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News Article | May 12, 2017
Site: cen.acs.org

The American Chemical Society has announced the slate of candidates for this fall’s election. The winners will serve on the ACS Board of Directors from 2018 through 2020. The two candidates for 2018 president-elect are Bonnie A. Charpentier, senior vice president, Cytokinetics, South San Francisco; and Willie E. May, director of research and special initiatives at the University of Maryland, College Park. The winner will serve a three-year term on the board as a member of the presidential succession. The candidates for director of District III are Alan B. Cooper, president of Cooper MedChem Consulting, in West Caldwell, N.J.; and Teri Quinn Gray, regional technology manager for DuPont Performance Materials, in Wilmington, Del. The candidates for director of District VI are Rita R. Boggs, CEO, American Research & Testing, in Gardena, Calif.; and Paul W. Jagodzinski, professor and dean, Northern Arizona University, in Flagstaff. Four candidates are vying for two director-at-large openings: Kenneth P. Fivizzani, who is retired from Nalco, in Naperville, Ill.; Wayne E. Jones Jr., professor and chair of chemistry at the State University of New York, Binghamton; Bonnie A. Lawlor, who is retired from the National Federation of Abstracting & Information Services, Philadelphia; and Barbara A. Sawrey, associate vice chancellor for academic affairs and dean of undergraduate education at the University of California, San Diego. Candidate statements will run in the Sept. 11 issue of C&EN. ACS members will have the option of voting for president-elect and other members of the board of directors via the Internet, or they can opt-in to receive a paper ballot, which will be mailed at the end of September. Results will be announced in early November.


Pelcman B.,Uppsala University | Sanin A.,Biolipox AB | Nilsson P.,Uppsala University | Nilsson P.,Biolipox AB | And 14 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors. © 2015 Elsevier Ltd. All rights reserved.


Pelcman B.,Uppsala University | Sanin A.,Biolipox AB | Nilsson P.,Uppsala University | Nilsson P.,Biolipox AB | And 11 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

High-throughput screening was used to find selective inhibitors of human 15-lipoxygenase-1 (15-LOX-1). One hit, a 1-benzoyl substituted pyrazole-3-carboxanilide (1a), was used as a starting point in a program to develop potent and selective 15-LOX-1 inhibitors. © 2015 Elsevier Ltd. All rights reserved.


PubMed | Uppsala University, MedChem ApS, Biolipox AB and Karolinska University Hospital
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2015

High-throughput screening was used to find selective inhibitors of human 15-lipoxygenase-1 (15-LOX-1). One hit, a 1-benzoyl substituted pyrazole-3-carboxanilide (1a), was used as a starting point in a program to develop potent and selective 15-LOX-1 inhibitors.


PubMed | Uppsala University, MedChem ApS, Biolipox AB and Karolinska University Hospital
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2015

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

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