Md University Rohtak

Rohtak, India

Md University Rohtak

Rohtak, India
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Kumar M.,Babasaheb Bhimrao Ambedkar University | Bauddh K.,Central University of Jharkhand | Sainger M.,Md University Rohtak | Sainger P.A.,Md University | Singh R.P.,Babasaheb Bhimrao Ambedkar University
Agroecology and Sustainable Food Systems | Year: 2015

Inorganic fertilizers release numerous hazardous gases into the atmosphere by volatilization as well as release ionic radicles into surface runoff and ground water by leaching. There is need to develop some sound alternatives to enhance crop productivity without harming the environment. This study was conducted to evaluate the effects of ecofriendly organic matrix-entrapped biofertilizers (OMEB) (Azotobacter chroococcum+Bacillus subtilis) on Basmati rice (Oryza sativa L cv. Basmati). The entrapped biofertilizers significantly increased plant growth, that is, fresh and dry weights, root length, root, leaf and tiller numbers, soluble protein, organic nitrogen, and free ammonium in leaves over free biofertilizers. The crop productivity, that is, grain and straw yield, and quality of grains in terms of grain protein, percentage of moisture, grain starch, wet gluten in grains, as well as NPK in grains and straw were also enhanced by OMEB. We concluded that the efficacy of free biofertilizers can be enhanced by entrapping them in appropriate carriers and providing protection to the biofertilizer microbes. It appears that organic matrix entrapped biofertilizers can be developed as effective organic alternative to conventional chemical fertilizers for rice cultivation in semiarid subtropical agroecosystem. Copyright © Taylor & Francis Group, LLC.


Kaushik C.P.,Guru Jambheshwar University of Science and Technology | Sharma N.,Bhagwan Mahavir Institute of Engineering and Technology | Kumar S.,Md University Rohtak | Kaushik A.,Guru Jambheshwar University of Science and Technology
Bulletin of Environmental Contamination and Toxicology | Year: 2012

Blood samples were collected during August 1992 and August 2002 from various hospitals of Haryana state and analyzed for the presence of HCH and DDT residues and the change in concentration of pesticide residues was calculated in terms of % reduction. The study revealed that the mean residue levels of total HCH in human blood samples have declined by 87.6 % while those of total DDT have decreased by 98.9 % during a gap of 10 years. The obtained results reveal that during 1992 p,p′-DDT was the major component with the mean value of 6.125 mg/L followed by p,p′-DDE, γ-HCH, α-HCH and β-HCH while in 2002, β-HCH and p,p′-DDE were comparable with mean value of 0.053 and 0.052 mg/L, respectively followed by p,p′-DDT, α-HCH and p,p′-DDD. © Springer Science+Business Media, LLC 2012.


Panghal M.,Md University Rohtak | Arya V.,Md University Rohtak | Yadav S.,Md University Rohtak | Kumar S.,Md University Rohtak | Yadav J.P.,Md University Rohtak
Journal of Ethnobiology and Ethnomedicine | Year: 2010

Background: Plants have traditionally been used as a source of medicine in India by indigenous people of different ethnic groups inhabiting various terrains for the control of various ailments afflicting human and their domestic animals. The indigenous community of snake charmers belongs to the 'Nath' community in India have played important role of healers in treating snake bite victims. Snake charmers also sell herbal remedies for common ailments. In the present paper an attempt has been made to document on ethno botanical survey and traditional medicines used by snake charmers of village Khetawas located in district Jhajjar of Haryana, India as the little work has been made in the past to document the knowledge from this community.Methods: Ethno botanical data and traditional uses of plants information was obtained by semi structured oral interviews from experienced rural folk, traditional herbal medicine practitioners of the 'Nath' community. A total of 42 selected inhabitants were interviewed, 41 were male and only one woman. The age of the healers was between 25 years and 75 years. The plant specimens were identified according to different references concerning the medicinal plants of Haryana and adjoining areas and further confirmation from Forest Research Institute, Dehradun.Results: The present study revealed that the people of the snake charmer community used 57 medicinal plants species that belonged to 51 genera and 35 families for the treatment of various diseases. The study has brought to light that the main diseases treated by this community was snakebite in which 19 different types of medicinal plants belongs to 13 families were used. Significantly higher number of medicinal plants was claimed by men as compared to women. The highest numbers of medicinal plants for traditional uses utilized by this community were belonging to family Fabaceae.Conclusion: This community carries a vast knowledge of medicinal plants but as snake charming is banned in India as part of efforts to protect India's steadily depleting wildlife, this knowledge is also rapidly disappearing in this community. Such type of ethno botanical studies will help in systematic documentation of ethno botanical knowledge and availing to the scientific world plant therapies used as antivenin by the Saperas community. © 2010 Panghal et al; licensee BioMed Central Ltd.


