Mazandaran University of Medical Sciences
Mazandaran, Iran

Mazandaran University of Medical science is a medical university in Sari, Mazandaran province, Iran. This university is one of the top medical universities in Iran.This university includes 9 faculties and some research centers.Sari School of MedicineStudents Researches Center of MazUMSBioinformatics and Biomathematics Unit in MazUMSMazandaranSary or Sari, IranCaspian SeaSari Academic HospitalAvicenna HospitalMazandaran Cardiovascular Diseases CenterPsychiatric Hospital of Sari Wikipedia.

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Akbari M.,Mazandaran University of Medical Sciences
Journal of Hypertension | Year: 2017

BACKGROUND:: High blood pressure in children is a public health problem and the most important risk factor for cardiovascular disease at an older age. Several preliminary studies have been published regarding the prevalence of high blood pressure in which there was significant disparity. OBJECTIVE:: This study aimed to estimate the prevalence of hypertension in Iranian children using the meta-analysis approach. METHODS:: A systematic search of national and international databases was conducted through September 30, 2015, for population studies providing estimates on the prevalence of hypertension in Iranian children and adolescents. From the extracted prevalence rates, the heterogenic index of the studies was determined using Cochranʼs (Q) and Chi-squared (I2) tests, and on the basis of the heterogenetic results, a fixed or random effects model was employed to estimate the pooled prevalence rate of hypertension. Meta-regression was performed to determine those factors suspected of generating heterogeneity. RESULTS:: Of 2360 articles initially identified, 17 were considered eligible. The meta-analyses included 79?231 children and adolescents aged between 3 and 18 years. The pooled prevalence of hypertension among children and adolescents was estimated to be 8.9% [95% confidence interval (95% CI): 7.5–10.3] in overall, 10.3% (95% CI: 7.5–12.6) in males and 9.1% (95% CI: 7.4–10.7) in females. The prevalence rates of high DBP and SBP were estimated at 6.6% (95% CI: 3.9–9.2) and 6.9% (95% CI: 5.6–8.2), respectively. CONCLUSION:: There is a high prevalence of hypertension among Iranian children and adolescents. Although it is slightly higher among boys than girls, the difference was not statistically significant. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Hosseinimehr S.J.,Mazandaran University of Medical Sciences | Hosseinimehr S.J.,Uppsala University
Drug Discovery Today | Year: 2010

DNA is the cellular target that has the most damage induced by ionizing radiation (IR). If genomic instability resulting from this DNA damage is not correctly repaired, it leads to mutation, cancer and cell death. Flavonoids are a family of natural products that affect oxidative stress and enhance genomic stability through DNA interaction. Although flavonoids exert protective effects against IR in normal cells, they enhance genotoxicity effects of this radiation in cancer cells, a beneficial effect that is of interest in the design of new anticancer pharmaceuticals. This review describes the molecular effects of IR on DNA structure and mechanisms by which flavonoids exert their effect on ionizing-radiation-induced genomic instability. © 2010 Elsevier Ltd.

Salehifar E.,Mazandaran University of Medical Sciences | Hosseinimehr S.J.,Mazandaran University of Medical Sciences
Drug Discovery Today | Year: 2016

Cyclooxygenase-2 (COX-2) is overexpressed in cancer cells and is associated with carcinogenesis and maintenance of progressive tumour growth as well as resistance of cancer cells to ionising radiation (IR). COX-2 inhibitors can attenuate tumour growth and expression of markers of cell proliferation as well as induce apoptosis in tumour cells. These agents can have a synergistic effect with IR in the killing of cancer cells. In this review, we discuss the rational basis and molecular mechanisms regarding the usefulness of COX-2 inhibitors in cancer therapy, and also their potential role in increasing the therapeutic index of chemoradiation by protecting normal cells and sensitising tumour cells to radiotherapy. © 2016 Elsevier Ltd. All rights reserved.

Enayati A.,Mazandaran University of Medical Sciences
Annual Review of Entomology | Year: 2010

The prospect of malaria eradication has been raised recently by the Bill and Melinda Gates Foundation with support from the international community. There are significant lessons to be learned from the major successes and failures of the eradication campaign of the 1960s, but cessation of transmission in the malaria heartlands of Africa will depend on a vaccine and better drugs and insecticides. Insect control is an essential part of reducing transmission. To date, two operational scale interventions, indoor residual spraying and deployment of long-lasting insecticide-treated nets (LLINs), are effective at reducing transmission. Our ability to monitor and evaluate these interventions needs to be improved so that scarce resources can be sensibly deployed, and new interventions that reduce transmission in a cost-effective and efficient manner need to be developed. New interventions could include using transgenic mosquitoes, larviciding in urban areas, or utilizing cost-effective consumer products. Alongside this innovative development agenda, the potential negative impact of insecticide resistance, particularly on LLINs, for which only pyrethroids are available, needs to be monitored. © 2010 by Annual Reviews All rights reserved.

