year: 2010

As millimeter waves (MMWs) are being increasingly used in communications and military applications, their potential effects on biological tissue has become an important issue for scientific inquiry. Specifically, several MMW effects on the whole-nerve activity were reported, but the underlying neuronal changes remain unexplored. This study used slices of cortical tissue to evaluate the MMW effects on individual pyramidal neurons under conditions mimicking their in vivo environment. The applied levels of MMW power are three orders of magnitude below the existing safe limit for human exposure of 1 mW cm -2. Surprisingly, even at these low power levels, MMWs were able to produce considerable changes in neuronal firing rate and plasma membrane properties. At the power density approaching 1 μW cm -2, 1 min of MMW exposure reduced the firing rate to one third of the pre-exposure level in four out of eight examined neurons. The width of the action potentials was narrowed by MMW exposure to 17% of the baseline value and the membrane input resistance decreased to 54% of the baseline value across all neurons. These effects were short lasting (2 min or less) and were accompanied by MMW-induced heating of the bath solution at 3°C. Comparison of these results with previously published data on the effects of general bath heating of 10°C indicated that MMW-induced effects cannot be fully attributed to heating and may involve specific MMW absorption by the tissue. Blocking of the intracellular Ca 2+-mediated signaling did not significantly alter the MMW-induced neuronal responses suggesting that MMWs interacted directly with the neuronal plasma membrane. The presented results constitute the first demonstration of direct real-time monitoring of the impact of MMWs on nervous tissue at a microscopic scale. Implication of these findings for the therapeutic modulation of neuronal excitability is discussed. © 2010 IOP Publishing Ltd.


News Article | November 14, 2016
Site: www.prweb.com

Today, Medical Research Alliance (MRA) has chosen StudyKIK, a clinical trial patient recruitment company that specializes in connecting quality patient groups through social media communities to clinical research sites, as their preferred recruitment provider. This selection has taken into effect due to the increase in clinical trials across the MRA site network. “StudyKIK is able to consistently provide high volumes of quality patients, and has proven to be much more effective than traditional advertising mediums. We have selected StudyKIK as our Preferred Recruitment Provider because they have played a large part in MRA developing a reputation of a network of high enrolling sites,” said MRA Director of Business Development, Drew Moffat. With more than 650 years of combined research experience, Medical Research Alliance helps Sponsors and CROs streamline the site selection process across a wide variety of therapeutic areas. As preferred recruitment provider, StudyKIK will now gain access to more than 800 clinical trials per year run by MRA. Under this new partnership, StudyKIK will use their resources to help bring patients to Medial Research Alliance’s 250 investigators and 30 independently owned research sites. “We look forward to extending our long relationship with MRA and their high performing sites. Their sites and key leadership, especially Doug Surowitz and Drew Moffat, are pioneers in this industry and have been an asset to helping StudyKIK develop as the fastest growing patient recruitment platform, “ stated Jerome Chiaro, Vice President of Clinical Site Operations at StudyKIK. StudyKIK continues to focus on expanding the awareness of clinical trials globally while providing research sites with as many tools as possible to enroll clinical trial volunteers. To learn more about StudyKIK, visit StudyKIK.com. To learn more about Medical Research Alliance, visit http://medicalresearchalliance.com/


Gill A.J.,Royal North Shore Hospital | Gill A.J.,Medial Research | Gill A.J.,University of Sydney
Endocrine Pathology | Year: 2014

Parathyroid carcinoma has always been difficult to diagnose pathologically. In fact, most parathyroid tumors which are classified as carcinoma do not recur after excision, and most parathyroid tumors which actually metastasize or recur repeatedly in the neck are not recognized as malignant at first presentation. In 2002, germline HRPT2 (also known as CDC73) mutation was reported as the cause of hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant hereditary tumor syndrome associated with a lifetime risk of parathyroid carcinoma approaching 15 %. Subsequently, bi-allelic inactivation or mutation of HRPT2 has been reported in the majority of parathyroid carcinomas that actually behave in a malignant manner but very rarely in sporadic benign parathyroid disease. Furthermore, germline testing for HRPT2 mutation in patients presenting with parathyroid carcinoma often identifies occult HPT-JT syndrome even in the absence of a family history or other syndromic manifestations. HRPT2 mutation testing is not readily available, and loss of expression of parafibromin (the protein encoded by HRPT2) as determined by immunohistochemistry has been used as a surrogate marker of HRPT2 mutation. Immunohistochemistry for parafibromin can be technically difficult and has been deployed by different investigators with variable enthusiasm and success. However, proponents have found immunohistochemistry for parafibromin useful to definitively confirm a pathological diagnosis of parathyroid carcinoma, predict a worse outcome in definite parathyroid carcinomas, triage formal genetic testing for HPT-JT syndrome, and predict the outcome of histologically atypical parathyroid adenomas. © 2014 Springer Science+Business Media.


