McGill University is a public research university in Montreal, Canada, officially founded by royal charter in 1821. The University bears the name of James McGill, a prominent Montreal merchant from Scotland and alumnus of Glasgow University, whose bequest in 1813 formed precursory McGill College.McGill's main campus is set at the foot of Mount Royal in Downtown Montreal with the second campus, situated near fields and forested lands in Sainte-Anne-de-Bellevue, 30 kilometres west of the downtown campus on the Montreal Island. All the academic units are organized into 11 main Faculties and Schools, and the institution is one of the two members of Association of American Universities located outside the United States. Valued at $33,421 per student, the University maintains one of the largest endowments among Canadian universities on a per-student basis.McGill offers degrees and diplomas in over 300 fields of study. Most students are enrolled in five larger Faculties, namely Arts, Science, Medicine, Engineering, and Management, with the highest entering grade of any Canadian university. Tuition fees vary significantly between in-province, out-of-province, and international students, and the scholarships are very generous yet highly competitive and relatively difficult to attain, compared to other Canadian universities.McGill counts among its alumni 12 Nobel laureates and 138 Rhodes Scholars, both the most in the country, as well as three astronauts, two Canadian prime ministers, 13 justices of the Canadian Supreme Court, four foreign leaders, 28 foreign ambassadors, nine Academy Award winners, three Pulitzer Prize winners, and 28 Olympic medalists. Throughout its long history, McGill alumni were also instrumental in inventing or initially organizing football, basketball, and ice hockey and founding several other universities, including the Universities of British Columbia, Victoria, and Alberta, and the Johns Hopkins School of Medicine. Wikipedia.
McGill University | Date: 2017-02-22
The present invention provides novel cancer therapeutics for treating pancreatic cancer, and novel diagnostic methods for detecting chronic pancreatitis and pancreatic cancer. The invention pertains to antagonists of dopamine receptors that inhibit the growth of pancreatic cancer cells. The invention in particular offers new therapy options based on the inhibition of the activity or expression of dopamine receptor D2 (DRD2). Diagnostic methods of the invention comprise the detection of the expression of DRD2 in pancreatic tissue. Diagnostic kits are also comprised.
Ltd Partnership and McGill University | Date: 2017-02-15
There is disclosed a method for assessing a cancer status of biological tissue having the steps of: obtaining a Raman spectrum indicating a Raman spectroscopy response of the biological tissue, the Raman spectrum captured using a fiber-optic probe of a fiber-optic Raman spectroscopy system; inputting the Raman spectrum into a boosted tree classification algorithm of a computer program, and using the boosted tree classification algorithm for comparing, in real-time, the captured Raman spectrum to reference data and assessing the cancer status of the biological tissue based on said comparison, the reference data being previously determined based on a set of reference Raman spectra indicating Raman spectroscopy responses of reference biological tissues wherein each of the reference biological tissues is associated with a known cancer status; and generating a real-time output indicating the assessed cancer status of the biological tissue.
McGill University | Date: 2017-03-08
An implant comprising a porous microstructure is disclosed which has an external surface, where at least a region of the external surface is formed of the porous microstructure. The microstructure is defined by at least one lattice of cells. Each cell has a predetermined cell topology and a plurality of edges. One or more of the edges of each cell connect to an adjacent cell along a corresponding edge thereof. Collectively, the cells have a periodic or aperiodic arrangement within the at least one lattice.
McGill University | Date: 2017-01-04
The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.
The Hospital For Sick Children and McGill University | Date: 2017-04-12
The present disclosure relates to methods of treating or preventing a biofilm-related infection and methods of preventing and treating biofilm formation on indwelling medical devices, implants, and non-medical surfaces comprising administering at least one soluble microbial protein that is encoded by an exopolysaccharide biosynthetic operon or functional gene cluster, wherein the protein comprises a glycosyl hydrolase domain. The present disclosure further provides particular soluble glycosyl hydrolases and compositions thereof.
McGill University | Date: 2016-12-05
A system and method for graph-based publication/subscription are provided. A graph comprising nodes and edges is created, each node representative of a point of interest in an information domain, each edge linking a first node and a second node and representative of a relationship between a first and a second point of interest. A request to publish content on at least one selected node and/or at least one selected edge is received. A request to subscribe to a subset of nodes and/or a subset of edges is received from a subscriber. The subscription request is correlated with the publication request to determine whether the subset of nodes comprises the selected node and whether the subset of edges comprises the selected edge. The content is notified to the subscriber if the subset of nodes comprises the selected node and the subset of edges comprises the selected edge.
McGill University | Date: 2016-12-21
A rapid method for characteterizing and identifying micsoorganisims using Focal-Plane Array (FPA)-Fourier Transform Infrared (FTIR) spectroscopy is disclosed. Multi-pixels spectral images of unknown microorganisms spectra are analyzed and compared to spectra of reference microorganisms in databases. The method allows rapid and highly reliable identification of unknown microorganisms for the purpose of medical diagnosis, food and environmental control.
McGill University | Date: 2017-07-26
Bioluminescence resonance energy transfer (BRET) biosensors for assessing the intracellular localization, internalization and trafficking into cellular compartments of proteins such as receptors, and other biomolecules such as second messengers, are disclosed. These biosensors, which are dependent on the concentration/density of the BRET donor and acceptor in cellular compartments rather that specific protein-protein interactions, use a Renilla GFP/Luc BRET pair, which allows the robust and reproducible monitoring of protein trafficking/localization, with a sensitivity compatible with high-throughput screening (HTS). The use of these biosensors for various applications, including assessing/monitoring protein endocytosis, recycling and intracellular trafficking, receptor maturation/rescue by pharmacological chaperones, various endocytosis/exocytosis processes, activation/inhibition, as well as biomolecule concentration/density in different cellular compartments, is also disclosed.
McGill University and École de Technologie Supérieure of Montreal | Date: 2017-02-03
There is described a multi-mode unrolled decoder. The decoder comprises a master code input configured to receive a polar encoded master code of length N carrying k information bits and Nk frozen bits, decoding resources comprising processing elements and memory elements connected in an unrolled architecture and defining an operation path between the master code input and an output, for decoding a polar encoded code word, at least one constituent code input configured to receive a polar encoded constituent code of length N/p carrying j information bits and N/pj frozen bits, where p is a power of 2, and at least one input multiplexer provided in the operation path to selectively transmit N/p bits of one of the master code and the constituent code to a subset of the decoding resources.
McGill University | Date: 2017-07-19
A method of increasing drought resistance of a plant, the method comprising applying a Bacillus methylotrophicus or a composition thereof (i) to the plant or to a part of the plant; and/or (ii) to an area around the plant or plant part, in an amount effective to produce an increased drought resistance in the plant as compared to the drought stress resistance of the plant in the absence of said application of Bacillus methylotrophicus or composition, is described. A biologically pure culture of a 1-aminocyclopropane-l-carboxylate (ACC) deaminase deficient Bacillus methylotrophicus bacterium strain, or a mutant thereof able to induce drought resistance in a plant are also described.