Gharaei-Fathabad E.,Mazandaran University of Medical Sciences
American Journal of Drug Discovery and Development | Year: 2011

Biosurfactants can be served as green alternatives in a variety of applications including bioremediation, pharmaceuticals, agricultural disease control and cosmetics. Biosurfactant mixtures produced by microbes and they are genus- and sometimes species-specific. Because of their short fatty acid tails and polar head groups, biosurfactants are highly sticky and both hydrophilic and hydrophobic. In pharmaceutics, biosurfactants can be used for gene delivery and recovery of intracellular products as well as they can be served as antimicrobial substances and emulsifying agents. © 2011 Academic Journals Inc.

Ahmadi A.,Mazandaran University of Medical Sciences
Chinese Journal of Integrative Medicine | Year: 2012

In recent years, more head and neck cancer patients have been treated with radiotherapy. Radiation-induced mucositis is a common and dose limiting toxicity of radiotherapy among patients with head and neck cancers. Patients undergoing radiation therapy for head and neck cancer are also at increased risk of developing oral candidiasis. A number of new agents applied locally or systemically to prevent or treat radiationinduced mucositis have been investigated, but there is no widely accepted prophylactic or effective treatment for mucositis. Topical Aloe vera is widely used for mild sunburn, frostbites, and scalding burns. Studies have reported the beneficial effects of Aloe gel for wound healing, mucous membrane protection, and treatment of oral ulcers, in addition to antiinflammatory, immunomudulation, antifungal, scavenging free radicals, increasing collagen formation and inhibiting collagenase. Herein the author postulates that oral Aloe vera mouthwash may not only prevent radiation-induced mucositis by its wound healing and antiinflammatory mechanism, but also may reduce oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties. Hence, Aloe vera mouthwash may provide an alternative agent for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers. © 2012 The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg.

Khalatbary A.R.,Mazandaran University of Medical Sciences
Nutritional Neuroscience | Year: 2013

Olive oil is a rich source of phenolic components which have a wide variety of beneficial health effects in vitro, in vivo, and clinically. The beneficial effects of olive oil phenols attributed to a variety of biological activities including free radical scavenging/antioxidant actions, anti-inflammatory effects, anti-carcinogenic properties, and anti-microbial activities. On the other hand, olive oil phenols have been shown to be some of neuroprotective effects against cerebral ischemia, spinal cord injury, Huntington's disease, Alzheimer's diseases, multiple sclerosis, Parkinson's disease, aging, and peripheral neuropathy. This paper summarizes current knowledge on the mechanisms of neuroprotective effects of olive oil phenols. © W. S. Maney & Son Ltd 2013.

Honary S.,Mazandaran University of Medical Sciences | Zahir F.,Mazandaran University of Medical Sciences
Tropical Journal of Pharmaceutical Research | Year: 2013

The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorption into body membranes are dramatically altered by ZP. In this paper the effect of ZP on the various properties of nano-medicines are reviewed. Furthermore, the ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.

Honary S.,Mazandaran University of Medical Sciences | Zahir F.,Mazandaran University of Medical Sciences
Tropical Journal of Pharmaceutical Research | Year: 2013

Zeta potential is a scientific term for electrokinetic potential in colloidal systems which has a major effect on the various properties of nano-drug delivery systems. Presently, colloidal nano-carriers are growing at a remarkable rate owing to their strong potential for overcoming old challenges such as poor drug solubility and bioavailability. Furthermore, they show an unlimited capacity in the field of drug targeting. The properties of nano-medicines such as release from dosage forms at specific sites as well as drug circulation and absorption into body membranes are dramatically affected by some physical and chemical characteristics of nano-drugs. Particle size and charge are two major factors which could play key roles in this regard. In this paper, the effect of zeta potential on different properties of nano-drug delivery systems is reviewed. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.

Hosseinimehr S.J.,Mazandaran University of Medical Sciences
Future Oncology | Year: 2014

Angiotensin II receptor antagonists inhibit various signaling pathways involved in the regulation of inflammation, apoptosis and angiogenesis. Radiation-induced activation of a proinflammatory cytokine network has been shown to mediate normal tissue injury induced by ionizing radiation in cancer patients, resulting in serious side effects. Hence, not only do angiotensin II receptor antagonists block inflammatory signaling both in cancer cells and in normal cells, but they are also effective in the treatment of cancer by inhibiting tumor progression, vascularization and metastasis. This review addresses the role of angiotensin II inhibitors in cancer therapy, and their potential to increase therapeutical index by protecting normal cells and sensitizing tumor cells to radiotherapy. © 2014 Future Medicine Ltd.

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