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Sant'Ambrogio di Torino, Italy

Dato G.M.A.,Mauriziano Umberto I Hospital of Turin | Sansone F.,Mauriziano Umberto I Hospital of Turin | Omede P.,San Giovanni Battista Hospital | Zingarelli E.,Mauriziano Umberto I Hospital of Turin | And 8 more authors.
International Journal of Artificial Organs | Year: 2012

Introduction: Coronary artery disease (CAD), along with its main complications such as acute myocardial infarction (AMI) and congestive heart failure (CHF), remains a serious worldwide problem and affects many patients despite the improvement of Medical treatment. The possibility of the replacement of the infarcted areas by the re-generation of the myocardial cells has been long discussed and the mobilization of the stem cells from bone marrow (BMCs) to the peripheral blood (PB) induced by cytokines, represents a potential pathway to activate the regenerative process. Patients and Methods: We describe BMC mobilization and direct/indirect revascularization in 15 patients operated on for coronary artery bypass grafting (CABG) and/or mitral valve surgery and/or ventricular remodeling combined to multiple trans-myocardial punctures (Sen technique) in ungraftable non-viable fibrotic areas. Results: Peak values of circulating BMCs were recorded between day +4 and day +6. We had no inhospital (0-30 days) mortality. All the patients were discharged from the ICU after a Median period of 2 days while the in-hospital length of stay was 10.5±4.2 days (range 7-21) and all patients were discharged in good clinical condition. There were two sudden deaths over the mid-term, at postoperative day (POD) 32 and 45 respectively. Conclusions: Our study suggests that the combination of BMC mobilization and CABG may be safely performed. However, considering the small series, final conclusions about the benefit of this procedure must await a larger prospective study comparing the role of cytokines alone, myocardial perforation, and the combination of both. © 2012 Wichtig Editore. Source

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