Jin Y.-R.,Medial Research | Yoon J.K.,Medial Research
International Journal of Biochemistry and Cell Biology | Year: 2012

Recently, the R-spondin (RSPO) family of proteins has emerged as important regulators of WNT signaling. Considering the wide spectrum of WNT signaling functions in normal biological processes and disease conditions, there has been a significantly growing interest in understanding the functional roles of RSPOs in multiple biological processes and determining the molecular mechanisms by which RSPOs regulate the WNT signaling pathway. Recent advances in the RSPO research field revealed some of the in vivo functions of RSPOs and provided new information regarding the mechanistic roles of RSPO activity in regulation of WNT signaling. Herein, we review recent progress in RSPO research with an emphasis on signaling mechanisms and biological functions. © 2012 Elsevier Ltd. All rights reserved.


Satyanarayana K.,Medial Research
Indian Journal of Physiology and Pharmacology | Year: 2010

This paper traces the evolution of measures and parameters for the evaluation of science and scientific journals from the first attempts during the early part of the last century to the development of the most popular, current and widely used metrics viz., citations, impact factor (IF) etc. The identification of measures of evaluation in science and scientific reporting paralled the post-war increase in funding in the United States of America. Biomedical and medical sciences continue to garner a major share, estimated to be almost two-thirds of total research and development funding of over US$ 350 billion. There has been a concomitant growth in the publications in learned journals. About 1.4 million papers are published every year in an estimated 20,000 journals. In India there are an estimated 100 journals in medical sciences. With a steady increase of about 10% every year, the competition for grants, awards, rewards etc., is fierce. This unrelenting increase in number of scientists and the resultant competition, the limitation of peer review was felt. A search was on for new quantifiable measures for informed decision making for funding, awards, rewards, etc. Now virtually all major decisions all over the world are based on some data linked to publications and/or citations. The concept of citations as tool for 'evaluating' science was first proposed by Eugene Garfield in 1955. The availability of Science Citation Index (SCI), Journal Citation Reports (JCR), Web of Science etc. and the relative ease with which they could be used (and abused) has spawned an entirely new area bibliometrics/scientometrics. As only a limited number of journals could be included in the Thomson Reuters (TR) databases (currently numbering about 10500), analyses based on such a limited dataset (also selected in a non-transparent way by the TR) has been widely and severely criticized by both the developed and developing countries. Yet, studies have shown that citation-based data and indicators (warts and all) could still be put to productive use for purposes of evaluation (as scientists just love numbers). There were simultaneous efforts to find alternative indicators using the TR databases, and through other innovative methods. Some of these include Google Scholar, PageRank, H-index, Y-factor, Faculty of 1000, Eigen Factor etc. The advantages and limitations of these indices are discussed. There is a need for a more critical look at these parameters from the Indian perspective to compute/ device/adapt these measures to suit our needs. There are 205 journals under the category Physiology and 201 in the Pharmacology category listed in the JCR. There are four major Indian journals under the category of Physiology and Pharmacology and none of them are listed in the TR databases reflecting the limitation of these databases. Eventually, and in the long run, the quality of our journals needs to be improved as the current era of globalization and web-access provides both a challenge and an opportunity for the science and scientific journals published from India to get increased global visibility.


Patent
Medial Research | Date: 2014-11-05

A method of evaluating lung cancer risk by generating a set of features comprising a plurality of current blood test results from a blood collected from a target individual, providing at least one classifier generated according to an analysis of a plurality of respective historical blood test results of each of another of a plurality of sampled individuals, and evaluating, using a processor, a lung cancer risk of said target individual by classifying said set of features using said at least one classifier. Each of said plurality of historical and current blood test results comprises results of one or more selected blood tests such as white blood cells blood test results, biochemistry test results, platelets blood test results including at least one of platelets count and mean platelet volume (MPV) and/or a combination of smoking history and red cell test results.


A method of evaluating gastrointestinal cancer risk. The method comprises generating a set of features comprising a plurality of current blood test results from a blood collected from a target individual, providing at least one classifier generated according to an analysis of a plurality of respective historical blood test results of each of another of a plurality of sampled individuals, and evaluating, using a processor, a gastrointestinal cancer risk of the target individual by classifying the set of features using the at least one classifier.


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