Mazandaran, Iran

Mazandaran University of Medical science is a medical university in Sari, Mazandaran province, Iran. This university is one of the top medical universities in Iran.This university includes 9 faculties and some research centers.Sari School of MedicineStudents Researches Center of MazUMSBioinformatics and Biomathematics Unit in MazUMSMazandaranSary or Sari, IranCaspian SeaSari Academic HospitalAvicenna HospitalMazandaran Cardiovascular Diseases CenterPsychiatric Hospital of Sari Wikipedia.


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Akbari M.,Mazandaran University of Medical Sciences
Journal of Hypertension | Year: 2017

BACKGROUND:: High blood pressure in children is a public health problem and the most important risk factor for cardiovascular disease at an older age. Several preliminary studies have been published regarding the prevalence of high blood pressure in which there was significant disparity. OBJECTIVE:: This study aimed to estimate the prevalence of hypertension in Iranian children using the meta-analysis approach. METHODS:: A systematic search of national and international databases was conducted through September 30, 2015, for population studies providing estimates on the prevalence of hypertension in Iranian children and adolescents. From the extracted prevalence rates, the heterogenic index of the studies was determined using Cochranʼs (Q) and Chi-squared (I2) tests, and on the basis of the heterogenetic results, a fixed or random effects model was employed to estimate the pooled prevalence rate of hypertension. Meta-regression was performed to determine those factors suspected of generating heterogeneity. RESULTS:: Of 2360 articles initially identified, 17 were considered eligible. The meta-analyses included 79?231 children and adolescents aged between 3 and 18 years. The pooled prevalence of hypertension among children and adolescents was estimated to be 8.9% [95% confidence interval (95% CI): 7.5–10.3] in overall, 10.3% (95% CI: 7.5–12.6) in males and 9.1% (95% CI: 7.4–10.7) in females. The prevalence rates of high DBP and SBP were estimated at 6.6% (95% CI: 3.9–9.2) and 6.9% (95% CI: 5.6–8.2), respectively. CONCLUSION:: There is a high prevalence of hypertension among Iranian children and adolescents. Although it is slightly higher among boys than girls, the difference was not statistically significant. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.


Enayati A.,Mazandaran University of Medical Sciences
Annual Review of Entomology | Year: 2010

The prospect of malaria eradication has been raised recently by the Bill and Melinda Gates Foundation with support from the international community. There are significant lessons to be learned from the major successes and failures of the eradication campaign of the 1960s, but cessation of transmission in the malaria heartlands of Africa will depend on a vaccine and better drugs and insecticides. Insect control is an essential part of reducing transmission. To date, two operational scale interventions, indoor residual spraying and deployment of long-lasting insecticide-treated nets (LLINs), are effective at reducing transmission. Our ability to monitor and evaluate these interventions needs to be improved so that scarce resources can be sensibly deployed, and new interventions that reduce transmission in a cost-effective and efficient manner need to be developed. New interventions could include using transgenic mosquitoes, larviciding in urban areas, or utilizing cost-effective consumer products. Alongside this innovative development agenda, the potential negative impact of insecticide resistance, particularly on LLINs, for which only pyrethroids are available, needs to be monitored. © 2010 by Annual Reviews All rights reserved.


Gharaei-Fathabad E.,Mazandaran University of Medical Sciences
American Journal of Drug Discovery and Development | Year: 2011

Biosurfactants can be served as green alternatives in a variety of applications including bioremediation, pharmaceuticals, agricultural disease control and cosmetics. Biosurfactant mixtures produced by microbes and they are genus- and sometimes species-specific. Because of their short fatty acid tails and polar head groups, biosurfactants are highly sticky and both hydrophilic and hydrophobic. In pharmaceutics, biosurfactants can be used for gene delivery and recovery of intracellular products as well as they can be served as antimicrobial substances and emulsifying agents. © 2011 Academic Journals Inc.


Ahmadi A.,Mazandaran University of Medical Sciences
Chinese Journal of Integrative Medicine | Year: 2012

In recent years, more head and neck cancer patients have been treated with radiotherapy. Radiation-induced mucositis is a common and dose limiting toxicity of radiotherapy among patients with head and neck cancers. Patients undergoing radiation therapy for head and neck cancer are also at increased risk of developing oral candidiasis. A number of new agents applied locally or systemically to prevent or treat radiationinduced mucositis have been investigated, but there is no widely accepted prophylactic or effective treatment for mucositis. Topical Aloe vera is widely used for mild sunburn, frostbites, and scalding burns. Studies have reported the beneficial effects of Aloe gel for wound healing, mucous membrane protection, and treatment of oral ulcers, in addition to antiinflammatory, immunomudulation, antifungal, scavenging free radicals, increasing collagen formation and inhibiting collagenase. Herein the author postulates that oral Aloe vera mouthwash may not only prevent radiation-induced mucositis by its wound healing and antiinflammatory mechanism, but also may reduce oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties. Hence, Aloe vera mouthwash may provide an alternative agent for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers. © 2012 The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg.


Khalatbary A.R.,Mazandaran University of Medical Sciences
Nutritional Neuroscience | Year: 2013

Olive oil is a rich source of phenolic components which have a wide variety of beneficial health effects in vitro, in vivo, and clinically. The beneficial effects of olive oil phenols attributed to a variety of biological activities including free radical scavenging/antioxidant actions, anti-inflammatory effects, anti-carcinogenic properties, and anti-microbial activities. On the other hand, olive oil phenols have been shown to be some of neuroprotective effects against cerebral ischemia, spinal cord injury, Huntington's disease, Alzheimer's diseases, multiple sclerosis, Parkinson's disease, aging, and peripheral neuropathy. This paper summarizes current knowledge on the mechanisms of neuroprotective effects of olive oil phenols. © W. S. Maney & Son Ltd 2013.


