Bunkyo-ku, Japan
Bunkyo-ku, Japan

Matsuyama University is a private university in Matsuyama, Ehime, Japan. The predecessor of the school was founded in 1923, and it was chartered as a university in 1949. The present name was adopted in 1989. Shiho Ochi and Kōichi Tabo of Superfly are alumni. Wikipedia.

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Ohura K.,Kumamoto University | Tasaka K.,Kumamoto University | Hashimoto M.,Matsuyama University | Imai T.,Kumamoto University
Drug Metabolism and Disposition | Year: 2014

The age-associated alteration in expression levels of carboxylesterases (CESs) can affect both intestinal and hepatic first-pass metabolism after oral administration of xenobiotic esters such as prodrugs. In this study, the age-related expression of CES isozymes and hydrolase activities were simultaneously investigated in liver, jejunum, and ileum from 8-, 46-, and 90-week-old rats. Rat liver expresses three major CES1 isozymes, Hydrolase A, Hydrolase B, and Hydrolase C, as well as one minor CES1 (Egasyn) and three minor CES2 isozymes (RL4, AY034877, and D50580). The mRNA and protein levels of major hepatic CES1 isozymes were decreased in an age-dependent manner, while those of minor CESs were maintained in all age groups. The hepatic hydrolase activity for temocapril was decreased in an age-dependent manner, accompanied by downregulation of Hydrolase B/C mRNA, while age-independent hydrolysis of propranolol derivatives was observed in rat liver, due to the contribution of Egasyn. Rat small intestine expresses one major CES2 (RL4) and four minor CESs (Hydrolase B, Hydrolase C, Egasyn, and AY034877). Interestingly, the expression of RL4 was age-dependently increased in both jejunum and ileum, while minor isozymes showed a constant expression across a wide age range. The up-regulation of RL4 expression with aging led to an increase of intestinal hydrolase activities for temocapril and propranolol derivatives. Consequently, age-dependent changes in the expression of CES isozymes affect the hydrolysis of xenobiotics in both rat liver and small intestine. Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics.

Tanabe T.,Matsuyama University
Yakugaku Zasshi | Year: 2016

The genus Vibrio includes >70 species, of which roughly a dozen cause vibriosis such as gastroenteritis, wound infections, and septicemia. Most bacteria, including Vibrio species, require iron for survival and growth. However, the bioavailability of iron is extremely low because it is usually present as an insoluble ferric complex in an aerobic environment or is bound to iron-binding proteins in mammalian hosts. Therefore many bacteria have developed iron acquisition systems, including biosynthesis and secretion of low-molecular-mass iron-chelating compounds called siderophores, and uptake of iron-bound siderophores into bacterial cells through specific active transport systems. Vibrio parahaemolyticus, a major pathogenic Vibrio species, contains multiple iron-acquisition systems mediated by its own siderophore vibrioferrin and several xenosiderophores produced by other microorganisms. In this review, I have focused on the transcriptional and posttranscriptional regulation of genes encoding iron acquisition systems in V. parahaemolyticus. All genes involved in its iron acquisition systems are repressed by Fur, which acts as a ferrous-dependent transcriptional repressor. Furthermore, the stability of polycistronic mRNA involved in vibrioferrin biosynthesis is positively regulated by a small RNA, RyhB, which is repressed by Fur. Expression of PeuA receptor required for utilization of a xenosiderophore, enterobactin, occurs under iron-limiting conditions at alkaline pH. PeuA expression is induced by a two-component regulatory system, PeuRS, which enhances expression of an alternative peuA transcript without an intrinsic translation-inhibitory structure in response to changes in alkaline pH. © 2016 The Pharmaceutical Society of Japan.

Amakura Y.,Matsuyama University
Yakugaku Zasshi | Year: 2017

Ephedra Herb (Japanese name: mao) is defined as the terrestrial stem of Ephedra species. It is one of the most im­portant crude drugs in Kampo prescriptions such as maoto, kakkonto, and shoseiryuto. The traditional biological properties of Ephedra Herb are mainly attributable to ephedrine alkaloids. Recently, our research group has found that Ephedra Herb extract also shows alkaloid-independent pharmacological action; therefore, we focused on polyphenols, other active ingredients of Ephedra Herb extract. Reports on the constituents of the extract other than ephedrine alkaloids are limited, although condensed tannins of procyanidin A-type have been found in some Ephedra species. To determine the components associated with the antitumor activity of Ephedra Herb extract, we investigated the phenolic compounds in the extract and characterized 10 compounds, including the new compound herbacetin 7-O-neohesperido- side, together with catechins and flavonoids with an apigenin or a herbacetin skeleton, and phenylpropanoids such as syringin. Of the 10 compounds, isovitexin 2ʺ-O-rhamnoside was obtained in the greatest yield. Here, we describe the elucidation of part of the polyphenolic fraction from Ephedra Herb extract. © 2017 The Pharmaceutical Society of Japan.

