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Rochester, MN, United States

Nakamura I.,Mayo Clinic and Mayo Clinic Cancer Center | Fernandez-Barrena M.G.,Mayo Clinic and Mayo Clinic Cancer Center | Ortiz-Ruiz M.C.,University of Murcia | Almada L.L.,Schulze Center for Novel Therapeutics | And 17 more authors.
Journal of Biological Chemistry

Background: Tissue regeneration is a complex process involving a network of ligand-activated pathways. Results: The sulfatase SULF2 modulates cell proliferation and organ growth through a WNT-dependent activation of the transcription factor GLI1. Conclusion: Together, these data define a novel cascade regulating tissue regeneration. Significance: The knowledge derived from this study will contribute to the understanding of the molecular mechanisms modulating regeneration and organogenesis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Source

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