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Chen T.-S.,National Chung Hsing University | Chen Y.-T.,National Chung Hsing University | Liu C.-H.,Maxluck Biotechnology Corporation | Sun C.-C.,Maxluck Biotechnology Corporation | Mao F.C.,National Chung Hsing University
Biological Trace Element Research | Year: 2015

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder and one of the most common causes of anovulatory infertility. In addition, insulin resistance is commonly associated with PCOS and contributed to pathophysiology connected to dietary minerals including chromium (Cr), copper (Cu), iron (Fe), and zinc (Zn). The aims of this study were to explore whether PCOS in mice alters levels of these elements and determine if Cr supplementation resolves changes. Twenty-four female BALB/c mice were divided into three groups of eight mice [normal control (NC), PCOS + placebo milk (PP), and PCOS + Cr-containing milk (PCr)]. Each group received a high-fat diet for 4 weeks. Our results show significantly higher levels of dehydroepiandrosterone (DHEA) (p < 0.001), fasting glucose (p < 0.05), and fasting insulin (p < 0.05) in the PP group compared with both NC and PCr group. However, Cr levels were significantly lower in muscle, bone, and serum in the PP group (p < 0.05) compared with NC and PCr groups. In liver, bone, and serum, Fe levels were significantly higher in the PP group compared with the NC group (p < 0.05). In addition, we found significant correlations between Cu/Zn ratio and fasting insulin in all mice (r = 0.61; p = 0.002). Given that significant research shows that Cr supplementation improves fasting glucose, fasting insulin, and metal metabolism disorders for PCOS mice, our data suggest that trace element levels can serve as biomarkers to prescribe therapeutic supplementation to maintain a healthy metabolic balance and treat disease conditions. © 2015, Springer Science+Business Media New York.

Chen W.-Y.,National Chung Hsing University | Chen W.-Y.,Maxluck Biotechnology Corporation | Chen C.-J.,Taichung Veterans General Hospital | Liu C.-H.,National Chung Hsing University | And 2 more authors.
Biochemical and Biophysical Research Communications | Year: 2010

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with insulin resistance, oxidative stress, and inflammation. Evidence indicates that chromium has a role in the regulation of glucose and lipid metabolism and may improve insulin sensitivity. In this study, we report that chromium supplementation has a beneficial effect against NAFLD. We found that KK/HlJ mice developed obesity and progressed to NAFLD after feeding with high-fat diet for 8. weeks. High-fat-fed KK/HlJ mice showed hepatocyte injury and hepatic triglyceride accumulation, which was accompanied by insulin resistance, oxidative stress, and inflammation. Chromium supplementation prevented progression of NAFLD and the beneficial effects were accompanied by reduction of hepatic triglyceride accumulation, elevation of hepatic lipid catabolic enzyme, improvement of glucose and lipid metabolism, suppression of inflammation as well as resolution of oxidative stress, probably through enhancement of insulin signaling. Our findings suggest that chromium could serve as a hepatoprotective agent against NAFLD. © 2010 Elsevier Inc.

Maxluck Biotechnology Corporation | Date: 2009-04-28

Dietary food supplements, food supplements, mineral food supplements; nutritional additives for medical purposes for use in foods and dietary supplements for human consumption.

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