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Rostock, Germany

Schneider D.,HELIOS Hospital Schwerin Oral and Maxillofacial Surgery | Radloff S.,Maxillo facial Surgery | Bolz M.,University of Rostock | Briese V.,University of Rostock
Zeitschrift fur Geburtshilfe und Neonatologie | Year: 2014

Background: This communication presents precise percentile values for birth weight, birth length and cranial circumference of infants in Mecklenburg-Pomerania, Germany. Material and Methods: Based on data from the German Perinatal Survey of the years 1994-2011 in Mecklenburg-Pomerania, the 3rd, 10th, 25th, 50th, 75 th, 90th and 97th percentile values for birth weight, birth length and head circumference are specified. The measurements of a total of 174084 infants from non-multiple births are shown. Results: The statistically calculated percentile values are presented in tabular and graph forms. The mean birth weight of the infants was 3437.8g. The average age of the mothers was 27.9 years. The average duration of pregnancy was 39.4 complete weeks. Conclusions: The insights gained from many years of data collection are presented as standardised, regional percentile values and curves for Mecklenburg-Pomerania for the first time. The differentiated presentation for the federal state opens the possibility for individually tailored consultations in clinical practice and may provide support for recognised national curves for these values.©Georg Thieme Verlag KG Stuttgart. New York. Source

Gasparini G.,Columbus University | Saponaro G.,Columbus University | Marianetti T.M.,Columbus University | Tamburrini G.,Policlinico Universitario melli | And 3 more authors.
Child's Nervous System | Year: 2013

Purpose: Maxillary and mandibular alterations in children affected by anterior synostotic plagiocephaly have, until today, received only scarce attention. The goal of this paper is to focus on the mandibular alterations, persisting after the early correction of anterior plagiocephaly during the first year of life. Methods: Maxillary and mandibular metric measurements were performed on high resolution, thin slices CT scans; all images were reconstructed into 3D models which were used to perform the metrical assessments. Results: Twelve patients were selected; all of them had been treated in early age with a neurosurgical intervention and had reached the end of maxillo-mandibular growth at the time of the evaluation. Significant discrepancies were documented between the two affected sides, with all measured distances being shorter on the synostotic side than the nonsynostotic one, the only exception being the vertical dimension of the mandibular ramus. Discussion: Mandibular alterations resulted to be characterized by lower jaw hypoplasia on the side of the affected suture and anterior displacement of the glenoid fossa; these two entities compensated each other uncompletely, ending in a rotation of the mandibula towards the synostotic side. © 2012 Springer-Verlag Berlin Heidelberg. Source

Cerda T.,Radiation Oncology | Sun X.S.,Radiation Oncology | Vignot S.,Medical Oncology | Marcy P.-Y.,Center Antoine Lacassagne | And 7 more authors.
Critical Reviews in Oncology/Hematology | Year: 2014

Background: Salivary gland carcinomas constitute a heterogeneous group of tumors, with over 20 histological subtypes of various prognoses. The mainstay of treatment is surgery, with radiotherapy advocated for unresectable disease or postoperatively in case of poor prognostic factors such as high grade, locally advanced and/or incompletely resected tumors. Concurrent chemotherapy is sometimes advocated in routine practice based on criteria extrapolated from squamous cell carcinomas of the head and neck, on radioresistance of salivary gland tumors and on results obtained in the metastatic setting. The aim of this review was to identify situations where chemotherapy is advocated. Material and methods: A search of literature was performed with the following key words: parotid, salivary gland, neoplasm, cancer, malignant tumor, chemoradiation, chemotherapy, radiotherapy and treatment. Case report and studies published before 2000 were not included. Results: Platinum-based regimens were the most frequent. Other regimens were reported and seemed dependent on histology. The level of evidence for the concurrent delivery of chemotherapy with radiation therapy is supported by a low level of evidence. Prescribing chemotherapy mostly relies on poor prognostic factors similar to those used to indicate high dose radiotherapy. Protocols vary with histology. Conclusion: The rationale for adding chemotherapy to radiotherapy remains to be demonstrated prospectively. Although the type of systemic treatments used may be adapted on histology, the strongest rationale remains in favor of cisplatin. © 2014 Elsevier Ireland Ltd. Source

Vescovi P.,University of Parma | Campisi G.,University of Palermo | Fusco V.,Hospital of Alessandria | Mergoni G.,University of Parma | And 8 more authors.
Oral Oncology | Year: 2011

Invasive local procedures are often reported in clinical history of patients suffering from Bisphosphonates-Related Osteonecrosis of the Jaws (BRONJ) but over 40% of spontaneous forms have been also described in literature. We compared age, gender, underlying bone disorders, bisphosphonate therapy, clinical features and surgical outcome of 205 cases (36.2%) of BRONJ non surgery-triggered (group 1) with 362 (63.8%) cases of surgery-triggered forms (group 2). Differences between group 1 and 2 were analysed using Mann-Whitney U and χ2 tests. Statistical analysis was performed using STATA 8. Zoledronate was the most used type of bisphosphonate (63.4% versus 69.0%) and the mandible was the most frequently involved site (63.9% versus 63.4%) in both groups. BRONJ in group 1 was more frequently multicentric (9.3% versus 5%, p < 0.05), had a lower clinical stage (45.9% versus 13.8% in stage 1, p < 0.01) and had a better outcome after surgical therapy (improvement in 74.1% versus 58.6%, p < 0.05). The high prevalence of non surgery-triggered forms of BRONJ should be considered by oncologists, haematologists and general physicians who are advised to inform their patients regarding the importance of preventive dental protocols to control the possible causes of osteonecrosis not related to dental invasive procedures. © 2010 Elsevier Ltd. All rights reserved. Source

Martinelli M.,University of Bologna | Carinci F.,University of Ferrara | Morselli P.G.,University of Bologna | Palmieri A.,University of Ferrara | And 4 more authors.
International Journal of Immunopathology and Pharmacology | Year: 2011

The 12q13 region has been suggested as a candidate locus for orofacial cleft by different investigators. In the present study we tested the region for linkage with non syndromic cleft lip with or without cleft palate in a collection of 39 Italian multigenerational families, using microsatellite markers. No evidence of linkage was detected between the marker map and NSCLP under different mode of inheritance nor with a nonparametric method. Formal level of linkage exclusion, were obtained for each point of the map. Genetic heterogeneity and the different impact of the candidate locus among populations could explain conflicting results obtained in different studies. © SAGE Publications. Source

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