Kaur H.,Md University Rohtak | Yadav S.,Md University Rohtak | Narasimhan B.,Md University Rohtak
Central Nervous System Agents in Medicinal Chemistry | Year: 2015

In last decade, the development of new drugs and drug products for central nervous system (CNS) has remained limited due to incomplete elucidation of pathophysiology of many CNS disorders, complexity of the diseases and the lack of technologies for delivery through the blood-brain barrier (BBB). In this article we will summarize the development of diazenyl derivatives of many biologically active moieties like benzodiazepine, formazan, indole, pyrimidine, thiazole, sulfonamide etc. as diagnostic and therapeutic agents for CNS. The potential of already existing azo compounds as potent CNS agents have also been discussed. This overview will provide the researchers an opportunity for further development of new diazenyl derivatives in CNS area. © 2015 Central Nervous System Agents in Medicinal Chemistry All Right reserved.


Hussain S.,Md University Rohtak | Kaushik D.,Md University Rohtak
Journal of Saudi Chemical Society | Year: 2015

Several-1-carbothioamide-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 2a-d, 1-(pyridine-4-ylcarbonyl)-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 3a-d, 1-(5-chloro-6-fluoro-1,3-benzothiazole-2-yl)thiocarbamoyl-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 4a-d and 1-[(1,2,4-triazole-4-yl) carbothioamide]-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 5a-d were synthesized. The structures of the newly synthesized compounds were supported by IR, 1H NMR and mass spectral data. These compounds were investigated for their, anti-inflammatory, analgesic, ulcerogenic, lipid peroxidation, antibacterial and antifungal activities. Some of the synthesized compounds showed potent anti-inflammatory activity along with minimal ulcerogenic effect and lipid peroxidation, compared to ibuprofen and flurbiprofen. Some of the tested compounds also showed moderate antimicrobial activity against tested bacterial and fungal strains. © 2012.


PubMed | Md University Rohtak
Type: Journal Article | Journal: Anti-cancer agents in medicinal chemistry | Year: 2016

In the past years, many diazenyl compounds (i.e diazenecarboxamides, diazeniumdiolate prodrugs, diazenyl complexes etc.) have been prepared for the evaluation of their cytotoxic potential towards various cancer cell lines. Majority of them have shown promising cytotoxic activities even against several drug resistant cell lines. These derivatives have shown their effect by acting as alkylating agents, releasers of cytotoxic NO, targeting receptors like tyrosine kinase, EGFR or targeting enzymes like GST, AGT, CDKs etc. Their interaction with different receptors or enzymes leads to DNA damage, necrosis or apoptosis resulting in cell death. The present review will cover updated information on the synthetic methodologies and cytotoxic potential of diazenyl derivatives developed during the past years along with the recent developments. This may prove to be helpful for the researchers to develop novel anticancer drugs in future by molecular modifications of potential derivatives with better cytotoxic activities.


PubMed | Md University Rohtak
Type: Journal Article | Journal: Central nervous system agents in medicinal chemistry | Year: 2015

In last decade, the development of new drugs and drug products for central nervous system (CNS) has remained limited due to incomplete elucidation of pathophysiology of many CNS disorders, complexity of the diseases and the lack of technologies for delivery through the blood-brain barrier (BBB). In this article we will summarize the development of diazenyl derivatives of many biologically active moieties like benzodiazepine, formazan, indole, pyrimidine, thiazole, sulfonamide etc. as diagnostic and therapeutic agents for CNS. The potential of already existing azo compounds as potent CNS agents have also been discussed. This overview will provide the researchers an opportunity for further development of new diazenyl derivatives in CNS area.

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