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Robinson D.E.,Mawson InstituteUniversity of South AustraliaMawson LakesAdelaide | Al-Bataineh S.A.,Mawson InstituteUniversity of South AustraliaMawson LakesAdelaide | Farrugia B.L.,The New School | Michelmore A.,Mawson InstituteUniversity of South AustraliaMawson LakesAdelaide | And 5 more authors.
Plasma Processes and Polymers | Year: 2016

Plasma polymerization was used to coat a melt electrospun polycaprolactone scaffold to improve cell attachment and organization. Plasma polymerization was performed using an amine containing monomer, allylamine, which then allowed for the subsequent immobilization of biomolecules, i.e., heparin and fibroblast growth factor-2. The stability of the plasma-polymerized amine-coating was demonstrated by X-ray photoelectron spectroscopy analysis and imaging time-of-flight secondary ion mass spectrometry revealed that a uniform plasma amine-coating was deposited throughout the scaffold. Based upon comparison with controls, it was evident that the combination scaffold aided cell ingress and the formation of distinct fibroblast and keratinocyte layers. Adsorption of appropriate biomolecules is crucial for the development of high quality tissue-engineered constructs. Here plasma polymerization is used to modify the surface of a 3D melt electrospun polycaprolactone scaffold such that heparin and therefore growth factors can be immobilized. This surface modification resulted in the production of a synthetic human skin equivalent with distinct epidermal and dermal layers. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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