Nakamura I.,Mayo Clinic and Mayo Clinic Cancer Center |
Fernandez-Barrena M.G.,Mayo Clinic and Mayo Clinic Cancer Center |
Ortiz-Ruiz M.C.,University of Murcia |
Almada L.L.,Schulze Center for Novel Therapeutics |
And 17 more authors.
Journal of Biological Chemistry
Background: Tissue regeneration is a complex process involving a network of ligand-activated pathways. Results: The sulfatase SULF2 modulates cell proliferation and organ growth through a WNT-dependent activation of the transcription factor GLI1. Conclusion: Together, these data define a novel cascade regulating tissue regeneration. Significance: The knowledge derived from this study will contribute to the understanding of the molecular mechanisms modulating regeneration and organogenesis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Source