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Deussen O.,University of Konstanz | Bulthoff H.,Max Planck Institute For Biologische Kybernetik | Ertl T.,University of Stuttgart | Keim D.,University of Konstanz | And 3 more authors.
Informatik-Spektrum | Year: 2010

Developments in display technology produced a variety of high resolution displays in last years. In the joint research group "Information at your finger tips - interactive visualization for gigapixel displays" we investigated a number of challenges for computer science that are caused by this technology ranging from system design up to interaction methods, display algorithms and applications in visualization and art. © 2010 Springer-Verlag. Source


Kirschfeld K.,Max Planck Institute For Biologische Kybernetik | Land M.F.,University of Sussex
Ophthalmologe | Year: 2011

Bifocal or multifocal intraocular lenses (IOLs) can be used to replace natural lenses during cataract surgery. These lenses are recommended by cataract surgeons as the replacement lenses of choice when patients wish to avoid wearing spectacles. There are, however, drawbacks to these lenses: one drawback is that the contrast in the images of bifocal and multifocal lenses is reduced as documented in the ophthalmology literature. It is claimed that acuity is similar in multifocal compared to monofocal lenses, however, we show that any loss in contrast inevitably reduces visual acuity. The other drawback is that the sharp in-focus image is always seen superimposed on one or more blurred out of focus images of the same object. In the ophthalmology literature it is assumed that the brain can suppress the undesired blurred image and only perceive the sharp image. We argue that there are no known mechanisms that would make this possible. This means that vision with bifocal or multifocal implanted lenses cannot be as good as vision with monofocal implants supplemented by spectacles, and this should be explained to patients before undergoing surgery for lens replacement. The results also hold for bifocal and multifocal contact lenses. © 2011 Springer-Verlag. Source


Oberhettinger P.,Institute For Medizinische Mikrobiologie Und Hygiene | Schutz M.,Institute For Medizinische Mikrobiologie Und Hygiene | Raddatz G.,Max Planck Institute For Biologische Kybernetik | Keller H.,Max Planck Institute For Entwicklungsbiologie | And 2 more authors.
Plasmid | Year: 2011

Our laboratory strain Yersinia enterocolitica strain WA-314 biogroup 1B serotype O:8 displayed a different adhesion behavior to host cells compared to other Yersinia strains. To investigate whether this is based on differences in the gene content of the large pYV virulence plasmid which contains the major Yersinia adhesin YadA, we set out to sequence pYV WA-314. pYV WA-314 is very similar to pYV127/90, with a notable difference in the length of the Type III secretion system component YscP, which determines the needle length of the system. We found that we could improve the annotation of proteins previously described as "hypothetical" in pYV127/90 and other pYV plasmids, and show that pYV plasmids contain several and seemingly redundant plasmid partitioning and stabilization systems, explaining why these plasmids are not easily lost in laboratory cultures of Yersinia strains. © 2010 Elsevier Inc. Source


Kim K.I.,Max Planck Institute For Biologische Kybernetik | Kwon Y.,KAIST
IEEE Transactions on Pattern Analysis and Machine Intelligence | Year: 2010

This paper proposes a framework for single-image super-resolution. The underlying idea is to learn a map from input low-resolution images to target high-resolution images based on example pairs of input and output images. Kernel ridge regression (KRR) is adopted for this purpose. To reduce the time complexity of training and testing for KRR, a sparse solution is found by combining the ideas of kernel matching pursuit and gradient descent. As a regularized solution, KRR leads to a better generalization than simply storing the examples as has been done in existing example-based algorithms and results in much less noisy images. However, this may introduce blurring and ringing artifacts around major edges as sharp changes are penalized severely. A prior model of a generic image class which takes into account the discontinuity property of images is adopted to resolve this problem. Comparison with existing algorithms shows the effectiveness of the proposed method. © 2010 IEEE. Source


The etiology of retinal detachment in central serous retinopathy (CSR) is unknown; however, three facts are generally accepted: (1) the serous exudate which raises the layers of the receptors/pigment epithelium is formed due to hyperpermeability in the choriocapillaries, (2) patients frequently suffer from headaches and (3) stress promotes the incidence of CSR. A high blood plasma histamine concentration can cause the abovementioned symptoms which suggests that histamine might provoke CSR. Within 1 week after administration of the antihistamine loratadin a considerable reduction in the retinal exudate and restoration of vision were observed. This supports the hypothesis that histamine could be involved in the process of retinal detachment. Further investigations and large scale clinical trials should clarify if this hypothesis can be proved or disproved and whether antihistamines can be used for age-related macular degeneration (AMD). © 2014, ©The Author (2014) This article is published with open access at Springerlink.com. Source

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