Manipala, India
Manipala, India
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Ahmed A.,MCOPS | Rajendaran K.,MCOPS | Singh H.P.,JKK Nataraja Dental College and Hospital | Mishra A.,JKK Nataraja Dental College and Hospital | And 3 more authors.
International Journal of ChemTech Research | Year: 2010

Snakebite is an important cause of morbidity and mortality and is one of the major health problems in India. Russell's viper or daboia (Viper russelli) appears to be the commonest cause of fatal snakebite in Southern India, Pakistan, Bangladesh, Sri Lanka, Burma and Thailand. Intravenous administration of antibothropic antivenom neutralizes the systemic actions, but it is of little effect on the reversal of local symptoms and often induces adverse reactions, a context that drives the search for complementary treatments for snakebite accidents. Vegetable extracts with a range of antiophidian activities constitute an excellent alternative. In this study, we investigated the anti-venom effects of different extracts of Pouzolzia indica. The alcoholic and aqueous extracts of P. indica showed potent snake venom neutralizing capacity against Russell viper venom.

The present study was carried out in rats to test the efficacy of aqueous combined extract of E.jambolana and A .marmelos on serum insulin, hyperglycemia and serum lipid profile changes associated with diabetes. Eugenia jambolana and Aegle marmelos are used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of a combined aqueous extracts of E.jambolana and A.marmelos (EA) on alloxan induced diabetic rats. The diabetes induced animals were fed with plant extracts at the increasing dosage of 200mg, 300mg and 400mg of body wt. The combined plant extracts administrated animals revealed a significant (P<0.001) increment of serum insulin levels, higher reduction in hyperglycemia and hyperlipidemia when compared to the diabetic control rats (P<0.001).

Shetty R.,KMC | Vivek G.,Sahajanand Medical Technology Pvt. Ltd | Thakkar A.,MCOPS | Sunder Mishra S.,MCOPS
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: Despite the undeniable clinical efficacy of drugeluting stents with durable polymers, concerns regarding their long-term safety have been raised, especially in more complex subsets. The Manipal-S Registry was designed to evaluate the safety and effectiveness of the biodegradable polymer coated Supralimus® Sirolimus-Eluting Coronary Stent for the treatment of coronary artery disease, across a wide range of patients who are treated in real-life clinical practice. Methods: All the consecutive 116 patients who underwent singlevessel or multiple vessel percutaneous coronary interventions with the use of Supralimus® sirolimus-eluting stents between September 2009 and December 2010, were included in this study. Patients were clinically followed-up at 1, 9, 12 and 24 months post-procedure. All clinical, procedural, and follow-up information were collected and analysed. Results: In total 116 patients, 126 lesions were implanted with 144 stents which had an average stent length of 25.8±8.0 mm. The incidences of any major adverse cardiac and cerebral events at 1, 9, 12 and 24 months were 0, 5 (4.3%), 8 (6.9%), and 10 (8.6%) respectively. Conclusion: These 24-month results clearly provide evidence for safety and effectiveness of the Supralimus® Sirolimus-eluting coronary stent system with the biodegradable polymer in real-life patients, even in those with acute myocardial infarctions.

Raghuvir Pai B.,Massachusetts Institute of Technology | Ayachit A.,KMC | Abdul Khader S.M.,Massachusetts Institute of Technology | Ahmed K.A.,Technical University of Madrid | And 3 more authors.
Australasian Physical and Engineering Sciences in Medicine | Year: 2014

Gravity associated with postural changes has a strong bearing on haemodynamics of blood flow in arteries. Its effect on stenosed cases has not been widely investigated. In the present study, variation observed in blood flow during postural changes is investigated for different conditions like standing, sleeping and head-down position. A fluid structure interaction study is carried out for idealized normal and 75 % eccentric and concentric stenosed common carotid normal artery. The results clearly indicate the effects of altered gravity on flow conditions. It was found to be very significant during head-down position and demonstrated very high arterial blood pressure in stenosed common carotid when compared with normal carotid. © 2014 Australasian College of Physical Scientists and Engineers in Medicine.

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