Entity

Time filter

Source Type

Kawasaki, Japan

Ihara H.,Toho University | Watanabe T.,University of Hyogo | Hashizume N.,Wayo Womens University | Totani M.,Showa Womens University | And 17 more authors.
Annals of Clinical Biochemistry | Year: 2010

Background: The aim of the present study was to evaluate standard reference material (SRM) 1955 commutability as a reference material for serum folate using automated methods. We also designed so as to reduce the intermethod variability present in different automated methods. Methods: Using a microbiological assay related to the 'information value' of SRM 1955 as a comparison method, we investigated the possibility of standardization for the assay values of serum folate as measured by the automated methods (Access, Centaur and Elecsys). In the assay of 50 patient sera by these automated methods, we corrected observed values by the SRM 1955 and compared with comparison values. Results: The observed values of SRM 1955 Levels I, II and III were within or outside (but near) a 95% prediction interval obtained from patient sera by the automated methods. The normalized residuals obtained from SRM 1955 were within ± 3.0 (in SD units), which enabled us to conclude that the SRM 1955 had a physicochemical characterization similar to native serum. Twelve patients were assessed as hypofolataemia (<6.0 ng/mL) and 38 patients as normal (≥6.0 ng/mL). Before correction, folate levels in six of 12 patients were lower than 6.0 ng/mL, and those in seven of 38 patients were higher than 6.0 ng/mL with the automated methods. After correction, low levels were found in four of 12 patients, and normal levels were found in 33 of 38 patients. Conclusions: The use of SRM 1955 would help to reduce the intermethod variability present in different automated methods for serum folate measurement. Source


Ishii N.,Kitasato University | Carmines P.K.,University of Nebraska at Omaha | Yokoba M.,Kitasato University | Imaizumi H.,Kitasato University | And 8 more authors.
Clinical Science | Year: 2013

Experiments were performed to evaluate the hypothesis that ACE (angiotensin-converting enzyme) inhibition (enalapril) suppresses 3-NT (3-nitrotyrosine) production in the renal cortex during the early stage of Type 1 DM (diabetes mellitus) in the rat. Enalapril was administered chronically for 2 weeks to subsets of STZ (streptozotocin)-induced DM and vehicle-treated sham rats. O2 - (superoxide anion) and NOx (nitrate+nitrite) levels were measured in the media bathing renal cortical slices after 90 min incubation in vitro. SOD (superoxide dismutase) activity and 3-NT content were measured in the renal cortex homogenate. Renal cortical nitrated protein was identified by proteomic analysis. Renal cortical production of O2 - and 3-NT was increased in DM rats; however, enalapril suppressed these changes. DM rats also exhibited elevated renal cortical NOx production and SOD activity, and these changes were magnified by enalapril treatment. 2-DE (two-dimensional gel electrophoresis)-based Western blotting revealed more than 20 spots with positive 3-NT immunoreactivity in the renal cortex of DM rats. Enalapril treatment blunted the DM-induced increase in tyrosine nitration of three proteins ACO2, GDH1 and MMSDH (aconitase 2, glutamate dehydrogenase 1 and methylmalonate-semialdehyde dehydrogenase), each of which resides in mitochondria. These data are consistent with enalapril preventing DM-induced tyrosine nitration of mitochondrial proteins by a mechanism involving suppression of oxidant production and enhancement of antioxidant capacity, including SOD activation. © 2013 The Author(s). Source


Aoki Y.,Mecom Co.
Rinsho byori. The Japanese journal of clinical pathology | Year: 2013

The Committee on the Standardization of Diabetes Mellitus-Related Laboratory Testing of the Japan Diabetes Society (JSD) released "International clinical harmonization of hemoglobin A1c in Japan: From JDS to NGSP values". In the document, the Japanese Ministry of Health, Labor, and Welfare, related academic societies, manufacturers and others, and the council meeting of JDS finally decided to use NGSP values in clinical practice from April 1, 2012. They also decided to use the JDS value as usual at specific health checkups and in specific health guidance for one year since the conversion of a great number of digital data needs a lot of time and is costly, and the conversion influences assessment systems markedly. As soon as the document was released, our laboratory (commercial laboratory) noticed that clients at clinics, hospitals and health checkup institutions were aware of the change (or no change) of the HbA1c notation. Subsequently, we set up analysis equipment to output the NGSP value and altered the settings of the laboratory information system to convert the JDS value from the NGSP value. In fact, the health checkup institutions took only the JDS value and the clinics and hospitals took the NGSP and JDS values together. In October 2012, JDS decided that only the NGSP value should be used at specific health checkups and in specific health guidance from April 1, 2013. In conclusion, the performance of international harmonization of HbA1c in Japan was considered to be of great significance. Source


Trademark
Lasalle Business Credit Llc, Finanz St. Honore and Mem Company | Date: 1998-01-13

shaving apparatus, namely, razor handles, razor blades, multi-blade cartridges, stands or holders for some or all of these items, and gift sets combining some or all of these items. shaving brushes, stands for shaving brushes, and gift sets including shaving brushes.


Trademark
Mem Company and Dana Perfumes Corporation | Date: 1998-05-15

SUNGLASSES. STATIONERY, PENS, NOTE CARDS, PENCILS, ERASERS, NOTEBOOKS AND DECALS. BACKPACKS, TOTES, PURSES AND WALLETS. LUNCH BOXES. BEACH TOWELS. TEE SHIRTS, SWEATSHIRTS, SHORTS, UNDERWEAR, TUBE TOPS, FLIP FLOPS, AND SANDALS. BARRETTES. WATER GUNS; WATER TOYS, NAMELY, TOY RINGS IN THE NATURE OF PLASTIC RINGS, BLOW-UP BEACH BALLS.

Discover hidden collaborations