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Kosiorek H.E.,Mayo ClinicScottsdale Arizona | Senyak Z.,MPN Research FoundationChicago Illinois | Dueck A.C.,Mayo ClinicScottsdale Arizona | Boxer M.A.,Arizona OncologyTucson Arizona | And 6 more authors.
Cancer | Year: 2015

BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) experience a high persistence, prevalence, and severity of fatigue. There is currently only limited information regarding factors that contribute to fatigue in patients with MPNs. METHODS: A 70-item, Internet-based survey regarding fatigue was developed by MPN investigators and patients/advocates and hosted by the Mayo Clinic Survey Research Center. RESULTS: Fatigue was found to be prevalent and severe among international survey respondents (1788 respondents). Higher body mass index (P<.001), current use of alcohol (P<.001), and current tobacco use (P=.0025) were found to be significantly associated with greater fatigue. Moderate/severe fatigue was present more frequently in those individuals who did not exercise compared with those who reported exercising at least once per week (P<.001). Medical comorbidities found to be significantly associated with greater fatigue included restless leg syndrome (P=.006), diabetes mellitus (P=.045), fibromyalgia (P<0.001), chronic fatigue syndrome (P=.006), and chronic kidney disease (P=.02). Current use of antidepressants (P<.001), antihistamines (P=.0276), antianxiety medications (P=.0357), and prescription pain medications (P<.001) were found to be associated with worsened fatigue. Nearly 25% of respondents scored>2 on the Patient Health Questionnaire, indicating a high probability of depression. Higher Brief Fatigue Inventory score, Myeloproliferative Neoplasm Total Symptom Score, and individual symptom items were all associated with a higher likelihood of depressive symptoms (P<.0001). CONCLUSIONS: The management of fatigue should be multifactorial, with a comprehensive assessment and treatment plan to address all modifiable fatigue etiologies. Patients with MPNs likely have a higher prevalence of mood disturbances compared with the general population, suggesting the need to assess and intervene in this domain. © 2015 American Cancer Society.

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