Mawson Institute

Mawson Lakes, Australia

Mawson Institute

Mawson Lakes, Australia
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Chong H.T.,University of Adelaide | Kopecki Z.,Mawson Institute | Cowin A.J.,Mawson Institute
BioMed Research International | Year: 2013

Psoriasis is a common chronic inflammatory skin condition in which patients suffer from mild to chronic plaque skin plaques. The disease manifests through an excessive inflammatory response in the skin due to complex interactions between different genetic and environmental factors. Psoriasis can affect the physical, emotional, and psychosocial well-being of patients, and currently there is no cure with treatments focusing primarily on the use of anti-inflammatory agents to control disease symptoms. Traditional anti-inflammatory agents can cause immunosuppression and adverse systemic effects. Further understanding of the disease has led to current areas of research aiming at the development of selective molecular targets to suppress the pathogenic immune responses. © 2013 Heng T. Chong et al.


Ramiasa M.N.,Mawson Institute | Cavallaro A.A.,Mawson Institute | Mierczynska A.,CNR Institute of Neuroscience | Gleadle J.M.,Flinders University | Vasilev K.,Mawson Institute
Chemical Communications | Year: 2015

Poly(2-oxazoline)s are emerging revolutionary biomaterials, exhibiting comparable and even superior properties to well-established counterparts. Overcoming current tedious wet synthesis methods, we report solvent-free and substrate independent, plasma polymerised nanoscale biocompatible polyoxazoline coatings capable of controlling protein and cell adhesion, and significantly reducing biofilm build up. © 2015 The Royal Society of Chemistry.


Pi K.,Hubei Engineering University | Pi K.,Mawson Institute | Pi K.,Key Laboratory of Ecological Remediation for Lakes and Rivers and Algal Utilization of Hubei Province | Xia M.,Hubei Engineering University | And 8 more authors.
Journal of Water Process Engineering | Year: 2015

Ca(OH)2/MgSO4·7H2O/Al2(SO4)3·18H2O coagulant was employed to pretreat tobacco wastewater (TW). The experimental conditions of initial pH, reaction time and coagulant dosage were optimized by the response surface methodology (RSM) using chemical oxygen demand (COD) decrease. The optimum conditions achieved through Box-Behnken design were pH 8.2, reaction time 11.3min and a coagulant dosage of 47.8gL-1 with a molar ratio for Ca:Mg:Al of 4:1:2. Under these conditions, the maximum COD decrease was 62% and the color decreased to 10 times. The coagulant had no significant effect on nicotine removal from the wastewater, with more than 92% remaining after treatment. IR spectroscopy of the flocculated slurry showed that the coagulant mainly removed organics including protein, carbohydrate, cellulose, hemicelluloses, pigment and nitrogen compounds from the TW. © 2014 Elsevier Ltd.


Bachhuka A.,Mawson Institute | Hayball J.,University of South Australia | Smith L.E.,Mawson Institute | Smith L.E.,University of South Australia | And 2 more authors.
ACS Applied Materials and Interfaces | Year: 2015

Surface modification has been identified as an important technique that could improve the response of the body to implanted medical devices. Collagen production by fibroblasts is known to play a vital role in wound healing and device fibrous encapsulation. However, how surface chemistry affects collagen I and III deposition by these cells has not been systematically studied. Here, we report how surface chemistry influences the deposition of collagen I and III by primary human dermal fibroblasts. Amine (NH3), carboxyl acid (COOH), and hydrocarbon (CH3) surfaces were generated by plasma deposition. This is a practically relevant tool to deposit a functional coating on any type of substrate material. We show that fibroblasts adhere better and proliferate faster on amine-rich surfaces. In addition, the initial collagen I and III production is greater on this type of coating. These data indicates that surface modification can be a promising route for modulating the rate and level of fibrous encapsulation and may be useful in informing the design of implantable biomedical devices to produce more predictable clinical outcomes. © 2015 American Chemical Society.


Li J.,Mawson Institute | Addai-Mensah J.,University of South Australia | Thilagam A.,Mawson Institute | Gerson A.R.,Mawson Institute
Crystal Growth and Design | Year: 2012

We present experimental and molecular modeling studies, which examine the influence of crystal growth modifiers (CGMs) on the crystallization mechanism and kinetics of gibbsite crystallization in supersaturated sodium aluminate solutions. Seeded, pure caustic sodium aluminate synthetic liquors and real industrial Bayer liquor containing significant amounts of organic and inorganic impurities, in the absence and presence of a CGM containing oleate ions, were investigated. Our results show massive growth of colloidal sized protrusions on the seed particle surfaces on addition of the CGM in the pure synthetic caustic aluminate liquors. Although the activation energies for both secondary nucleation and growth were found to be increased, the overall crystallization rate was surprisingly also increased by addition of CGM. This behavior is attributed to the increased pre-exponential factor possibly arising from higher probability of effective collisions due to more effective species orientation facilitating the crystallization process. The crystallization rate was significantly slower in the industrial Bayer liquor, most likely due to the presence of impurities; nevertheless, a greater degree of surface protrusions on crystal growth was noted on addition of the CGM. In conjunction with the experimental results, we use semiempirical quantum-chemical calculations to examine the underlying processes that result in the enhanced growth due to the presence of the CGM. Our quantum-chemical modeling results suggest that the increased crystallization rate may be due to a mechanism by which Al(III)-containing dimers are produced due to intervention by the oleate ion. © 2012 American Chemical Society.


Chandrasekaran S.,Mawson Institute | Macdonald T.J.,Ian Wark Research Institute | Gerson A.R.,Mawson Institute | Gerson A.R.,University of South Australia | And 2 more authors.
ACS Applied Materials and Interfaces | Year: 2015

An effective solar-powered silicon device for hydrogen production from water splitting is a priority in light of diminishing fossil fuel vectors. There is increasing demand for nanostructuring in silicon to improve its antireflective properties for efficient solar energy conversion. Diatom frustules are naturally occurring biosilica nanostructures formed by biomineralizing microalgae. Here, we demonstrate magnesiothermic conversion of boron-doped silica diatom frustules from Aulacoseira sp. into nanostructured silicon with retention of the original shape. Hydrogen production was achieved for boron-doped silicon diatom frustules coated with indium phosphide nanocrystal layers and an iron sulfur carbonyl electrocatalyst. © 2015 American Chemical Society.


PubMed | Mawson Institute
Type: Journal Article | Journal: Chemical communications (Cambridge, England) | Year: 2015

Poly(2-oxazoline)s are emerging revolutionary biomaterials, exhibiting comparable and even superior properties to well-established counterparts. Overcoming current tedious wet synthesis methods, we report solvent-free and substrate independent, plasma polymerised nanoscale biocompatible polyoxazoline coatings capable of controlling protein and cell adhesion, and significantly reducing biofilm build up.

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