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Lynnwood, WA, United States

Sun X.,Medetech Development Corp. | Cao Z.,Medetech Development Corp. | Yeh C.-K.,University of Texas Health Science Center at San Antonio | Sun Y.,University of Massachusetts Lowell
Colloids and Surfaces B: Biointerfaces | Year: 2013

Colonization and biofilm-formation of Candida species on denture surfaces cause Candida-associated denture stomatitis (CADS), a common, recurring disease affecting up to 67% of denture wearers. We developed poly(. N-vinyl-2-pyrrolidinone)-grafted denture materials that can be repeatedly recharged with various antifungal drugs to achieve long-term antifungal and biofilm-controlling effects. The monomer, N-vinyl-2-pyrrolidinone (NVP), was grafted onto poly(methyl methacrylate) denture resins through plasma-initiated grafting polymerization. The physical properties and biocompatibility of the resulting resins were not negatively affected by the presence of up to 7.92% of grafted poly (. N-vinyl-2-pyrrolidinone) (PNVP). Miconazole and chlorhexidine digluconate (CD) were used as model antifungal drugs. PNVP grafting significantly increased the drug absorption capability of the resulting denture materials. Further, the new materials showed sustained drug release and provided antifungal effects for weeks (in the case of CD) to months (in the case of miconazole). The drug-depleted resins could be recharged with the same or a different class of antifungal drug to further extend antifungal duration. If needed, drugs on the PNVP-grafted denture materials could be "washed out" (quenched) by treating with PNVP aqueous solutions to stop drug release. These results point to great potentials of the new materials in controlling biofilm-formation in a wide range of device-related applications. © 2013 Elsevier B.V.

Cao Z.,Medetech Development Corp. | Sun X.,Medetech Development Corp. | Yao J.,Fudan University | Sun Y.,Fudan University | Sun Y.,University of Massachusetts Lowell
Journal of Bioactive and Compatible Polymers | Year: 2013

Sulfadiazine was immobilized onto cotton cellulose using ethylene glycol diglycidyl ether as a binder. Upon treatment with diluted silver nitrate aqueous solution, the sulfadiazine moieties in the immobilized celluloses were transformed into silver-sulfadiazine coordination complexes. The resulting silver sulfadiazine-immobilized celluloses provided a 6-log reduction of 108 CFU mL-1 of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), methicillin-resistant Staphylococcus aureus (drug-resistant bacteria), vancomycin-resistant Enterococcus faecium (drug-resistant bacteria), and Candida albicans (fungi) in 30-60 minutes, and a 5-log reduction of 107 PFU mL-1 of MS2 virus in 120 minutes. The antibacterial, antifungal, and antiviral activities were both durable and rechargeable. Additionally, trypan blue assay suggested that the new silver sulfadiazine-immobilized celluloses sustained excellent mammal cell viability, pointing to great potentials of the new materials for a broad range of health care-related applications. © The Author(s) 2013.

Medetech Development Corp. | Date: 2013-07-24

Deodorizing products, namely, all purpose deodorizer preparations for household, commercial and industrial use.

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