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Matsumoto, Japan

Hirao M.,Osaka University | Hirai Y.,Matsumoto Hospital | Ebina K.,Osaka University | Shi K.,Osaka University | And 4 more authors.
Modern Rheumatology | Year: 2016

Hallux valgus (HV) deformity is associated with hindfoot valgus deformity. We experienced a case that suggests the possibility that valgus correction for varus hindfoot with bony ankylosis of the subtalar joint by total ankle arthroplasty may have caused a forefoot HV deformity, despite adequate valgus correction. © 2016 Japan College of Rheumatology Source


Fukui H.,Matsumoto Hospital | Kou C.,Matsumoto Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2012

The prognosis for pancreatic cancer with distant metastasis is not good. The case reported here concerns a pancreatic body cancer with multiple liver metastases for which multidisciplinary therapy of S-1+gemcitabine (GEM) therapy, surgery, and radiofrequency ablation proved to be effective, resulting in complete remission. The patient was a 77-year-old female. She was asymptomatic and diagnosed with pancreatic body cancer with multiple liver metastasis at the end of December 2008 by ultrasonography. After careful examination, GEM 1, 200 mg/body was administered on days 1 and 15, and S-1 was administered orally at 80 mg/day for two weeks, followed by two weeks of rest. By the end of the 15th course, the size of the tumor had reduced from 26.5 mm to 14.4 mm, and all but one of the liver lesions disappeared; the remaining one lesion was measured as 14.5 mm by ultrasonography. We performed pancreas body and tail resection and radiofrequency therapy for the remaining single liver metastasis. After operation, GEM was administered once a month for 4 months. S-1 was not administered, but a new lesion was revealed at the S8 area by ultrasonography. We restarted S-1+GEM therapy and in 5 months the new lesion disappeared from image examinations. She is alive and in complete remission 16 months after the operation. Source


Kobayashi M.,Matsumoto Hospital | Furuta K.,Matsumoto Hospital | Kitamura H.,Matsumoto Medical Center | Oguchi K.,center | And 3 more authors.
Clinical Journal of Gastroenterology | Year: 2011

Primary biliary cirrhosis (PBC) is frequently complicated with hepatocellular carcinoma (HCC), but complication with combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) or cholangiocellular carcinoma (CCC) has not been reported. Here, we describe a case of PBC in which cHCC-CC occurred. The patient was a 70-year-old man who had developed jaundice at 62 years old. He was diagnosed with PBC based on a liver biopsy and blood tests. In August 2006, blood tests showed elevated alpha-fetoprotein, and a liver tumor in the right lobe and a metastatic lymphadenopathy in the back near to the head of the pancreas were detected by abdominal contrast-enhanced CT. A 18F-fluorodeoxyglucose-PET scan showed accumulation of the tracer in the tumor and in a lymph node at the back of the pancreas. The tumor and lymph node were removed, and the tumor was diagnosed pathologically as cHCC-CC based on the presence of features of HCC and CCC. This case is the first to show that a patient with PBC can develop cHCC-CC. This is of interest, since cHCC-CC may originate in hepatic stem cells or hepatic precursor cells. This case also suggests that cHCCCC should be included as a differential diagnosis for a liver tumor complicated with PBC. © Springer 2011. Source


Joshita S.,Iida Municipal Hospital | Shirahata K.,Iida Municipal Hospital | Yazaki Y.,Matsumoto Medical Center | Okaniwa S.,Iida Municipal Hospital | And 13 more authors.
Hepatology Research | Year: 2013

A 61-year-old Japanese woman suffered from a small, painful, subcutaneous nodule on the sole of her foot that was 10mm across in diameter during pegylated interferon (PEG IFN) and ribavirin (RBV) combination therapy for chronic hepatitis C. Skin biopsy revealed multiple non-caseating granulomas composed of epithelioid histiocytes with multinucleate giant cells, which was consistent with sarcoidosis. Ophthalmologic examination revealed uveitis. Thoracic computed tomography (CT) showed multiple bilateral hilar lymphadenopathies and a diffuse micronodular interstitial pattern of the lungs. Genetic analysis indicated a probable homozygous haplotype of A*02:01-C*15:02-B*51:01-DRB1*16:02-DQB1*05:02 in human leukocyte antigen regions. The patient was observed carefully without any additional medication because no significant systemic symptoms were noted. Combination therapy was continued for 2months afterwards. She was asymptomatic for over 3years of follow up, and repeated hematological and biological investigations and chest CT showed improvement. In conclusion, clinicians should bear sarcoidosis in mind as a complication during PEG IFN and RBV combination therapy. They should also be aware of the usually good prognosis of PEG IFN-induced cutaneous sarcoidosis in order not to prematurely discontinue a treatment necessary for liver disease; maintenance of PEG IFN treatment may be advised with careful follow up. © 2013 The Japan Society of Hepatology. Source


Fukui H.,Matsumoto Hospital | Kou C.,Matsumoto Hospital | Matsumoto T.,Matsumoto Hospital | Matsumoto M.,Matsumoto Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2010

Objective: The prognosis for pancreatic cancer with distant metastases is not good. The case reported here is of pancreatic body cancer with multiple liver metastasis in which S-1+gemcitabine (GEM) therapy proved to be effective. Case: A 77-year-old female. She was asymptomatic and diagnosed as a pancreatic body cancer with multiple liver metastases at the end of December 2008 by periodical ultrasonography. After careful examination, GEM 1,200 mg/body was administered on days 1 and 15, and S-1 was administered orally at 80 mg/day for two weeks, followed by two weeks rest. Currently, at the end of the 10th course, tumor size has been reduced from 26.5 mm to 18.9 mm, and two of the five liver metastatic lesions have disappeared, while the remaining three liver lesions have been revealed as scars by CT examination. Tumor marker levels have been remarkably decreased. Ten months from the initial diagnosis, there has been no side effect and chemotherapy is being continued. Conclusion: In pancreatic cancer with distant metastases, S-1+GEM therapy may be able to provide a long-term prognosis. Source

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