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Kawasaki, Japan

Trademark
Mebiol Inc. | Date: 2011-02-08

Water absorbing polyacrylate resin, artificial plant-cultivating soil containing water absorbing polyacrylate resin, culture growing media for cells or tissues except for medical use, chemicals, namely, industrial chemicals, chemicals for treating hazardous waste, plant growth regulation preparations, adhesives except for office or home use, higher fatty acids for agricultural or industrial purposes, non-metallic minerals, namely, sulphur, huntite, plastic materials, namely, unprocessed plastic materials in powder, liquid or paste form, thermosetting plastic refractory materials, paper and sulphite pulp, flour and starch for industrial purposes, fertilizers, photographic supplies, namely, photographic chemicals, emulsions, chemical test papers, artificial sweeteners, ceramic glazings.


Trademark
Mebiol Inc. | Date: 2010-11-23

[ Chemical fertilizers, natural fertilizers, complexe fertilizers, artificial soil for plant cultivation, plant growth regulating preparations, polymerization plastics; chemicals for use in agriculture, except fungicides, herbicides, insecticides and parasiticides ]. Agricultural implements or machines, namely, seeders, hay balers, cultivators, harvesters, tractor-towed plows and reapers. Plastic films, tubes, or sheeting for agricultural purposes [; semi-worked plastic in the form of pellets, rods, foils, foams, fibers, films and sheets, for use as materials ]. Flower pots; hydroponic apparatus for domestic horticultural purposes, namely, hydroponic garden kit for home use comprising growing containers and also including hydroponic fertilizers, seeds, substrate, and drain components. Frozen vegetables, frozen fruits, processed vegetables * not including vegetable juices for cooking, * processed fruits. Unprocessed edible seaweed, fresh vegetables, fresh fruits, live trees, live grasses, turf, seedlings, live young plants, flowers, potted dwarfed trees in the nature of bonsai.


Sugama K.,Waseda University | Sugama K.,Nihon University | Suzuki K.,Waseda University | Suzuki K.,Tokyo University of Agriculture and Technology | And 6 more authors.
Exercise Immunology Review | Year: 2015

Thioredoxin (TRX) is a 12 kDa protein that is induced by oxidative stress, scavenges reactive oxygen species (ROS) and modulates chemotaxis. Furthermore it is thought to play a protective role in renal ischemia/reperfusion injury. Complement 5a (C5a) is a chemotactic factor of neutrophils and is produced after ischemia/reperfusion injury in the kidney. Both TRX and C5a increase after endurance exercise. Therefore, it may be possible that TRX has an association with C5a in renal disorders and/or renal protection caused by endurance exercise. Accordingly, the aim of this study was to investigate relationships among the changes of urine levels of TRX, C5a and acute kidney injury (AKI) caused by ischemia/reperfusion, inflammatory responses, and oxidative stress following intensive endurance exercise. Also, we applied a newly-developed measurement system of neutrophil migratory activity and ROS-production by use of ex vivo hydrogel methodology with an extracellular matrix to investigate the mechanisms of muscle damage. Fourteen male triathletes participated in a duathlon race consisting of 5 km of running, 40 km of cycling and 5 km of running were recruited to the study. Venous blood and urine samples were collected before, immediately following, 1.5 h and 3 h after the race. Plasma, serum and urine were analyzed using enzyme-linked immunosorbent assays, a free radical analytical system, and the ex vivo neutrophil functional measurement system. These data were analyzed by assigning participants to damaged and minor-damage groups by the presence and absence of renal tubular epithelial cells in the urinary sediments. We found strong associations among urinary TRX, C5a, interleukin (IL)-2, IL-4, IL-8, IL-10, interferon (IFN)-γ and monocyte chemotactic protein (MCP)-1. From the data it might be inferred that urinary TRX, MCP-1 and β-N-acetyl-D-glucosaminidase (NAG) were associated with renal tubular injury. Furthermore, TRX may be influenced by levels of IL-10, regulate chemotactic activity of C5a and IL-8, and control inflammatory progress by C5a and IL-8. In the longer duration group (minor-damage group), circulating neutrophil count, plasma concentration of myeloperoxidase (MPO) and serum concentration of myoglobin were markedly increased. In the higher intensity group (damaged group), neutrophil activation and degranulation of MPO might be inhibited, because not only was ROS production observed to be higher, but also antioxidant capacity and antiinflammatory cytokines were increased. Critically, the newlydeveloped ex vivo methodology corroborated the neutrophil activation levels in the two groups of participants. © 2002 by Hinnak Northoff.


Trademark
Mebiol Inc. | Date: 2010-11-23

Polymer water absorbent for use in soil for plant cultivation, artificial soil containing water absorbent for plant cultivation, culture media for cells or tissues for scientific and research use, chemicals for use in industry and science, plant growth regulating preparations, adhesives not for household or stationary use, higher fatty acids for the manufacture of soap and laundry detergent; non-metallic minerals, namely, sulphur, huntite, diatomite, dolomite, niter, or bentonite; plastic materials, namely, unprocessed plastic materials in powder, liquid, or paste form; paper pulp; flour and starch for industrial purposes, namely, for use in manufacturing paper and textiles; photographic supplies, namely, photographic chemicals and emulsions; chemical test papers, artificial sweeteners, ceramic glazings. Agricultural implements and machines, namely, seeders, hay balers, cultivators, harvesters, tractor-towed plows and reapers. Plastic films, tubes, or sheeting for agricultural purposes; semi-worked plastic in the form of pellets, rods, foils, foams, fibers, films and sheets, for use as materials. Flower pots; hydroponic apparatus for domestic horticultural purposes, namely, hydroponic garden kit for home use comprising growing containers and also including hydroponic fertilizers, seeds, substrate, and drain components. Frozen vegetables, frozen fruits, processed vegetables, processed fruits. Unprocessed edible seaweed, fresh vegetables, fresh fruits, live trees, live grasses, turf, seedlings, live young plants, flowers, potted dwarfed trees in the nature of bonsai.


Suzuki K.,Waseda University | Suzuki K.,Tokyo University of Agriculture and Technology | Ohno S.,Waseda University | Ohno S.,Tokyo Womens Medical University | And 11 more authors.
Anticancer Research | Year: 2012

Background/Aim: Oxidative stress in cancer patients has been demonstrated to be partly mediated by neutrophils. Although it is reported that natural antioxidants, such as green tea extract, reduce oxidative stress, there is limited evidence of their effects in cancer patients. This study aimed to determine the effect of green tea extract on reactive oxygen species produced by neutrophils from cancer patients. Materials and Methods: Peripheral blood samples were obtained from eighteen patients with advanced cancer. Green tea extract was added to the blood samples with luminol on Mebiol gel, and luminol-dependent chemiluminescence was measured to monitor the production of reactive oxygen species from migrated neutrophils into the gel, at 37°C. Results: Luminol-dependent chemiluminescence was significantly down-regulated in the presence of green tea extract in a concentration-dependent manner. Conclusion: These results indicate the antioxidant effect of green tea extract on reactive oxygen species produced by neutrophils, which may be effective in reducing oxidative stress in cancer patients.

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