McMaster University is a public research university located in Hamilton, Ontario, Canada. The main campus is located on 121 hectares of land in the residential neighbourhood of Westdale, adjacent to Hamilton's Royal Botanical Gardens. The university operates six academic faculties: the DeGroote School of Business, Engineering, Health science, Humanities, Social Science, and Science. It is a member of the U15, a group of research-intensive universities in Canada.The university bears the name of Honourable William McMaster, a prominent Canadian Senator and banker who bequeathed C$900,000 to the founding of the university. McMaster University was incorporated under the terms of an act of the Legislative Assembly of Ontario in 1887, merging the Toronto Baptist College with Woodstock College. It opened in Toronto in 1890. Inadequate facilities and the gift of land in Hamilton prompted the institution to relocate in 1930. McMaster was controlled by the Baptist Convention of Ontario and Quebec until it became a privately chartered, publicly funded non-denominational institution in 1957.The university is co-educational, and has over 24,500 undergraduate and nearly 4,000 post-graduate students. Alumni and former students of the university can be found all across Canada and in 140 countries around the world. Notable alumni include government officials, academics, business leaders and two Nobel laureates. The university ranked 4th among Canadian universities and 92nd in the world according to the 2013-2014 Times Higher Education World University Rankings, 4th among Canadian universities and 90th in the world according to the 2014 Academic Ranking of World Universities, and 6th among Canadian universities and 113th in the world according to the 2014 QS World University Rankings. In addition, the McMaster University Medical School was ranked 1st in Canada and 14th in the world for clinical medicine by Times Higher Education in 2013. The McMaster athletic teams are known as the Marauders, and are members of the Canadian Interuniversity Sport. Wikipedia.
McMaster University | Date: 2016-11-04
Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.
McMaster University | Date: 2015-04-07
A display illumination module for the illumination of a rear-projection screen is provided in which a first array of light sources is positioned adjacent to a first face of an optical modulating array layer for modulating the transmission of light emitted by the first array light sources. The first array light sources emit light within a defined angular range, and the optical modulating array layer is positioned relative to the first array of light sources so that light from adjacent light sources does not overlap at the optical modulating array layer. A second array of light sources is positioned adjacent to a second side of the optical modulation array layer and is arranged such that light from the second array of light sources does not pass through said optical modulation array layer and said second array of light sources does not substantially block light from the first array of light sources passing through the optical modulating array layer. One or more display modules may be incorporated into a display system that includes a rear projection screen that is spatially offset from the optical modulating array layer so that light emitted from adjacent light sources in either the first or the second array of light sources overlaps on the screen.
3M and McMaster University | Date: 2016-12-15
A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film; providing sheet metal having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. The later applied force is greater than the initially applied force.
McMaster University | Date: 2016-10-14
Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (CE-MS) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (CE) run. The method also includes application of voltage to the single capillary subsequent to sequential injection and zonal separation of polar metabolites within each sample segment by CE such that each analyte zone migrates within its characteristic electrophoretic mobility offset in time by the spacer. The incorporation of a quality control/reference sample and the use of dilution patterning with specific injection configurations also enables encoding of information temporally for enhanced data processing with quality assurance.
McMaster University | Date: 2017-02-01
Technologies are generally described for automatically optimizing an efficiency of camera placement, numbers, and resolution in multi-camera monitoring and surveillance applications. In some examples, a fraction of a total area may be monitored at a higher resolution than the rest. Employing techniques such as combinatorial state Viterbi technique or combinatorial state trellis technique, a minimum number of cameras that provide the coverage at the needed resolution may be selected. Similarly, a number of points may be covered with at least a predefined number of cameras. For example, a subject of interest may be tracked in a public area, where specific camera(s) may be used to image the subjects face at a higher resolution than the background.
Sanofi S.A. and McMaster University | Date: 2017-01-25
The present invention relates to the assessment of the risk for development of a cardiovascular disorder. It discloses the use of biochemical markers in the assessment of the risk for development of a cardiovascular disorder. It also relates to the use of the biochemical markers or marker panels for the assessment of the risk for development of a cardiovascular disorder and to kits for performing the methods of the invention.
Sanofi S.A. and McMaster University | Date: 2017-04-12
The present invention relates to methods for assessing an increased risk for mortality comprising the determination of biochemical markers. It also relates to the use of the biochemical markers or marker panels for the assessment of an increased risk for mortality and to kits for performing the methods of the invention as well as to the therapeutic use of insulin analogues for reducing morality.
McMaster University | Date: 2016-11-25
A novel method of diagnosing cystic fibrosis in a human subject is provided. The method includes the steps of: i) determining in a biological sample from the subject the level of one or more metabolic biomarkers; ii) comparing the level of the biomarker to a control level and determining the difference between the biomarker level and the control level; and iii) determining that the subject has cystic fibrosis or a related disorder when the difference in the level of the biomarker in the sample is statistically different from the control level.
McMaster University | Date: 2017-01-13
The integration of the auxiliary power module (APM) functionality into non-dissipative balancing hardware of a high voltage battery or supercapacitor pack enables a more cost-effective non-dissipative balancing system while maintaining a similar complexity in topologies. The system uses state-space equations and three control problems to balance high-voltage energy storage elements and charge low voltage energy storage elements. Two optimization based controllers are employed to optimize both balancing and charging simultaneously.
McMaster University and Yale University | Date: 2017-07-26
A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration, or the ratio of IL-6 to IL-10, in a biological sample from the mammal, either prior to cardiac surgery or within 6 hours following surgery; comparing the sample value to a corresponding reference value; and determining that the mammal is at risk of acute kidney injury following cardiac surgery if the sample value is greater than the corresponding reference value.