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Scottsdale, AZ, United States

Lacy B.E.,Dartmouth Hitchcock Medical Center | Levenick J.M.,Dartmouth Hitchcock Medical Center | Crowell M.D.,Mayo Clinic in Scottsdale
Gastroenterology and Hepatology | Year: 2012

Chronic constipation and irritable bowel syndrome (IBS) are functional gastrointestinal disorders that significantly affect patients' quality of life. Chronic constipation and IBS are prevalent-12% of the US population meet the diagnostic criteria for IBS, and 15% meet the criteria for chronic constipation- and these conditions negatively impact the healthcare system from an economic perspective. Despite attempts at dietary modification, exercise, or use of over-the-counter medications, many patients have persistent symptoms. Alternative treatment options are limited. This article describes linaclotide (Linzess, Ironwood Pharmaceuticals/Forest Pharmaceuticals), a new, firstin- class medication for the treatment of chronic constipation and constipation-predominant IBS. Source


Kawashima A.,Mayo Clinic in Scottsdale | Young S.W.,Mayo Clinic in Scottsdale | Takahashi N.,Mayo Medical School | King B.F.,Mayo Medical School | Atwell T.D.,Mayo Medical School
Abdominal Radiology | Year: 2016

Hereditary forms of kidney carcinoma account for 5–8% of all malignant kidney neoplasms. The renal tumors are often multiple and bilateral and occur at an earlier age. Each of the hereditary kidney carcinoma syndromes is associated with specific gene mutations as well as a specific histologic type of kidney carcinoma. The presence of associated extrarenal manifestations may suggest a hereditary kidney cancer syndrome. Radiology is most commonly used to screen and manage patients with hereditary kidney cancer syndromes. This manuscript reviews the clinical and imaging findings of well-defined inherited kidney cancer syndromes including von Hippel–Lindau disease, Birt–Hogg–Dubé syndrome, hereditary papillary renal carcinoma syndrome, hereditary leiomyomatosis and RCC syndrome, tuberous sclerosis complex, and Lynch syndrome. © 2016, Springer Science+Business Media New York. Source

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