Koshima H.,Matsuyama University | Takechi K.,Matsuyama University | Uchimoto H.,Matsuyama University | Shiro M.,Rigaku Corporation | Hashizume D.,RIKEN
Chemical Communications | Year: 2011

Platelike microcrystals of N-3,5-di-tert-butylsalicylidene-3-nitroaniline repeatedly bend and straighten upon alternate irradiation with UV and visible light. The mechanism of bending was elucidated by X-ray crystallographic analyses before and after photoirradiation. © 2011 The Royal Society of Chemistry.

Dan Y.,Matsuyama University
Proceedings - 11th IEEE/IPSJ International Symposium on Applications and the Internet, SAINT 2011 | Year: 2011

It is essential to consider the structure of information media in order to investigate the phenomena of information diffusion. As an example of continuous media, we consider on Euclidean spaces in the ordinary geometry. We also know information networks which have a variety of metric and structure in the space as another example of discrete media. In this work, we are faced the limit of mathematical analysis of nonlinear structure of information networks, then perform the Monte Carlo computer simulation using the proposed method. © 2011 IEEE.

Uesugi S.,Matsuyama University
Proceedings - 2011 International Conference on Advances in Social Networks Analysis and Mining, ASONAM 2011 | Year: 2011

A number of social networking services (SNSs) have become increasingly popular in recent years, as characterized by the growing number of their users and the deepening penetration of their services. As the number of users increases, the variety of user profiles, serving as a reflection of the real world, also increases. Psychological aspects must be taken into account to better understand the behaviors of SNS users. This study investigated the relationships between personality traits and SNS usage, and the results of a preliminary survey using the Big Five model of personality traits are reported herein. © 2011 IEEE.

Saijo R.,Matsuyama University | Kawase M.,Matsuyama University
Tetrahedron Letters | Year: 2012

In this report, we describe a new method for the synthesis of densely functionalized pyrroles. Reaction of mesoionic 1,3-oxazolium-5-olates with various S-ylides proceeds via nucleophilic addition followed by opening of the oxazole ring and subsequent cyclization to multisubstituted pyrroles bearing both a trifluoromethyl and alkyl(aryl)thio group at 3- and 4-positions. © 2012 Elsevier Ltd. All rights reserved.

Carley H.,Matsuyama University
Communications in Computer and Information Science | Year: 2015

This paper discusses Internet Communication Technology (ICT) and in particular social networking in relationship to usage by senior citizens. Social networking as a percentage has been steadily increasing among all age groups including seniors. While the elderly may develop varying physical discrepancies such as auditory and optic complications these should not hinder their abilities to utilize social media devices. Not only does social networking allow for spontaneous intercommunication but for the elderly it can benefit overall wellbeing of the participants. Additionally, physical dexterity may be improved through continued use. It has been readily accepted that lifelong learning can lead to a decrease in mental decrepitude. The overall health benefits go beyond just communicating with grandchildren. Educational institutions and marketing establishments have yet to fully capitalize on the potential of senior social networking. © Springer-Verlag Berlin Heidelberg 2015.

Yoshimura M.,Matsuyama University
Yakugaku Zasshi | Year: 2014

Tannins and related polyphenols have been reported to produce diverse biological effects that indicate their therapeutic potential, including antioxidative, antibacterial, and antiviral activities. In an exploratory study of natural antioxidants with biological effects, we investigated the tannin constituents of myrtaceous plants reported to be rich in polyphenols. We isolated 16 new compounds from five species of the Melaleuca, Eucalyptus, Syzygium, Pimenta,and Myrtus genera. Among the new polyphenols, nine were isolated from Melaleuca squarrosa and characterized as C-gluco-sidic ellagitannin monomers and oligomers. The structures of the other new polyphenols from myrtaceous plants and a novel compound obtained from the berries of Pyracantha coccinea (Rosaceae) were also elucidated based on spectroscopic and chemical evidence. The antioxidative activity of isolates in the present study was estimated by measuring 1,1-diphenyl-2-picrylhydrazyl radical (DPPH)-scavenging activity and in the oxygen radical absorbance capacity (ORAC) test. We found that oenothein B, a macrocyclic ellagitannin dimer, is widely distributed in the genus Eucalyptus and produces a significant immunomodulatory effect on human dendritic cells (DCs). In a survey of natural ligands that bind to the aryl hydrocarbon receptor (AhR), nepitrin, a flavonoid glycoside, and other polyphenols were revealed to be promising therapeutic candidates. © 2014 The Pharmaceutical Society of Japan.

Saijo R.,Matsuyama University | Hagimoto Y.,Matsuyama University | Kawase M.,Matsuyama University
Organic Letters | Year: 2010

Mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1), obtained from the reaction of N-acyl-N-alkylglycines with trifluoroacetic anhydride, react with phosphorus ylides to give β-trifluoromethylpyrroles (2) in good yields. The novel ring transformations of 1 into 2 occur via an initial attack of the ylide anions on the C-2 position of the ring. © 2010 American Chemical Society.

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