Honary S.,Mazandaran University of Medical Sciences | Zahir F.,Mazandaran University of Medical Sciences
Tropical Journal of Pharmaceutical Research | Year: 2013

The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorption into body membranes are dramatically altered by ZP. In this paper the effect of ZP on the various properties of nano-medicines are reviewed. Furthermore, the ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.


Honary S.,Mazandaran University of Medical Sciences | Zahir F.,Mazandaran University of Medical Sciences
Tropical Journal of Pharmaceutical Research | Year: 2013

Zeta potential is a scientific term for electrokinetic potential in colloidal systems which has a major effect on the various properties of nano-drug delivery systems. Presently, colloidal nano-carriers are growing at a remarkable rate owing to their strong potential for overcoming old challenges such as poor drug solubility and bioavailability. Furthermore, they show an unlimited capacity in the field of drug targeting. The properties of nano-medicines such as release from dosage forms at specific sites as well as drug circulation and absorption into body membranes are dramatically affected by some physical and chemical characteristics of nano-drugs. Particle size and charge are two major factors which could play key roles in this regard. In this paper, the effect of zeta potential on different properties of nano-drug delivery systems is reviewed. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.


Tilaki R.A.D.,Mazandaran University of Medical Sciences
Journal of Industrial Microbiology and Biotechnology | Year: 2011

By adding a biomass carrier to an activated sludge system, the biomass concentration will increase, and subsequently the organic removal efficiency will be enhanced. In this study, the possibility of using excess sludge from ceramic and tile manufacturing plants as a biomass carrier was investigated. The aim of this study was to determine the effect of using fireclay as a biomass carrier on biomass concentration, organic removal and nitrification efficiency in an activated sludge system. Experiments were conducted by using a bench scale activated sludge system operating in batch and continuous modes. Artificial simulated wastewater was made by using recirculated water in a ceramic manufactutring plant. In the continuous mode, hydraulic detention time in the aeration reactor was 8 and 22 h. In the batch mode, aeration time was 8 and 16 h. Fireclay doses were 500, 1,400 and 2,250 mg l-1, and were added to the reactors in each experiment separately. The reactor with added fireclay was called a Hybrid Biological Reactor (HBR). A reactor without added fireclay was used as a control. Efficiency parameters such as COD, MLVSS and nitrate were measured in the control and HBR reactors according to standard methods. The average concentration of biomass in the HBR reactor was greater than in the control reactor. The total biomass concentration in the HBR reactor (2.25 g l-1 fireclay) in the continuous mode was 3,000 mg l-1 and in the batch mode was 2,400 mg l-1. The attached biomass concentration in the HBR reactor (2.25 g l-1 fireclay) in the continuous mode was 1,500 mg l-1 and in the batch mode was 980 mg l-1. Efficiency for COD removal in the HBR and control reactor was 95 and 55%, respectively. In the HBR reactor, nitrification was enhanced, and the concentration of nitrate was increased by 80%. By increasing the fireclay dose, total and attached biomass was increased. By adding fireclay as a biomass carrier, the efficiency of an activated sludge system to treat wastewater from ceramic manufacturing plants was increased. © 2010 Society for Industrial Microbiology.


Makhlough A.,Mazandaran University of Medical Sciences
Iranian Journal of Kidney Diseases | Year: 2010

Introduction. Pruritus is one of the common problems in patients on hemodialysis. There are several causes for pruritus, and different treatment modalities are applied to control it. The aim of this study was to evaluate the therapeutic effect of capsaicin on pruritus, compared with placebo, in patients on hemodialysis, Materials and Methods. This randomized double-blinded crossover clinical trial was performed on 34 patients on hemodialysis with uremic pruritus. The patients were divided into 2 groups, one group received capsaicin 0.03% and the other, placebo, for 4 weeks. Treatment was stopped for 2 weeks as washout period and continued as a cross-over technique. Pruritus scores were analyzed and compared, Results. Thirty-four patients on long-term hemodialysis, 14 men and 20 women with a mean age of 57.0 ± 18.6 years were studied. The mean of pruritus score before capsaicin treatment was 15.9 ± 6.3, which was reduced to 6.4 ± 3.9, 4.7 ± 3.1, 3.2 ± 2.9, and 2.5 ± 2.5 on weeks 1 to 4, respectively (P <.001). In the placebo group, pruritus score before treatment was 15.0 ± 6.0 on average, and it was 11.7 ± 5.8, 9.4 ± 5.9, 7.9 ± 5.5, and 7.2 ± 5.5, respectively, on weeks 1 to 4 (P <.001). There was no significant difference in pruritus scores before the treatment between the two groups, but after each week, the difference was significant (P <.001). Repeated measurement test showed that decreasing in pruritus severity in the capsaicin group was more than that in the placebo group during treatment period (P <.001), Conclusions. Capsaicin is a new safe and effective topical treatment for hemodialysis-induced pruritus in patients with end-stage renal disease.


Hosseinimehr S.J.,Mazandaran University of Medical Sciences
Future Oncology | Year: 2014

Angiotensin II receptor antagonists inhibit various signaling pathways involved in the regulation of inflammation, apoptosis and angiogenesis. Radiation-induced activation of a proinflammatory cytokine network has been shown to mediate normal tissue injury induced by ionizing radiation in cancer patients, resulting in serious side effects. Hence, not only do angiotensin II receptor antagonists block inflammatory signaling both in cancer cells and in normal cells, but they are also effective in the treatment of cancer by inhibiting tumor progression, vascularization and metastasis. This review addresses the role of angiotensin II inhibitors in cancer therapy, and their potential to increase therapeutical index by protecting normal cells and sensitizing tumor cells to radiotherapy. © 2014 Future Medicine Ltd.

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